FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899016727> ?p ?o ?g. }

• W2899016727 endingPage "89" @default.
• W2899016727 startingPage "82" @default.
• W2899016727 abstract "Porcine reproductive and respiratory syndrome virus (PRRSV) infection which caused severe reproductive failure and respiratory disorders in swine is accompanied with severe nervous symptoms. Our previous studies demonstrated that microglia, the resident innate immune cells in central nervous system (CNS), could support PRRSV infection and replication in vitro. And PRRSV infection led to the increased expressions of large amounts of proinflammatory cytokines and chemokines which contributed to neuropathogenesis of PRRSV. Interleukin-1β (IL-1β) is one of the increased proinflammatory cytokines, which possesses diverse functions in immune response upon virus infection, including activation of innate immune and modulation of adaptive immune responses. Importantly, considerable evidences indicated that 1L-1β is involved in neuronal injury. Here, we demonstrated that PRRSV infection up-regulated IL-1β expression at both the mRNA and protein levels in microglia in a dose-dependent manner. Myeloid differentiation primary response gene 88 (MyD88), extracellular signal-regulated kinase1/2 (ERK) and activator protein 1 (AP-1) were involved in PRRSV induced IL-1β production in microglia. Moreover, NOD-like receptor protein 3 (NLRP3) inflammasome is activated by PRRSV in microglia, which is required for IL-1β secretion. Taken together, our data indicated that PRRSV infection could induce IL-1β up-regulation, which was likely mediated by MyD88/ERK/AP-1 and NLRP3 inflammasome. These findings will provide new insights into the molecular mechanisms of IL-1β production and some implications for neuropathogenesis of PRRSV." @default.
• W2899016727 created "2018-11-09" @default.
• W2899016727 creator A5007641506 @default.
• W2899016727 creator A5011083752 @default.
• W2899016727 creator A5020052645 @default.
• W2899016727 creator A5022684433 @default.
• W2899016727 creator A5034679877 @default.
• W2899016727 creator A5064115375 @default.
• W2899016727 creator A5064455149 @default.
• W2899016727 creator A5077224438 @default.
• W2899016727 creator A5088730165 @default.
• W2899016727 date "2018-12-01" @default.
• W2899016727 modified "2023-10-18" @default.
• W2899016727 title "Porcine reproductive and respiratory syndrome virus induces interleukin-1β through MyD88/ERK/AP-1 and NLRP3 inflammasome in microglia" @default.
• W2899016727 cites W1963739393 @default.
• W2899016727 cites W1979035564 @default.
• W2899016727 cites W1992841021 @default.
• W2899016727 cites W1993728991 @default.
• W2899016727 cites W2001420087 @default.
• W2899016727 cites W2004349171 @default.
• W2899016727 cites W2005470401 @default.
• W2899016727 cites W2008944418 @default.
• W2899016727 cites W2014259367 @default.
• W2899016727 cites W2018834289 @default.
• W2899016727 cites W2019073610 @default.
• W2899016727 cites W2030912283 @default.
• W2899016727 cites W2040654802 @default.
• W2899016727 cites W2040723870 @default.
• W2899016727 cites W2042196311 @default.
• W2899016727 cites W2047817815 @default.
• W2899016727 cites W2049526168 @default.
• W2899016727 cites W2067622131 @default.
• W2899016727 cites W2069727032 @default.
• W2899016727 cites W2070296114 @default.
• W2899016727 cites W2083124439 @default.
• W2899016727 cites W2085369607 @default.
• W2899016727 cites W2114570899 @default.
• W2899016727 cites W2133109371 @default.
• W2899016727 cites W2138766005 @default.
• W2899016727 cites W2155177346 @default.
• W2899016727 cites W2157650174 @default.
• W2899016727 cites W2163617266 @default.
• W2899016727 cites W2174186223 @default.
• W2899016727 cites W2405748887 @default.
• W2899016727 cites W2583070614 @default.
• W2899016727 cites W2608041844 @default.
• W2899016727 cites W2781555529 @default.
• W2899016727 doi "https://doi.org/10.1016/j.vetmic.2018.10.030" @default.
• W2899016727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30473357" @default.
• W2899016727 hasPublicationYear "2018" @default.
• W2899016727 type Work @default.
• W2899016727 sameAs 2899016727 @default.
• W2899016727 citedByCount "20" @default.
• W2899016727 countsByYear W28990167272019 @default.
• W2899016727 countsByYear W28990167272020 @default.
• W2899016727 countsByYear W28990167272021 @default.
• W2899016727 countsByYear W28990167272022 @default.
• W2899016727 countsByYear W28990167272023 @default.
• W2899016727 crossrefType "journal-article" @default.
• W2899016727 hasAuthorship W2899016727A5007641506 @default.
• W2899016727 hasAuthorship W2899016727A5011083752 @default.
• W2899016727 hasAuthorship W2899016727A5020052645 @default.
• W2899016727 hasAuthorship W2899016727A5022684433 @default.
• W2899016727 hasAuthorship W2899016727A5034679877 @default.
• W2899016727 hasAuthorship W2899016727A5064115375 @default.
• W2899016727 hasAuthorship W2899016727A5064455149 @default.
• W2899016727 hasAuthorship W2899016727A5077224438 @default.
• W2899016727 hasAuthorship W2899016727A5088730165 @default.
• W2899016727 hasConcept C13373296 @default.
• W2899016727 hasConcept C136449434 @default.
• W2899016727 hasConcept C164027704 @default.
• W2899016727 hasConcept C193419808 @default.
• W2899016727 hasConcept C203014093 @default.
• W2899016727 hasConcept C2522874641 @default.
• W2899016727 hasConcept C2776914184 @default.
• W2899016727 hasConcept C2777209026 @default.
• W2899016727 hasConcept C2779819720 @default.
• W2899016727 hasConcept C2779830541 @default.
• W2899016727 hasConcept C86803240 @default.
• W2899016727 hasConcept C8891405 @default.
• W2899016727 hasConceptScore W2899016727C13373296 @default.
• W2899016727 hasConceptScore W2899016727C136449434 @default.
• W2899016727 hasConceptScore W2899016727C164027704 @default.
• W2899016727 hasConceptScore W2899016727C193419808 @default.
• W2899016727 hasConceptScore W2899016727C203014093 @default.
• W2899016727 hasConceptScore W2899016727C2522874641 @default.
• W2899016727 hasConceptScore W2899016727C2776914184 @default.
• W2899016727 hasConceptScore W2899016727C2777209026 @default.
• W2899016727 hasConceptScore W2899016727C2779819720 @default.
• W2899016727 hasConceptScore W2899016727C2779830541 @default.
• W2899016727 hasConceptScore W2899016727C86803240 @default.
• W2899016727 hasConceptScore W2899016727C8891405 @default.
• W2899016727 hasLocation W28990167271 @default.
• W2899016727 hasLocation W28990167272 @default.
• W2899016727 hasOpenAccess W2899016727 @default.
• W2899016727 hasPrimaryLocation W28990167271 @default.
• W2899016727 hasRelatedWork W1557621914 @default.
• W2899016727 hasRelatedWork W2090637482 @default.

• next