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• W2898905963 endingPage "367" @default.
• W2898905963 startingPage "356" @default.
• W2898905963 abstract "Formation of new bone by osteoblasts is mediated via the activation of signaling pathways, such as TGF-&#946;, BMP, and Wnt. A number of transcription factors participate in the signaling cascades that are tightly regulated by other regulatory factors. Histone deacetylases (HDACs) are one such class of regulatory factors that play an essential role in influencing chromatin architecture and regulate the expression of the genes that play a role in osteoblast differentiation by the mechanism of deacetylation. Four classes of HDACs have been identified namely, class I, class II A, class II B, class III and class IV. MicroRNAs (miRNAs) are small fragments of non-coding RNAs typically 19-25 nucleotides long that target mRNAs to upregulate or downregulate gene expression at a post-transcriptional level. A number of miRNAs that target HDACs in bone have been recently reported. Hence, in this review, we elaborate on the various miRNAs that target the different classes of HDACs and impact of the same on osteogenesis." @default.
• W2898905963 created "2018-11-09" @default.
• W2898905963 creator A5010593788 @default.
• W2898905963 creator A5039586692 @default.
• W2898905963 creator A5073093541 @default.
• W2898905963 creator A5090347084 @default.
• W2898905963 date "2019-02-15" @default.
• W2898905963 modified "2023-09-27" @default.
• W2898905963 title "Regulation of Histone Deacetylases by MicroRNAs in Bone" @default.
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