FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898993208> ?p ?o ?g. }

• W2898993208 endingPage "87" @default.
• W2898993208 startingPage "79" @default.
• W2898993208 abstract "As one of the most abundant toxic contaminants in the atmosphere, carbon monoxide (CO) plays a significant role in toxicology and public health. Every year, around half of the accidental non-fire-related poisoning deaths are attributed to CO in the USA, UK and many other countries. However, due to the non-specificity of the symptoms and often encountered inconsistency of these with the results obtained from measurements of the biomarker for CO poisonings, carboxyhemoglobin (COHb), there is a high rate of misdiagnoses. The mechanism of toxicity of CO includes not only the reduced transport of oxygen caused by COHb but also the impairment of cellular respiration and activation of oxidative metabolism by binding to other proteins. Therefore, in this study we propose the measurement of the total amount of CO in blood (TBCO) by airtight gas syringe-gas chromatography-mass spectrometry (AGS-GC-MS) as an alternative to COHb for the determination of CO exposures. The method is validated for a clinical range with TBCO concentrations of 1.63-104 nmol/mL of headspace (HS) (0.65-41.6 μmol/mL blood). The limit of quantification was found between 2 and 5 nmol/mL HS (0.8 and 2 μmol/mL blood). The method is applied to a cohort of 13 patients, who were exposed to CO under controlled conditions, and the results are compared to those obtained by CO-oximetry. Furthermore, samples were compared before and after a flushing step to remove excess CO. Results showed a significant decrease in TBCO when samples were flushed (10-60%), whereas no constant trend was observed for COHb. Therefore, measurement of TBCO by AGS-GC-MS suggests the presence of more dissolved CO than previously known. This constitutes a first step into the acknowledgment of a possibly significant amount of CO present not in the form of COHb, but as free CO, which might help explain the incongruences with symptoms and decrease misdiagnoses." @default.
• W2898993208 created "2018-11-09" @default.
• W2898993208 creator A5017128533 @default.
• W2898993208 creator A5019071645 @default.
• W2898993208 date "2018-10-29" @default.
• W2898993208 modified "2023-10-18" @default.
• W2898993208 title "Total Blood Carbon Monoxide: Alternative to Carboxyhemoglobin as Biological Marker for Carbon Monoxide Poisoning Determination" @default.
• W2898993208 cites W1747821000 @default.
• W2898993208 cites W1922743139 @default.
• W2898993208 cites W1926872294 @default.
• W2898993208 cites W1963061073 @default.
• W2898993208 cites W1975135322 @default.
• W2898993208 cites W1980977789 @default.
• W2898993208 cites W1981165639 @default.
• W2898993208 cites W1981596580 @default.
• W2898993208 cites W1982165241 @default.
• W2898993208 cites W1990351686 @default.
• W2898993208 cites W1993912190 @default.
• W2898993208 cites W1995657492 @default.
• W2898993208 cites W1998090143 @default.
• W2898993208 cites W2005283816 @default.
• W2898993208 cites W2018490221 @default.
• W2898993208 cites W2018695645 @default.
• W2898993208 cites W2023571733 @default.
• W2898993208 cites W2025229307 @default.
• W2898993208 cites W2032519000 @default.
• W2898993208 cites W2039684070 @default.
• W2898993208 cites W2043827724 @default.
• W2898993208 cites W2048979722 @default.
• W2898993208 cites W2054037600 @default.
• W2898993208 cites W2077158875 @default.
• W2898993208 cites W2089114417 @default.
• W2898993208 cites W2096555843 @default.
• W2898993208 cites W2096683884 @default.
• W2898993208 cites W2105092111 @default.
• W2898993208 cites W2106090635 @default.
• W2898993208 cites W2108991437 @default.
• W2898993208 cites W2108997493 @default.
• W2898993208 cites W2109286815 @default.
• W2898993208 cites W2114250354 @default.
• W2898993208 cites W2118143249 @default.
• W2898993208 cites W2118632097 @default.
• W2898993208 cites W2140860979 @default.
• W2898993208 cites W2142303940 @default.
• W2898993208 cites W2144534594 @default.
• W2898993208 cites W2148106407 @default.
• W2898993208 cites W2152053613 @default.
• W2898993208 cites W2154208643 @default.
• W2898993208 cites W2159478157 @default.
• W2898993208 cites W2162146601 @default.
• W2898993208 cites W2225136811 @default.
• W2898993208 cites W2324407520 @default.
• W2898993208 cites W2325968107 @default.
• W2898993208 cites W2410570996 @default.
• W2898993208 cites W2532034722 @default.
• W2898993208 cites W2606150076 @default.
• W2898993208 cites W2614771450 @default.
• W2898993208 cites W2731227107 @default.
• W2898993208 cites W2774509293 @default.
• W2898993208 cites W2780417766 @default.
• W2898993208 cites W2784383102 @default.
• W2898993208 cites W2804811261 @default.
• W2898993208 cites W2951661263 @default.
• W2898993208 cites W43893483 @default.
• W2898993208 doi "https://doi.org/10.1093/jat/bky084" @default.
• W2898993208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30371866" @default.
• W2898993208 hasPublicationYear "2018" @default.
• W2898993208 type Work @default.
• W2898993208 sameAs 2898993208 @default.
• W2898993208 citedByCount "10" @default.
• W2898993208 countsByYear W28989932082019 @default.
• W2898993208 countsByYear W28989932082020 @default.
• W2898993208 countsByYear W28989932082021 @default.
• W2898993208 countsByYear W28989932082022 @default.
• W2898993208 countsByYear W28989932082023 @default.
• W2898993208 crossrefType "journal-article" @default.
• W2898993208 hasAuthorship W2898993208A5017128533 @default.
• W2898993208 hasAuthorship W2898993208A5019071645 @default.
• W2898993208 hasBestOaLocation W28989932081 @default.
• W2898993208 hasConcept C105702510 @default.
• W2898993208 hasConcept C107872376 @default.
• W2898993208 hasConcept C161790260 @default.
• W2898993208 hasConcept C182215343 @default.
• W2898993208 hasConcept C185592680 @default.
• W2898993208 hasConcept C194828623 @default.
• W2898993208 hasConcept C2776378800 @default.
• W2898993208 hasConcept C2778917026 @default.
• W2898993208 hasConcept C2781119925 @default.
• W2898993208 hasConcept C3017944768 @default.
• W2898993208 hasConcept C43617362 @default.
• W2898993208 hasConcept C512735826 @default.
• W2898993208 hasConcept C55493867 @default.
• W2898993208 hasConcept C71924100 @default.
• W2898993208 hasConceptScore W2898993208C105702510 @default.
• W2898993208 hasConceptScore W2898993208C107872376 @default.
• W2898993208 hasConceptScore W2898993208C161790260 @default.
• W2898993208 hasConceptScore W2898993208C182215343 @default.
• W2898993208 hasConceptScore W2898993208C185592680 @default.

• next