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- W2898989960 abstract "High titers of pathogenic autoantibodies are a hallmark of many autoimmune diseases. However, much remains unknown about the self-reactive plasma cells that are key mediators of disease. We propose a model in which the varying efficacy of precursor B cell depletion for the treatment of humoral autoimmunity can be explained by differences in the relative contributions of pathogenic antibodies by short-lived versus long-lived plasma cells. Beyond therapeutic considerations, this model suggests that we can infer the cellular source of disease-associated autoantibodies by the durability of serum titers following B cell depletion. Data from clinical trials and animal models across different autoimmune diseases may provide useful insights into the lifespan, lifestyle and fate of autoreactive plasma cells." @default.
- W2898989960 created "2018-11-09" @default.
- W2898989960 creator A5027470095 @default.
- W2898989960 creator A5067571710 @default.
- W2898989960 creator A5091563032 @default.
- W2898989960 date "2018-12-01" @default.
- W2898989960 modified "2023-10-03" @default.
- W2898989960 title "The long and the short of it: insights into the cellular source of autoantibodies as revealed by B cell depletion therapy" @default.
- W2898989960 cites W1516874144 @default.
- W2898989960 cites W1542547647 @default.
- W2898989960 cites W1550723234 @default.
- W2898989960 cites W1581336840 @default.
- W2898989960 cites W1633176708 @default.
- W2898989960 cites W1675831178 @default.
- W2898989960 cites W1731046649 @default.
- W2898989960 cites W1750939701 @default.
- W2898989960 cites W1963737717 @default.
- W2898989960 cites W1966362133 @default.
- W2898989960 cites W1983211634 @default.
- W2898989960 cites W1988928788 @default.
- W2898989960 cites W1989273660 @default.
- W2898989960 cites W1993290536 @default.
- W2898989960 cites W2005894429 @default.
- W2898989960 cites W2008762255 @default.
- W2898989960 cites W2010282370 @default.
- W2898989960 cites W2014523162 @default.
- W2898989960 cites W2020074258 @default.
- W2898989960 cites W2021990477 @default.
- W2898989960 cites W2024235155 @default.
- W2898989960 cites W2024263224 @default.
- W2898989960 cites W2024308747 @default.
- W2898989960 cites W2025220396 @default.
- W2898989960 cites W2028514870 @default.
- W2898989960 cites W2034528584 @default.
- W2898989960 cites W2040876247 @default.
- W2898989960 cites W2042927558 @default.
- W2898989960 cites W2046330020 @default.
- W2898989960 cites W2046517086 @default.
- W2898989960 cites W2051380725 @default.
- W2898989960 cites W2054663993 @default.
- W2898989960 cites W2057332383 @default.
- W2898989960 cites W2078610240 @default.
- W2898989960 cites W2085412199 @default.
- W2898989960 cites W2088446845 @default.
- W2898989960 cites W2097531433 @default.
- W2898989960 cites W2105835861 @default.
- W2898989960 cites W2114850377 @default.
- W2898989960 cites W2117335168 @default.
- W2898989960 cites W2120292982 @default.
- W2898989960 cites W2120741582 @default.
- W2898989960 cites W2123082276 @default.
- W2898989960 cites W2125086093 @default.
- W2898989960 cites W2128488331 @default.
- W2898989960 cites W2139211750 @default.
- W2898989960 cites W2141812411 @default.
- W2898989960 cites W2156961356 @default.
- W2898989960 cites W2160684214 @default.
- W2898989960 cites W2162411149 @default.
- W2898989960 cites W2289710622 @default.
- W2898989960 cites W2317276018 @default.
- W2898989960 cites W2321809676 @default.
- W2898989960 cites W2360020331 @default.
- W2898989960 cites W2418683916 @default.
- W2898989960 cites W2510979876 @default.
- W2898989960 cites W2582624932 @default.
- W2898989960 cites W2588368793 @default.
- W2898989960 cites W2592697450 @default.
- W2898989960 cites W2602517913 @default.
- W2898989960 cites W2605871488 @default.
- W2898989960 cites W2607741101 @default.
- W2898989960 cites W2612649182 @default.
- W2898989960 cites W2613529089 @default.
- W2898989960 cites W2726907951 @default.
- W2898989960 cites W2737828297 @default.
- W2898989960 cites W2751350739 @default.
- W2898989960 cites W2767440408 @default.
- W2898989960 cites W2770797413 @default.
- W2898989960 cites W2773203873 @default.
- W2898989960 cites W2783702021 @default.
- W2898989960 cites W2787827666 @default.
- W2898989960 cites W2793352806 @default.
- W2898989960 cites W2795707233 @default.
- W2898989960 cites W2802625767 @default.
- W2898989960 cites W2807637103 @default.
- W2898989960 cites W4292232933 @default.
- W2898989960 cites W917249719 @default.
- W2898989960 doi "https://doi.org/10.1016/j.coi.2018.10.008" @default.
- W2898989960 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6289281" @default.
- W2898989960 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30390507" @default.
- W2898989960 hasPublicationYear "2018" @default.
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