Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898953399> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2898953399 endingPage "890" @default.
- W2898953399 startingPage "883" @default.
- W2898953399 abstract "Myelin protein zero-like protein 1 (MPZL1) is a member of the immunoglobulin superfamily, and is also a receptor of concanavalin A (ConA). MPZL1 is upregulated in hepatocellular carcinoma (HCC) and accelerates migration of HCC cells. However, function of MPZL1 as a receptor of ConA and its role in HCC development are largely unknown. To elucidate the functional basis, we have determined the crystal structure of the extracellular domain of MPZL1 at 2.7 Å resolution. Overall, it folds like a typical immunoglobulin variable-like domain that is much like MPZ. Unexpectedly, we found Asn50 is a unique glycosylation site and the glycosylation mediates its interaction with ConA. Furthermore, we also found that MPZL1 exists as a homodimer in the crystal, in which hydrogen bonds between Ser86 and Val145 play an important role. Our results demonstrate that glycosylation of Asn50 is essential for its function as a receptor of ConA. We propose that dimerization of MPZL1 participates in control of its signal transmission in cell adhesion." @default.
- W2898953399 created "2018-11-09" @default.
- W2898953399 creator A5029224349 @default.
- W2898953399 creator A5053880675 @default.
- W2898953399 creator A5060284538 @default.
- W2898953399 creator A5078805296 @default.
- W2898953399 date "2018-12-01" @default.
- W2898953399 modified "2023-10-14" @default.
- W2898953399 title "Structural and biochemical studies of the extracellular domain of Myelin protein zero-like protein 1" @default.
- W2898953399 cites W1966131094 @default.
- W2898953399 cites W1979753188 @default.
- W2898953399 cites W1981180578 @default.
- W2898953399 cites W1982327997 @default.
- W2898953399 cites W2004374847 @default.
- W2898953399 cites W2006271846 @default.
- W2898953399 cites W2017084799 @default.
- W2898953399 cites W2018701545 @default.
- W2898953399 cites W2037179685 @default.
- W2898953399 cites W2040239455 @default.
- W2898953399 cites W2041140317 @default.
- W2898953399 cites W2056830859 @default.
- W2898953399 cites W2061730897 @default.
- W2898953399 cites W2064997769 @default.
- W2898953399 cites W2069068447 @default.
- W2898953399 cites W2074968543 @default.
- W2898953399 cites W2167244078 @default.
- W2898953399 cites W2169592718 @default.
- W2898953399 cites W2755687768 @default.
- W2898953399 doi "https://doi.org/10.1016/j.bbrc.2018.10.161" @default.
- W2898953399 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30392906" @default.
- W2898953399 hasPublicationYear "2018" @default.
- W2898953399 type Work @default.
- W2898953399 sameAs 2898953399 @default.
- W2898953399 citedByCount "4" @default.
- W2898953399 countsByYear W28989533992019 @default.
- W2898953399 countsByYear W28989533992020 @default.
- W2898953399 countsByYear W28989533992022 @default.
- W2898953399 crossrefType "journal-article" @default.
- W2898953399 hasAuthorship W2898953399A5029224349 @default.
- W2898953399 hasAuthorship W2898953399A5053880675 @default.
- W2898953399 hasAuthorship W2898953399A5060284538 @default.
- W2898953399 hasAuthorship W2898953399A5078805296 @default.
- W2898953399 hasConcept C149774189 @default.
- W2898953399 hasConcept C170493617 @default.
- W2898953399 hasConcept C185592680 @default.
- W2898953399 hasConcept C19869320 @default.
- W2898953399 hasConcept C202751555 @default.
- W2898953399 hasConcept C2777313579 @default.
- W2898953399 hasConcept C28406088 @default.
- W2898953399 hasConcept C55493867 @default.
- W2898953399 hasConcept C86803240 @default.
- W2898953399 hasConcept C91682701 @default.
- W2898953399 hasConcept C95444343 @default.
- W2898953399 hasConceptScore W2898953399C149774189 @default.
- W2898953399 hasConceptScore W2898953399C170493617 @default.
- W2898953399 hasConceptScore W2898953399C185592680 @default.
- W2898953399 hasConceptScore W2898953399C19869320 @default.
- W2898953399 hasConceptScore W2898953399C202751555 @default.
- W2898953399 hasConceptScore W2898953399C2777313579 @default.
- W2898953399 hasConceptScore W2898953399C28406088 @default.
- W2898953399 hasConceptScore W2898953399C55493867 @default.
- W2898953399 hasConceptScore W2898953399C86803240 @default.
- W2898953399 hasConceptScore W2898953399C91682701 @default.
- W2898953399 hasConceptScore W2898953399C95444343 @default.
- W2898953399 hasFunder F4320321001 @default.
- W2898953399 hasIssue "4" @default.
- W2898953399 hasLocation W28989533991 @default.
- W2898953399 hasLocation W28989533992 @default.
- W2898953399 hasOpenAccess W2898953399 @default.
- W2898953399 hasPrimaryLocation W28989533991 @default.
- W2898953399 hasRelatedWork W1965252847 @default.
- W2898953399 hasRelatedWork W2000772846 @default.
- W2898953399 hasRelatedWork W2027991517 @default.
- W2898953399 hasRelatedWork W2075883802 @default.
- W2898953399 hasRelatedWork W2087712459 @default.
- W2898953399 hasRelatedWork W2093830420 @default.
- W2898953399 hasRelatedWork W2173333770 @default.
- W2898953399 hasRelatedWork W2898953399 @default.
- W2898953399 hasRelatedWork W3014647939 @default.
- W2898953399 hasRelatedWork W65425793 @default.
- W2898953399 hasVolume "506" @default.
- W2898953399 isParatext "false" @default.
- W2898953399 isRetracted "false" @default.
- W2898953399 magId "2898953399" @default.
- W2898953399 workType "article" @default.