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- W2898982839 abstract "Objectives: We aim to study the relation between plasma homocysteine level and left ventricle hypertrophy and kidney damage among patients with primary hypertension. Methods: Patients with hypertension that were hospitalized during 2013.3–2016.1 in our center were taken as the study objects. The blood biochemistry and Hcy index of patients were recorded. The target-organ damage degrees of patients were evaluated by ultrasonic cardiography, electrocardiogram, 24-hour ambulatory blood pressure and microalbuminuria/creatinine. The influence of different Hcy levels on target-organ damage was compared. We divided patients into 3 groups by Hcy level (<10umol/L,Hcy 10–14.99umol/L,Hcy≥15). We also divided the patients into 2 groups by whether they had kidney funciton decrease or mieroalbuminuria or not. Results: (1) After correcting factors including age, BMI, blood fat, blood sugar, living habits, as Hcy increased by one level, LVMI increased by 4.89 g/m2. (2)After adjusting factors including age, sex, BMI, smoking, drinking, FBG, H1Alc, TC, TG, HDL-C, LDL-C, 24 h MAP, it was found that Hcy was the risk factor for left ventricular hypertrophy (OR = 2.89,P = 0.000).(3)After adjusting age, sex, BMI, 24hMAP, eGFR, FBG, TC, TG, HDL-C, LDL-C, smoking, drinking, as Hcy increased by one level, eGFR decreased by 6.84 ml/min/1.73m2 (P = 0.000) and the serum creatinine increased by 9.39umol/L (P = 0.000) and risk of suffering from chronic kidney disease increased by 4.79 times (P = 0.001). (4) After adjusting age, sex, BMI, MAP, eGFR, Diabetes, TC, TG, HDL-C, LDL-C, smoking, as Hcy increased by one level, UACR increased by 13.07 mg/g (P = 0.000) and the risk of microalbuminuria increased by 2.63 times (P = 0.001). Conclusion: Hcy level is the risk factor of left ventricular hypertrophy and chronic kidney disease in primary hypertension." @default.
- W2898982839 created "2018-11-09" @default.
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- W2898982839 date "2018-10-01" @default.
- W2898982839 modified "2023-09-25" @default.
- W2898982839 title "A13501 Study on correlation between plasma homocysteinemia level and target organ damage in patients with primary hypertension" @default.
- W2898982839 doi "https://doi.org/10.1097/01.hjh.0000548905.41602.ea" @default.
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