Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899004524> ?p ?o ?g. }
- W2899004524 endingPage "1238" @default.
- W2899004524 startingPage "1232" @default.
- W2899004524 abstract "Thyroid hormone metabolites might affect the heart. The endogenous aminergic metabolite 3-iodothyronamine (T1am) reduces left ventricular ejection fraction (LVEF) in rodents. To investigate concentration of T1am and its association with LVEF and biomarkers of heart function in patients with chronic heart failure (CHF) without thyroid disease, including patients with cardiac cachexia (nonedematous weight loss >5% over 6 months). Cross-sectional study. CHF was characterized by LVEF <45% and symptoms. Three groups were included (n = 19 in each group, matched on age, sex, and kidney function): patients with cachexia (CAC), patients without (non-CAC), and control (C) patients with prior myocardial infarction and LVEF >45%. T1am was measured by a monoclonal antibody-based chemiluminescence immunoassay. N-amino terminal pro-BNP (NT-proBNP) concentrations were also analyzed. Mean (SD) LVEF: CAC, 32 ± 9%; non-CAC, 38 ± 8%; and C, 60 ± 8% (P < 0.0001). TSH, T4, and T3 levels did not differ between groups and did not correlate to T1am. Serum T1am (nmol/L) concentrations were higher in CHF: CAC (mean ± SD), 12.4 ± 6.6; non-CAC, 9.1 ± 5; and C, 7.3 ± 2.9. A negative association between T1am and LVEF was present after adjusting for sex, age, T3, and estimated glomerular filtration rate (P = 0.03). Further, serum T1am levels tended to be associated with NT-proBNP (P = 0.053). Serum T1am levels were increased in patients with CHF and numerically highest (although nonsignificant) in patients with cardiac cachexia. Increasing T1am concentrations were independently associated with reduced LVEF, suggesting a direct effect on the human heart." @default.
- W2899004524 created "2018-11-09" @default.
- W2899004524 creator A5008141462 @default.
- W2899004524 creator A5038349926 @default.
- W2899004524 creator A5051322889 @default.
- W2899004524 creator A5052536282 @default.
- W2899004524 creator A5053899216 @default.
- W2899004524 creator A5058224154 @default.
- W2899004524 creator A5072362865 @default.
- W2899004524 date "2018-10-31" @default.
- W2899004524 modified "2023-10-16" @default.
- W2899004524 title "Association Between 3-Iodothyronamine (T1<scp>am</scp>) Concentrations and Left Ventricular Function in Chronic Heart Failure" @default.
- W2899004524 cites W1580480511 @default.
- W2899004524 cites W1602307529 @default.
- W2899004524 cites W1808165721 @default.
- W2899004524 cites W1964925711 @default.
- W2899004524 cites W1966920893 @default.
- W2899004524 cites W1989823250 @default.
- W2899004524 cites W1994735484 @default.
- W2899004524 cites W1999610793 @default.
- W2899004524 cites W2029707360 @default.
- W2899004524 cites W2041509950 @default.
- W2899004524 cites W2045912880 @default.
- W2899004524 cites W2047289730 @default.
- W2899004524 cites W2059466080 @default.
- W2899004524 cites W2061216250 @default.
- W2899004524 cites W2064284473 @default.
- W2899004524 cites W2116291799 @default.
- W2899004524 cites W2134964824 @default.
- W2899004524 cites W2136133737 @default.
- W2899004524 cites W2139040536 @default.
- W2899004524 cites W2142011070 @default.
- W2899004524 cites W2143079214 @default.
- W2899004524 cites W2144352652 @default.
- W2899004524 cites W2152462131 @default.
- W2899004524 cites W2163317012 @default.
- W2899004524 cites W2165821124 @default.
- W2899004524 cites W2395950874 @default.
- W2899004524 cites W2473596099 @default.
- W2899004524 cites W2537831565 @default.
- W2899004524 cites W2548036931 @default.
- W2899004524 cites W2553575456 @default.
- W2899004524 cites W2568955016 @default.
- W2899004524 cites W2583643003 @default.
- W2899004524 cites W2585869774 @default.
- W2899004524 cites W2610330026 @default.
- W2899004524 cites W2620445037 @default.
- W2899004524 cites W2751633304 @default.
- W2899004524 cites W2773362812 @default.
- W2899004524 cites W633171671 @default.
- W2899004524 doi "https://doi.org/10.1210/jc.2018-01466" @default.
- W2899004524 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30383216" @default.
- W2899004524 hasPublicationYear "2018" @default.
- W2899004524 type Work @default.
- W2899004524 sameAs 2899004524 @default.
- W2899004524 citedByCount "9" @default.
- W2899004524 countsByYear W28990045242019 @default.
- W2899004524 countsByYear W28990045242020 @default.
- W2899004524 countsByYear W28990045242022 @default.
- W2899004524 crossrefType "journal-article" @default.
- W2899004524 hasAuthorship W2899004524A5008141462 @default.
- W2899004524 hasAuthorship W2899004524A5038349926 @default.
- W2899004524 hasAuthorship W2899004524A5051322889 @default.
- W2899004524 hasAuthorship W2899004524A5052536282 @default.
- W2899004524 hasAuthorship W2899004524A5053899216 @default.
- W2899004524 hasAuthorship W2899004524A5058224154 @default.
- W2899004524 hasAuthorship W2899004524A5072362865 @default.
- W2899004524 hasBestOaLocation W28990045241 @default.
- W2899004524 hasConcept C111566952 @default.
- W2899004524 hasConcept C121608353 @default.
- W2899004524 hasConcept C126322002 @default.
- W2899004524 hasConcept C134018914 @default.
- W2899004524 hasConcept C164705383 @default.
- W2899004524 hasConcept C2777704314 @default.
- W2899004524 hasConcept C2778198053 @default.
- W2899004524 hasConcept C2780074459 @default.
- W2899004524 hasConcept C500558357 @default.
- W2899004524 hasConcept C71315377 @default.
- W2899004524 hasConcept C71924100 @default.
- W2899004524 hasConcept C78085059 @default.
- W2899004524 hasConceptScore W2899004524C111566952 @default.
- W2899004524 hasConceptScore W2899004524C121608353 @default.
- W2899004524 hasConceptScore W2899004524C126322002 @default.
- W2899004524 hasConceptScore W2899004524C134018914 @default.
- W2899004524 hasConceptScore W2899004524C164705383 @default.
- W2899004524 hasConceptScore W2899004524C2777704314 @default.
- W2899004524 hasConceptScore W2899004524C2778198053 @default.
- W2899004524 hasConceptScore W2899004524C2780074459 @default.
- W2899004524 hasConceptScore W2899004524C500558357 @default.
- W2899004524 hasConceptScore W2899004524C71315377 @default.
- W2899004524 hasConceptScore W2899004524C71924100 @default.
- W2899004524 hasConceptScore W2899004524C78085059 @default.
- W2899004524 hasIssue "4" @default.
- W2899004524 hasLocation W28990045241 @default.
- W2899004524 hasLocation W28990045242 @default.
- W2899004524 hasOpenAccess W2899004524 @default.
- W2899004524 hasPrimaryLocation W28990045241 @default.
- W2899004524 hasRelatedWork W2091139515 @default.