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- W2899046550 endingPage "e201800171" @default.
- W2899046550 startingPage "e201800171" @default.
- W2899046550 abstract "Deregulated activity of LArge Tumor Suppressor (LATS) tumor suppressors has broad implications on cellular and tissue homeostasis. We examined the consequences of down-regulation of either LATS1 or LATS2 in breast cancer. Consistent with their proposed tumor suppressive roles, expression of both paralogs was significantly down-regulated in human breast cancer, and loss of either paralog accelerated mammary tumorigenesis in mice. However, each paralog had a distinct impact on breast cancer. Thus, LATS2 depletion in luminal B tumors resulted in metabolic rewiring, with increased glycolysis and reduced peroxisome proliferator-activated receptor γ (PPARγ) signaling. Furthermore, pharmacological activation of PPARγ elicited LATS2-dependent death in luminal B-derived cells. In contrast, LATS1 depletion augmented cancer cell plasticity, skewing luminal B tumors towards increased expression of basal-like features, in association with increased resistance to hormone therapy. Hence, these two closely related paralogs play distinct roles in protection against breast cancer; tumors with reduced expression of either LATS1 or LATS2 may rewire signaling networks differently and thus respond differently to anticancer treatments." @default.
- W2899046550 created "2018-11-09" @default.
- W2899046550 creator A5000407487 @default.
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- W2899046550 creator A5081382383 @default.
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- W2899046550 creator A5091192198 @default.
- W2899046550 date "2018-10-01" @default.
- W2899046550 modified "2023-10-18" @default.
- W2899046550 title "LATS1 and LATS2 suppress breast cancer progression by maintaining cell identity and metabolic state" @default.
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