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- W2899052433 abstract "Arginine vasopressin (VP) has been implicated in a number of neuropsychiatric disorders with an emphasis on situations where stress increased the severity of the disorder. Based on this hypothesized role for VP in neuropsychiatric disorders, much research is currently being undertaken in humans and animals to test VP as a target for treatment of a number of these disorders including alcohol abuse. To provide a summary of the literature regarding the role of VP in alcohol- and stress-related behaviors including the use of drugs that target VP in clinical trials. Changes in various components of the VP system occur with alcohol and stress. Manipulating VP or its receptors can alter alcohol- and stress-related behaviors including tolerance to alcohol, alcohol drinking, and anxiety-like behavior. Finally, the hypothalamic–pituitary–adrenal axis response to alcohol is also altered by manipulating the VP system. However, clinical trials of VP antagonists have had mixed results. A review of VP’s involvement in alcohol’s actions demonstrates that there is much to be learned about brain regions involved in VP-mediated effects on behavior. Thus, future work should focus on elucidating relevant brain regions. By using previous knowledge of the actions of VP and determining the brain regions and/or systems involved in its different behavioral effects, it may be possible to identify a specific receptor subtype target, drug treatment combination, or specific clinical contexts that may point toward a more successful treatment." @default.
- W2899052433 created "2018-11-09" @default.
- W2899052433 creator A5026416051 @default.
- W2899052433 creator A5037448315 @default.
- W2899052433 creator A5047283665 @default.
- W2899052433 creator A5067192678 @default.
- W2899052433 date "2018-11-03" @default.
- W2899052433 modified "2023-10-18" @default.
- W2899052433 title "Vasopressin and alcohol: a multifaceted relationship" @default.
- W2899052433 cites W1488549686 @default.
- W2899052433 cites W1522686917 @default.
- W2899052433 cites W1524018505 @default.
- W2899052433 cites W1623788409 @default.
- W2899052433 cites W1654041858 @default.
- W2899052433 cites W1668201868 @default.
- W2899052433 cites W1737076464 @default.
- W2899052433 cites W1970083794 @default.
- W2899052433 cites W1972389227 @default.
- W2899052433 cites W1973759337 @default.
- W2899052433 cites W1975312360 @default.
- W2899052433 cites W1975731777 @default.
- W2899052433 cites W1979024772 @default.
- W2899052433 cites W1981233428 @default.
- W2899052433 cites W1982375224 @default.
- W2899052433 cites W1982672191 @default.
- W2899052433 cites W1984058716 @default.
- W2899052433 cites W1984540432 @default.
- W2899052433 cites W1984791983 @default.
- W2899052433 cites W1987103116 @default.
- W2899052433 cites W1987614284 @default.
- W2899052433 cites W1987660182 @default.
- W2899052433 cites W1989699697 @default.
- W2899052433 cites W1989713715 @default.
- W2899052433 cites W1989992663 @default.
- W2899052433 cites W1991485877 @default.
- W2899052433 cites W1992729034 @default.
- W2899052433 cites W1995071454 @default.
- W2899052433 cites W1995081746 @default.
- W2899052433 cites W1996622763 @default.
- W2899052433 cites W1998008498 @default.
- W2899052433 cites W1998241855 @default.
- W2899052433 cites W1998872047 @default.
- W2899052433 cites W1999127613 @default.
- W2899052433 cites W2001920036 @default.
- W2899052433 cites W2003547326 @default.
- W2899052433 cites W2008027539 @default.
- W2899052433 cites W2008597980 @default.
- W2899052433 cites W2008854333 @default.
- W2899052433 cites W2010711792 @default.
- W2899052433 cites W2015564268 @default.
- W2899052433 cites W2019776836 @default.
- W2899052433 cites W2019990245 @default.
- W2899052433 cites W2020140739 @default.
- W2899052433 cites W2020533417 @default.
- W2899052433 cites W2022227059 @default.
- W2899052433 cites W2022789146 @default.
- W2899052433 cites W2024575890 @default.
- W2899052433 cites W2027741858 @default.
- W2899052433 cites W2027848195 @default.
- W2899052433 cites W2027893324 @default.
- W2899052433 cites W2028527647 @default.
- W2899052433 cites W2029228951 @default.
- W2899052433 cites W2033288100 @default.
- W2899052433 cites W2033500251 @default.
- W2899052433 cites W2034826919 @default.
- W2899052433 cites W2035731977 @default.
- W2899052433 cites W2036871700 @default.
- W2899052433 cites W2037725254 @default.
- W2899052433 cites W2037880568 @default.
- W2899052433 cites W2038065778 @default.
- W2899052433 cites W2042370434 @default.
- W2899052433 cites W2043034364 @default.
- W2899052433 cites W2043050293 @default.
- W2899052433 cites W2043337264 @default.
- W2899052433 cites W2043621158 @default.
- W2899052433 cites W2045497581 @default.
- W2899052433 cites W2045659750 @default.
- W2899052433 cites W2047532712 @default.
- W2899052433 cites W2048162947 @default.
- W2899052433 cites W2049223399 @default.
- W2899052433 cites W2051283142 @default.
- W2899052433 cites W2051433145 @default.
- W2899052433 cites W2051898444 @default.
- W2899052433 cites W2054150485 @default.
- W2899052433 cites W2057462579 @default.
- W2899052433 cites W2059544240 @default.
- W2899052433 cites W2060309994 @default.
- W2899052433 cites W2061265867 @default.
- W2899052433 cites W2061489766 @default.
- W2899052433 cites W2063071532 @default.
- W2899052433 cites W2063647589 @default.
- W2899052433 cites W2063778031 @default.
- W2899052433 cites W2066531541 @default.
- W2899052433 cites W2067045600 @default.
- W2899052433 cites W2067536811 @default.
- W2899052433 cites W2069300470 @default.
- W2899052433 cites W2070279391 @default.
- W2899052433 cites W2070697019 @default.