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- W2899043391 endingPage "501" @default.
- W2899043391 startingPage "487" @default.
- W2899043391 abstract "Rapid and efficient digestion and absorption of dietary triglycerides and other lipids by the intestine, the packaging of those lipids into lipoprotein chylomicron (CM) particles, and their secretion via the lymphatic duct into the blood circulation are essential in maintaining whole-body lipid and energy homeostasis. Biosynthesis and assembly of CMs in enterocytes is a complex multistep process that is subject to regulation by intracellular signaling pathways as well as by hormones, nutrients, and neural factors extrinsic to the enterocyte. Dysregulation of this process has implications for health and disease, contributing to dyslipidemia and a potentially increased risk of atherosclerotic cardiovascular disease. There is increasing recognition that, besides intracellular regulation of CM assembly and secretion, regulation of postassembly pathways also plays important roles in CM secretion. This review examines recent advances in our understanding of the regulation of CM secretion in relation to mobilization of intestinal lipid stores, drawing particular attention to post-assembly regulatory mechanisms, including intracellular trafficking of triglycerides in enterocytes, CM mobilization from the lamina propria, and regulated transport of CM by intestinal lymphatics." @default.
- W2899043391 created "2018-11-09" @default.
- W2899043391 creator A5024729525 @default.
- W2899043391 creator A5034414826 @default.
- W2899043391 creator A5071484843 @default.
- W2899043391 date "2019-01-01" @default.
- W2899043391 modified "2023-10-13" @default.
- W2899043391 title "Regulation of Chylomicron Secretion: Focus on Post-Assembly Mechanisms" @default.
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