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• W2898949892 abstract "In addition to T cell-dependent (TD) Ab responses, T cells can also regulate T cell-independent (TI) B cell responses in the absence of a specific major histocompatibility complex (MHC) class II and antigenic peptide-based interaction between T and B cells. The elucidation of T cells capable of supporting TI Ab responses is important for understanding the cellular mechanism of different types of TI Ab responses. Natural killer T (NKT) cells represent 1 type of helper T cells involved in TI Ab responses and more candidate helper T cells responsible for TI Ab responses may also include γδ T cells and recently reported B-1 helper CD4+ T cells. Marginal zone (MZ) B and B-1 cells, 2 major innate-like B cell subsets considered to function independently of T cells, interact with innate-like T cells. Whereas MZ B and NKT cells interact mutually for a rapid response to blood-borne infection, peritoneal memory phenotype CD49dhighCD4+ T cells support natural Ab secretion by B-1 cells. Here the role of innate-like T cells in the so-called TI Ab response is discussed. To accommodate the involvement of T cells in the TI Ab responses, we suggest an expanded classification of TD Ab responses that incorporate cognate and non-cognate B cell help by innate-like T cells." @default.
• W2898949892 created "2018-11-09" @default.
• W2898949892 creator A5087034880 @default.
• W2898949892 creator A5090766797 @default.
• W2898949892 date "2018-01-01" @default.
• W2898949892 modified "2023-09-24" @default.
• W2898949892 title "Expansion and Sub-Classification of T Cell-Dependent Antibody Responses to Encompass the Role of Innate-Like T Cells in Antibody Responses" @default.
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• W2898949892 doi "https://doi.org/10.4110/in.2018.18.e34" @default.
• W2898949892 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6215906" @default.
• W2898949892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30402329" @default.
• W2898949892 hasPublicationYear "2018" @default.
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