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• W2898946950 abstract "Background: In search of novel anticancer agents, a series of 1,3,4-oxadiazole derivatives (12a-j) containing 1,3,4-thiadiazole moieties were synthesized, and their structures were confirmed by 1HNMR, 13CNMR and ESI-MS spectral analysis. Methods: Cytotoxicity of these compounds was evaluated by MTT assay in vitro against four human tumor cell lines, i.e. A549 (lung), MCF-7 (breast), A375 (melanoma) and HT-29 (colon). Results: Here, CA4 used as positive control. Among them, compounds 12b, 12c, 12f, 12g, 12h and 12j were exhibited promising activity than control drug. Conclusion: In conclusion, we have synthesized a novel series of 1,3,4-oxadiazole fused 1,3,4- thiazdiazole derivatives and their structures were confirmed by spectral analysis." @default.
• W2898946950 created "2018-11-09" @default.
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• W2898946950 date "2019-05-24" @default.
• W2898946950 modified "2023-10-13" @default.
• W2898946950 title "Novel 1,3,4-Oxadiazole Fused Thiadiazole Derivatives: Synthesis and study of Anticancer Activities" @default.
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• W2898946950 doi "https://doi.org/10.2174/1570180816666181031125946" @default.
• W2898946950 hasPublicationYear "2019" @default.
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