FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898924061> ?p ?o ?g. }

• W2898924061 endingPage "1252" @default.
• W2898924061 startingPage "1243" @default.
• W2898924061 abstract "Exposure to airborne fine particulate matter (PM2.5) has been associated with a variety of adverse health outcomes including chronic obstructive pulmonary disease (COPD). However, the linkages between PM2.5 exposure, PM2.5-related biomarkers, COPD-related biomarkers and COPD remain poorly elucidated. To investigate the linkages between PM2.5 exposure and COPD outcome by using the meet-in-middle strategy based on urinary metabolic biomarkers. A cross-sectional study was designed to illustrate the mentioned quadripartite linkages. Indoor PM2.5 and its element components were assessed in 41 Chinese elderly participants including COPD patients and their healthy spouses. Metabolic biomarkers involved in PM2.5 exposure and COPD were identified by using urinary metabolomics. The associations between PM2.5- and COPD-related biomarkers were investigated by statistics and metabolic pathway analysis. Seven metabolites were screened and identified with significant correlations to PM2.5 exposure, which were majorly involved in purine and amino acid metabolism as well as glycolysis. Ten COPD-related metabolic biomarkers were identified, which suggested that amino acid metabolism, lipid and fatty acid metabolism, and glucose metabolism were disturbed in the patients. Also, PM2.5 and its many elemental components were significantly associated with COPD-related biomarkers. We observed that the two kinds of biomarkers (PM2.5- and COPD-related) integrated in a locally connected network and the alterations of these metabolic biomarkers can biologically link PM2.5 exposure to COPD outcome. Our study indicated the modification of PM2.5 to COPD via both modes of action of lowering participants' antioxidation capacity and decreasing their lung energy generation; this information would be valuable for the prevention strategy of COPD." @default.
• W2898924061 created "2018-11-09" @default.
• W2898924061 creator A5023739349 @default.
• W2898924061 creator A5028400991 @default.
• W2898924061 creator A5028702225 @default.
• W2898924061 creator A5031767346 @default.
• W2898924061 creator A5034060293 @default.
• W2898924061 creator A5036933417 @default.
• W2898924061 creator A5068452513 @default.
• W2898924061 creator A5077544471 @default.
• W2898924061 creator A5079058063 @default.
• W2898924061 creator A5085323287 @default.
• W2898924061 creator A5086618239 @default.
• W2898924061 date "2018-12-01" @default.
• W2898924061 modified "2023-10-18" @default.
• W2898924061 title "The modification of indoor PM2.5 exposure to chronic obstructive pulmonary disease in Chinese elderly people: A meet-in-metabolite analysis" @default.
• W2898924061 cites W1906179062 @default.
• W2898924061 cites W1973777808 @default.
• W2898924061 cites W1982498199 @default.
• W2898924061 cites W2049149517 @default.
• W2898924061 cites W2059898775 @default.
• W2898924061 cites W2060728683 @default.
• W2898924061 cites W2081087203 @default.
• W2898924061 cites W2098418396 @default.
• W2898924061 cites W2115206345 @default.
• W2898924061 cites W2117241990 @default.
• W2898924061 cites W2124805213 @default.
• W2898924061 cites W2134160513 @default.
• W2898924061 cites W2136871188 @default.
• W2898924061 cites W2139808649 @default.
• W2898924061 cites W2142370584 @default.
• W2898924061 cites W2155868617 @default.
• W2898924061 cites W2156405617 @default.
• W2898924061 cites W2157410405 @default.
• W2898924061 cites W2162550564 @default.
• W2898924061 cites W2164706046 @default.
• W2898924061 cites W2316954565 @default.
• W2898924061 cites W2345561471 @default.
• W2898924061 cites W2409023605 @default.
• W2898924061 cites W2545658160 @default.
• W2898924061 cites W2593219292 @default.
• W2898924061 cites W2593996367 @default.
• W2898924061 cites W2616930788 @default.
• W2898924061 cites W2624303488 @default.
• W2898924061 cites W2624588518 @default.
• W2898924061 cites W2628498187 @default.
• W2898924061 cites W2693852273 @default.
• W2898924061 cites W2724713175 @default.
• W2898924061 cites W2741412919 @default.
• W2898924061 cites W2746051823 @default.
• W2898924061 cites W2780804271 @default.
• W2898924061 cites W2781505895 @default.
• W2898924061 cites W2783527425 @default.
• W2898924061 cites W2792257827 @default.
• W2898924061 cites W2793404076 @default.
• W2898924061 cites W2793813530 @default.
• W2898924061 cites W2795444285 @default.
• W2898924061 cites W2800088760 @default.
• W2898924061 cites W2807591745 @default.
• W2898924061 doi "https://doi.org/10.1016/j.envint.2018.10.046" @default.
• W2898924061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30389378" @default.
• W2898924061 hasPublicationYear "2018" @default.
• W2898924061 type Work @default.
• W2898924061 sameAs 2898924061 @default.
• W2898924061 citedByCount "51" @default.
• W2898924061 countsByYear W28989240612019 @default.
• W2898924061 countsByYear W28989240612020 @default.
• W2898924061 countsByYear W28989240612021 @default.
• W2898924061 countsByYear W28989240612022 @default.
• W2898924061 countsByYear W28989240612023 @default.
• W2898924061 crossrefType "journal-article" @default.
• W2898924061 hasAuthorship W2898924061A5023739349 @default.
• W2898924061 hasAuthorship W2898924061A5028400991 @default.
• W2898924061 hasAuthorship W2898924061A5028702225 @default.
• W2898924061 hasAuthorship W2898924061A5031767346 @default.
• W2898924061 hasAuthorship W2898924061A5034060293 @default.
• W2898924061 hasAuthorship W2898924061A5036933417 @default.
• W2898924061 hasAuthorship W2898924061A5068452513 @default.
• W2898924061 hasAuthorship W2898924061A5077544471 @default.
• W2898924061 hasAuthorship W2898924061A5079058063 @default.
• W2898924061 hasAuthorship W2898924061A5085323287 @default.
• W2898924061 hasAuthorship W2898924061A5086618239 @default.
• W2898924061 hasBestOaLocation W28989240611 @default.
• W2898924061 hasConcept C126322002 @default.
• W2898924061 hasConcept C135870905 @default.
• W2898924061 hasConcept C185592680 @default.
• W2898924061 hasConcept C192989942 @default.
• W2898924061 hasConcept C21565614 @default.
• W2898924061 hasConcept C2776780178 @default.
• W2898924061 hasConcept C2777477808 @default.
• W2898924061 hasConcept C2780026642 @default.
• W2898924061 hasConcept C2781197716 @default.
• W2898924061 hasConcept C2910206359 @default.
• W2898924061 hasConcept C2992779976 @default.
• W2898924061 hasConcept C42407357 @default.
• W2898924061 hasConcept C55493867 @default.
• W2898924061 hasConcept C60644358 @default.
• W2898924061 hasConcept C62231903 @default.

• next