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• W2898984886 abstract "Abstract APOL1 risk alleles associate with chronic kidney disease in African Americans, but the mechanisms remain to be fully understood. We show that APOL1 risk alleles activate protein kinase R (PKR) in cultured cells and transgenic mice. This effect is preserved when a premature stop codon is introduced to APOL1 risk alleles, suggesting that APOL1 RNA but not protein is required for the effect. Podocyte expression of APOL1 risk allele RNA, but not protein, in transgenic mice induces glomerular injury and proteinuria. Structural analysis of the APOL1 RNA shows that the risk variants possess secondary structure serving as a scaffold for tandem PKR binding and activation. These findings provide a mechanism by which APOL1 variants damage podocytes and suggest novel therapeutic strategies." @default.
• W2898984886 created "2018-11-09" @default.
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• W2898984886 date "2018-11-07" @default.
• W2898984886 modified "2023-10-12" @default.
• W2898984886 title "APOL1 risk allele RNA contributes to renal toxicity by activating protein kinase R" @default.
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• W2898984886 doi "https://doi.org/10.1038/s42003-018-0188-2" @default.
• W2898984886 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6220249" @default.
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