Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899014944> ?p ?o ?g. }
- W2899014944 endingPage "96" @default.
- W2899014944 startingPage "96" @default.
- W2899014944 abstract "Neuroblastoma (NB) is the most common extracranial solid tumor in pediatrics, with rare occurrences of primary and metastatic tumors in the central nervous system (CNS). We previously reported the overexpression of the polo-like kinase 4 (PLK4) in embryonal brain tumors. PLK4 has also been found to be overexpressed in a variety of peripheral adult tumors and recently in peripheral NB. Here, we investigated PLK4 expression in NBs of the CNS (CNS-NB) and validated our findings by performing a multi-platform transcriptomic meta-analysis using publicly available data. We evaluated the PLK4 expression by quantitative real-time PCR (qRT-PCR) on the CNS-NB samples and compared the relative expression levels among other embryonal and non-embryonal brain tumors. The relative PLK4 expression levels of the NB samples were found to be significantly higher than the non-embryonal brain tumors (p-value < 0.0001 in both our samples and in public databases). Here, we expand upon our previous work that detected PLK4 overexpression in pediatric embryonal tumors to include CNS-NB. As we previously reported, inhibiting PLK4 in embryonal tumors led to decreased tumor cell proliferation, survival, invasion and migration in vitro and tumor growth in vivo, and therefore PLK4 may be a potential new therapeutic approach to CNS-NB." @default.
- W2899014944 created "2018-11-09" @default.
- W2899014944 creator A5016473426 @default.
- W2899014944 creator A5023971218 @default.
- W2899014944 creator A5027060903 @default.
- W2899014944 creator A5029649755 @default.
- W2899014944 creator A5034293633 @default.
- W2899014944 creator A5037991629 @default.
- W2899014944 creator A5052574334 @default.
- W2899014944 creator A5087119700 @default.
- W2899014944 date "2018-11-04" @default.
- W2899014944 modified "2023-09-27" @default.
- W2899014944 title "Polo-Like Kinase 4 (PLK4) Is Overexpressed in Central Nervous System Neuroblastoma (CNS-NB)" @default.
- W2899014944 cites W1486182207 @default.
- W2899014944 cites W1496566285 @default.
- W2899014944 cites W1511277433 @default.
- W2899014944 cites W1536266814 @default.
- W2899014944 cites W1577577364 @default.
- W2899014944 cites W1893588436 @default.
- W2899014944 cites W1966020001 @default.
- W2899014944 cites W1979566241 @default.
- W2899014944 cites W1983061009 @default.
- W2899014944 cites W1987198984 @default.
- W2899014944 cites W2000302922 @default.
- W2899014944 cites W2004548769 @default.
- W2899014944 cites W2015660037 @default.
- W2899014944 cites W2027336843 @default.
- W2899014944 cites W2027748580 @default.
- W2899014944 cites W2031797360 @default.
- W2899014944 cites W2036361742 @default.
- W2899014944 cites W2038060241 @default.
- W2899014944 cites W2056753605 @default.
- W2899014944 cites W2057924308 @default.
- W2899014944 cites W2059706140 @default.
- W2899014944 cites W2068512864 @default.
- W2899014944 cites W2073571655 @default.
- W2899014944 cites W2074897052 @default.
- W2899014944 cites W2083114373 @default.
- W2899014944 cites W2095750516 @default.
- W2899014944 cites W2130703531 @default.
- W2899014944 cites W2140409715 @default.
- W2899014944 cites W2159877959 @default.
- W2899014944 cites W2160382843 @default.
- W2899014944 cites W2162563526 @default.
- W2899014944 cites W2165093450 @default.
- W2899014944 cites W2176129996 @default.
- W2899014944 cites W2194332352 @default.
- W2899014944 cites W2286322195 @default.
- W2899014944 cites W2324431883 @default.
- W2899014944 cites W2328352462 @default.
- W2899014944 cites W2343410677 @default.
- W2899014944 cites W2366536035 @default.
- W2899014944 cites W2467305440 @default.
- W2899014944 cites W2526188224 @default.
- W2899014944 cites W2555663947 @default.
- W2899014944 cites W2582256818 @default.
- W2899014944 cites W2606435996 @default.
- W2899014944 cites W2613665458 @default.
- W2899014944 cites W2618204578 @default.
- W2899014944 cites W2701283879 @default.
- W2899014944 cites W2739792246 @default.
- W2899014944 cites W2760655823 @default.
- W2899014944 cites W2761275051 @default.
- W2899014944 cites W2768793422 @default.
- W2899014944 cites W2772287653 @default.
- W2899014944 cites W2781466531 @default.
- W2899014944 cites W2783351339 @default.
- W2899014944 cites W2787299637 @default.
- W2899014944 cites W2789656425 @default.
- W2899014944 cites W2794019434 @default.
- W2899014944 cites W2800591983 @default.
- W2899014944 cites W2804201715 @default.
- W2899014944 cites W2830206124 @default.
- W2899014944 cites W2883340872 @default.
- W2899014944 cites W2886464557 @default.
- W2899014944 cites W2887335753 @default.
- W2899014944 cites W2891256228 @default.
- W2899014944 cites W4211031423 @default.
- W2899014944 cites W4211147182 @default.
- W2899014944 cites W4244596099 @default.
- W2899014944 cites W4296289652 @default.
- W2899014944 doi "https://doi.org/10.3390/bioengineering5040096" @default.
- W2899014944 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6315664" @default.
- W2899014944 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30400339" @default.
- W2899014944 hasPublicationYear "2018" @default.
- W2899014944 type Work @default.
- W2899014944 sameAs 2899014944 @default.
- W2899014944 citedByCount "19" @default.
- W2899014944 countsByYear W28990149442018 @default.
- W2899014944 countsByYear W28990149442019 @default.
- W2899014944 countsByYear W28990149442020 @default.
- W2899014944 countsByYear W28990149442021 @default.
- W2899014944 countsByYear W28990149442022 @default.
- W2899014944 countsByYear W28990149442023 @default.
- W2899014944 crossrefType "journal-article" @default.
- W2899014944 hasAuthorship W2899014944A5016473426 @default.
- W2899014944 hasAuthorship W2899014944A5023971218 @default.
- W2899014944 hasAuthorship W2899014944A5027060903 @default.