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- W2899001078 abstract "Abstract Introduction Uterine leiomyoma (UL) are the most common tumours of the female uterus. They are responsible for gross morbidity and disproportionately affect black women. Evidence suggests that UL development is facilitated by genetic and hormonal stimuli as well as lifestyle, including obesity. One such genetic factor (SNP rs4247357) which was previously implicated in the predisposition of UL in Caucasians is investigated in this study, in a native Afro-Caribbean population. Methods The rs4247357 SNP was genotyped by performing polymerase chain reaction-restriction fragment length polymorphism in a case-control study comprised of 36 cases and 57 controls. Results Genotypic frequencies for CC, AC and AA genotypes were 25%, 50% and 25% respectively in the cases and 25%, 56% and 19% respectively, in the controls. The SNP was not found to be associated with UL risk (P > .05). However, among obese women in this population the risk of UL is increased with rs4247357. Conclusions This is the first measure of rs4247357 in a Caribbean population and coincides with a recent study in African- American women where no association was also found." @default.
- W2899001078 created "2018-11-09" @default.
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- W2899001078 date "2019-02-01" @default.
- W2899001078 modified "2023-10-17" @default.
- W2899001078 title "A preliminary study of fatty acid synthase gene and the risk of uterine leiomyoma in an Afro-Caribbean female population" @default.
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- W2899001078 doi "https://doi.org/10.1016/j.mgene.2018.10.011" @default.
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