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- W2899043265 endingPage "456" @default.
- W2899043265 startingPage "447" @default.
- W2899043265 abstract "Insulin resistance is associated with numerous metabolic disorders, such as obesity and type II diabetes, that currently plague our society. Although insulin normally promotes anabolic metabolism in the liver by increasing glucose consumption and lipid synthesis, insulin-resistant individuals fail to inhibit hepatic glucose production and paradoxically have increased liver lipid synthesis, leading to hyperglycemia and hypertriglyceridemia. Here, we detail the intrahepatic and extrahepatic pathways mediating insulin's control of glucose and lipid metabolism. We propose that the interplay between both of these pathways controls insulin signaling and that mis-regulation between the 2 results in the paradoxic effects seen in the insulin-resistant liver instead of the commonly proposed deficiencies in particular branches of only the direct hepatic pathway." @default.
- W2899043265 created "2018-11-09" @default.
- W2899043265 creator A5031048434 @default.
- W2899043265 creator A5043009124 @default.
- W2899043265 date "2019-01-01" @default.
- W2899043265 modified "2023-10-14" @default.
- W2899043265 title "Resolving the Paradox of Hepatic Insulin Resistance" @default.
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