FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898976251> ?p ?o ?g. }

• W2898976251 endingPage "86" @default.
• W2898976251 startingPage "76" @default.
• W2898976251 abstract "Retinal pigment epithelial (RPE) cells are highly specialized neural cells that have several functions essential for vision. Progressive deterioration of RPE cells in elderly individuals can result in visual impairment and ultimately the blinding disease age-related macular degeneration. Subretinal transplantation of stem cell-derived RPE cell suspensions is being explored as a strategy to recover the damaged retina and improve vision. This approach may be improved by developing a vehicle that increases postinjection cell viability and distribution and integration of RPE cells. In this study, Food and Drug Administration-approved natural polymers, including alginate, methylcellulose, and hyaluronic acid (HA), were examined for performance as cell vehicles for adult human RPE stem cells (RPESCs). We compared the effect of RPESC storage as a cell suspension in these delivery vehicles for 1–96 hr at different temperatures on subsequent cell performance in a cell culture model. RPESC survival, attachment, distribution, proliferation, and differentiation into RPE cells were monitored by microscopy over the course of 8 weeks. Our in vitro results demonstrate that RPESC suspension in a 0.2% HA solution promotes better initial cell distribution, proliferation, cobblestone formation, and expression of RPE cell markers (microphthalmia-associated transcription factor and orthodenticle homeobox 2) after 96 hr of storage. These data suggest that HA addition to the vehicle can significantly enhance RPESC performance in vitro and is a promising strategy to pursue an improved delivery vehicle supporting in vivo RPE cell transplantation." @default.
• W2898976251 created "2018-11-09" @default.
• W2898976251 creator A5025501620 @default.
• W2898976251 creator A5041077582 @default.
• W2898976251 creator A5049914021 @default.
• W2898976251 creator A5070222700 @default.
• W2898976251 creator A5084751732 @default.
• W2898976251 creator A5091124408 @default.
• W2898976251 date "2018-12-05" @default.
• W2898976251 modified "2023-09-27" @default.
• W2898976251 title "Screening and optimization of potential injection vehicles for storage of retinal pigment epithelial stem cell before transplantation" @default.
• W2898976251 cites W1539945441 @default.
• W2898976251 cites W1969242143 @default.
• W2898976251 cites W1986543208 @default.
• W2898976251 cites W1988138442 @default.
• W2898976251 cites W1992446886 @default.
• W2898976251 cites W1992915966 @default.
• W2898976251 cites W2003504387 @default.
• W2898976251 cites W2004526409 @default.
• W2898976251 cites W2010977640 @default.
• W2898976251 cites W2014047131 @default.
• W2898976251 cites W2016602601 @default.
• W2898976251 cites W2019605249 @default.
• W2898976251 cites W2025793225 @default.
• W2898976251 cites W2045048112 @default.
• W2898976251 cites W2052196137 @default.
• W2898976251 cites W2052765343 @default.
• W2898976251 cites W2062460463 @default.
• W2898976251 cites W2066998095 @default.
• W2898976251 cites W2072127633 @default.
• W2898976251 cites W2084949203 @default.
• W2898976251 cites W2085054052 @default.
• W2898976251 cites W2091315047 @default.
• W2898976251 cites W2092167465 @default.
• W2898976251 cites W2098193566 @default.
• W2898976251 cites W2111274886 @default.
• W2898976251 cites W2114914263 @default.
• W2898976251 cites W2124789204 @default.
• W2898976251 cites W2127688669 @default.
• W2898976251 cites W2140150317 @default.
• W2898976251 cites W2149884610 @default.
• W2898976251 cites W2149968101 @default.
• W2898976251 cites W2151772282 @default.
• W2898976251 cites W2157500454 @default.
• W2898976251 cites W2190462636 @default.
• W2898976251 cites W2190948487 @default.
• W2898976251 cites W2225516726 @default.
• W2898976251 cites W2225714282 @default.
• W2898976251 cites W2254056921 @default.
• W2898976251 cites W2294783182 @default.
• W2898976251 cites W2322363882 @default.
• W2898976251 cites W2334480817 @default.
• W2898976251 cites W2343804072 @default.
• W2898976251 cites W2398798916 @default.
• W2898976251 cites W2406649044 @default.
• W2898976251 cites W2476085202 @default.
• W2898976251 cites W2547645779 @default.
• W2898976251 cites W2601350462 @default.
• W2898976251 cites W2625602399 @default.
• W2898976251 cites W2777997419 @default.
• W2898976251 cites W46824281 @default.
• W2898976251 doi "https://doi.org/10.1002/term.2770" @default.
• W2898976251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30381899" @default.
• W2898976251 hasPublicationYear "2018" @default.
• W2898976251 type Work @default.
• W2898976251 sameAs 2898976251 @default.
• W2898976251 citedByCount "4" @default.
• W2898976251 countsByYear W28989762512020 @default.
• W2898976251 countsByYear W28989762512021 @default.
• W2898976251 countsByYear W28989762512022 @default.
• W2898976251 crossrefType "journal-article" @default.
• W2898976251 hasAuthorship W2898976251A5025501620 @default.
• W2898976251 hasAuthorship W2898976251A5041077582 @default.
• W2898976251 hasAuthorship W2898976251A5049914021 @default.
• W2898976251 hasAuthorship W2898976251A5070222700 @default.
• W2898976251 hasAuthorship W2898976251A5084751732 @default.
• W2898976251 hasAuthorship W2898976251A5091124408 @default.
• W2898976251 hasBestOaLocation W28989762511 @default.
• W2898976251 hasConcept C118487528 @default.
• W2898976251 hasConcept C141071460 @default.
• W2898976251 hasConcept C1491633281 @default.
• W2898976251 hasConcept C169760540 @default.
• W2898976251 hasConcept C185592680 @default.
• W2898976251 hasConcept C2776403814 @default.
• W2898976251 hasConcept C2777093970 @default.
• W2898976251 hasConcept C2778024200 @default.
• W2898976251 hasConcept C2780827179 @default.
• W2898976251 hasConcept C28328180 @default.
• W2898976251 hasConcept C2911091166 @default.
• W2898976251 hasConcept C53227056 @default.
• W2898976251 hasConcept C55493867 @default.
• W2898976251 hasConcept C71924100 @default.
• W2898976251 hasConcept C86803240 @default.
• W2898976251 hasConcept C95444343 @default.
• W2898976251 hasConceptScore W2898976251C118487528 @default.
• W2898976251 hasConceptScore W2898976251C141071460 @default.
• W2898976251 hasConceptScore W2898976251C1491633281 @default.
• W2898976251 hasConceptScore W2898976251C169760540 @default.

• next