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- W2898987589 abstract "Protein disulfide isomerases (PDIs) are oxidoreductases that are involved in catalysis of disulfide bonds in various proteins. Previous study from our laboratory reported that PDIA3 catalyzes formation of disulfide bonds in death receptor Fas and regulate allergen induced lung fibrosis via catalyzing the disulfide bonds in pro-fibrotic growth factors and oligomerization of BAK. Since PDIA3 is involved in catalysis of disulfide bonds in key players of lung fibrosis. Our objective in the current study was to elucidate the role of PDIA3 in Idiopathic Pulmonary Fibrosis (IPF) a progressive disease with an estimated median survival time of 5 years following diagnosis. Our analyses showed that an increase in PDIA3 transcripts and protein in lung specimens of IPF as compared to non-IPF subjects. This increase in PDIA3 was also apparent in a bleomycin induced mouse model of pulmonary fibrosis. Next, to evaluate the role of PDIA3 in pulmonary fibrosis we generated a mouse line capable of deleting PDIA3 (DEpi-Pdia3) upon doxycycline (dox) treatment in lung epithelial cells. The DEpi-Pdia3 and their litter mate controls (Ctr that cannot delete PDIA3) were challenged with bleomycin or PBS as reagent control. After 14 days the experimental mice were provided with dox treatment to ablate PDIA3 in lung epithelial cells. This experiment for the first time showed that deletion of PDIA3 attenuated bleomycin induced lung fibrosis in DEpi-Pdia3 mice as compared to Ctr mice. This decrease in lung fibrosis was also marked by decrease in apoptotic markers and other fibrotic markers. Collectively our data indicates that PDIA3 plays an important role in development of pulmonary fibrosis potentially via formation of disulfide bonds in pro-apoptotic Fas and BAK proteins and as well as in pro-fibrotic growth factors. We believe that a future strategy to inhibit PDIA3 in the lung would be potentially beneficial in treating IPF patients." @default.
- W2898987589 created "2018-11-09" @default.
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- W2898987589 date "2018-11-01" @default.
- W2898987589 modified "2023-10-12" @default.
- W2898987589 title "Ablation of PDIA3 alleviates pulmonary fibrosis in mice" @default.
- W2898987589 doi "https://doi.org/10.1016/j.freeradbiomed.2018.10.029" @default.
- W2898987589 hasPublicationYear "2018" @default.
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