FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898950757> ?p ?o ?g. }

• W2898950757 endingPage "7" @default.
• W2898950757 startingPage "1" @default.
• W2898950757 abstract "A mutant L206F/P207F/L259F of Talaromyces thermophilus lipase (TTL) exhibited high hydrolytic activity towards 2-carboxyethyl-3-cyano-5-methylhexanoic acid ethyl ester (CNDE) for synthesis of ( S )-2-carboxyethyl-3-cyano-5-methylhexanoic acid ( S -CCMA), a key chiral intermediate of pregabalin. However, low conversion at high CNDE concentration and unreusability of the free TTL mutant restricted its industrial applications. In this study, the TTL mutant was immobilized onto epoxy resin and its catalytic properties for kinetic resolution of CNDE were investigated. Under the optimized conditions, the immobilized lipase exhibited an increased catalytic efficiency even at a CNDE concentration of 3 M with 49.7% conversion and 95% <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mi>e</mml:mi><mml:msub><mml:mrow><mml:mi>e</mml:mi></mml:mrow><mml:mrow><mml:mi mathvariant=normal>p</mml:mi></mml:mrow></mml:msub></mml:math>. The conversion retained higher than 46.3% even after 10 times repeated use of the immobilized lipase in n -heptane-water biphasic system. These results demonstrated great potential of the immobilized TTL mutant for industrial production of the chiral intermediate of pregabalin." @default.
• W2898950757 created "2018-11-09" @default.
• W2898950757 creator A5000295665 @default.
• W2898950757 creator A5044617581 @default.
• W2898950757 creator A5054986036 @default.
• W2898950757 creator A5070021680 @default.
• W2898950757 date "2018-11-01" @default.
• W2898950757 modified "2023-10-17" @default.
• W2898950757 title "Efficient Biocatalytic Synthesis of Chiral Intermediate of Pregabalin Using Immobilized Talaromyces thermophilus Lipase" @default.
• W2898950757 cites W1178479038 @default.
• W2898950757 cites W1921804194 @default.
• W2898950757 cites W1967815494 @default.
• W2898950757 cites W1972649062 @default.
• W2898950757 cites W1980840970 @default.
• W2898950757 cites W1986394801 @default.
• W2898950757 cites W2001290593 @default.
• W2898950757 cites W2006019173 @default.
• W2898950757 cites W2011380635 @default.
• W2898950757 cites W2026147104 @default.
• W2898950757 cites W2043012086 @default.
• W2898950757 cites W2046937606 @default.
• W2898950757 cites W2050161736 @default.
• W2898950757 cites W2052668363 @default.
• W2898950757 cites W2062921979 @default.
• W2898950757 cites W2071152194 @default.
• W2898950757 cites W2079988365 @default.
• W2898950757 cites W2088403384 @default.
• W2898950757 cites W2090962483 @default.
• W2898950757 cites W2128635872 @default.
• W2898950757 cites W2188263579 @default.
• W2898950757 cites W2300883580 @default.
• W2898950757 cites W2402121505 @default.
• W2898950757 cites W2411743850 @default.
• W2898950757 cites W2470609715 @default.
• W2898950757 cites W2508084286 @default.
• W2898950757 cites W2528689474 @default.
• W2898950757 cites W2541401161 @default.
• W2898950757 cites W2580018907 @default.
• W2898950757 cites W2589016586 @default.
• W2898950757 cites W2740104529 @default.
• W2898950757 cites W2751746672 @default.
• W2898950757 cites W2759687925 @default.
• W2898950757 cites W2782876186 @default.
• W2898950757 cites W2884738621 @default.
• W2898950757 cites W4293247451 @default.
• W2898950757 doi "https://doi.org/10.1155/2018/6192059" @default.
• W2898950757 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6236560" @default.
• W2898950757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30515409" @default.
• W2898950757 hasPublicationYear "2018" @default.
• W2898950757 type Work @default.
• W2898950757 sameAs 2898950757 @default.
• W2898950757 citedByCount "4" @default.
• W2898950757 countsByYear W28989507572019 @default.
• W2898950757 countsByYear W28989507572020 @default.
• W2898950757 countsByYear W28989507572022 @default.
• W2898950757 crossrefType "journal-article" @default.
• W2898950757 hasAuthorship W2898950757A5000295665 @default.
• W2898950757 hasAuthorship W2898950757A5044617581 @default.
• W2898950757 hasAuthorship W2898950757A5054986036 @default.
• W2898950757 hasAuthorship W2898950757A5070021680 @default.
• W2898950757 hasBestOaLocation W28989507571 @default.
• W2898950757 hasConcept C146686406 @default.
• W2898950757 hasConcept C161790260 @default.
• W2898950757 hasConcept C178790620 @default.
• W2898950757 hasConcept C181199279 @default.
• W2898950757 hasConcept C185592680 @default.
• W2898950757 hasConcept C2779697368 @default.
• W2898950757 hasConcept C28173026 @default.
• W2898950757 hasConcept C43617362 @default.
• W2898950757 hasConcept C94412978 @default.
• W2898950757 hasConceptScore W2898950757C146686406 @default.
• W2898950757 hasConceptScore W2898950757C161790260 @default.
• W2898950757 hasConceptScore W2898950757C178790620 @default.
• W2898950757 hasConceptScore W2898950757C181199279 @default.
• W2898950757 hasConceptScore W2898950757C185592680 @default.
• W2898950757 hasConceptScore W2898950757C2779697368 @default.
• W2898950757 hasConceptScore W2898950757C28173026 @default.
• W2898950757 hasConceptScore W2898950757C43617362 @default.
• W2898950757 hasConceptScore W2898950757C94412978 @default.
• W2898950757 hasFunder F4320338464 @default.
• W2898950757 hasLocation W28989507571 @default.
• W2898950757 hasLocation W28989507572 @default.
• W2898950757 hasLocation W28989507573 @default.
• W2898950757 hasLocation W28989507574 @default.
• W2898950757 hasOpenAccess W2898950757 @default.
• W2898950757 hasPrimaryLocation W28989507571 @default.
• W2898950757 hasRelatedWork W1970534676 @default.
• W2898950757 hasRelatedWork W1987147838 @default.
• W2898950757 hasRelatedWork W1991159922 @default.
• W2898950757 hasRelatedWork W1998079171 @default.
• W2898950757 hasRelatedWork W2035404708 @default.
• W2898950757 hasRelatedWork W2044335989 @default.
• W2898950757 hasRelatedWork W2302492605 @default.
• W2898950757 hasRelatedWork W2561265080 @default.
• W2898950757 hasRelatedWork W2951652524 @default.
• W2898950757 hasRelatedWork W3016963443 @default.
• W2898950757 hasVolume "2018" @default.
• W2898950757 isParatext "false" @default.

• next