Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899052968> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2899052968 endingPage "118" @default.
- W2899052968 startingPage "109" @default.
- W2899052968 abstract "The aim of this study is to develop validated methods for the extraction and quantification of antimalarial triterpene esters from Keetia leucantha and from plasma samples. These compounds, showing in vitro and in vivo antiplasmodial activities, were optimally extracted from Keetia leucantha twigs using ultrasounds with dichloromethane and from plasma using protein precipitation with acetonitrile. We then developed and validated HPLC-UV quantification methods, which proved to be selective, accurate, linear, true and precise, both in plant and plasma samples for the eight triterpenic esters in mixture. Based on the total error concept as decision criteria, the validated dosage ranges of the triterpene esters mixture were set between 14.68 and 73.37 μg/mL in plants and 15.90 and 106.01 μg/mL in plasma injected solutions, corresponding to 7.95 and 53.01 μg/mL in plasma. These reliable methods were used to determine effectively triterpene esters content in collected samples, that seems highly variable in plant extracts, and will be helpful to further investigate pharmacokinetics parameters of these interesting bioactive compounds." @default.
- W2899052968 created "2018-11-09" @default.
- W2899052968 creator A5005100938 @default.
- W2899052968 creator A5008678082 @default.
- W2899052968 creator A5008959529 @default.
- W2899052968 creator A5016295209 @default.
- W2899052968 creator A5017858936 @default.
- W2899052968 creator A5056774766 @default.
- W2899052968 creator A5089809679 @default.
- W2899052968 date "2019-01-01" @default.
- W2899052968 modified "2023-10-17" @default.
- W2899052968 title "Optimization and validation of extraction and quantification methods of antimalarial triterpenic esters in Keetia leucantha plant and plasma" @default.
- W2899052968 cites W1532220449 @default.
- W2899052968 cites W181161799 @default.
- W2899052968 cites W1969069716 @default.
- W2899052968 cites W1974654507 @default.
- W2899052968 cites W2027953708 @default.
- W2899052968 cites W2037435629 @default.
- W2899052968 cites W2038887886 @default.
- W2899052968 cites W2052772167 @default.
- W2899052968 cites W2075441374 @default.
- W2899052968 cites W2096699003 @default.
- W2899052968 cites W2115589494 @default.
- W2899052968 cites W2121128070 @default.
- W2899052968 cites W2127885682 @default.
- W2899052968 cites W2138998035 @default.
- W2899052968 cites W2164614248 @default.
- W2899052968 cites W2167105066 @default.
- W2899052968 cites W2171102256 @default.
- W2899052968 cites W2314640825 @default.
- W2899052968 cites W2472994826 @default.
- W2899052968 cites W2556828336 @default.
- W2899052968 cites W2762085452 @default.
- W2899052968 cites W4230965759 @default.
- W2899052968 cites W43893483 @default.
- W2899052968 doi "https://doi.org/10.1016/j.jchromb.2018.11.003" @default.
- W2899052968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30448629" @default.
- W2899052968 hasPublicationYear "2019" @default.
- W2899052968 type Work @default.
- W2899052968 sameAs 2899052968 @default.
- W2899052968 citedByCount "2" @default.
- W2899052968 countsByYear W28990529682019 @default.
- W2899052968 countsByYear W28990529682023 @default.
- W2899052968 crossrefType "journal-article" @default.
- W2899052968 hasAuthorship W2899052968A5005100938 @default.
- W2899052968 hasAuthorship W2899052968A5008678082 @default.
- W2899052968 hasAuthorship W2899052968A5008959529 @default.
- W2899052968 hasAuthorship W2899052968A5016295209 @default.
- W2899052968 hasAuthorship W2899052968A5017858936 @default.
- W2899052968 hasAuthorship W2899052968A5056774766 @default.
- W2899052968 hasAuthorship W2899052968A5089809679 @default.
- W2899052968 hasConcept C142724271 @default.
- W2899052968 hasConcept C178790620 @default.
- W2899052968 hasConcept C179998833 @default.
- W2899052968 hasConcept C185592680 @default.
- W2899052968 hasConcept C204787440 @default.
- W2899052968 hasConcept C2780400988 @default.
- W2899052968 hasConcept C2780471494 @default.
- W2899052968 hasConcept C2780527577 @default.
- W2899052968 hasConcept C43617362 @default.
- W2899052968 hasConcept C4725764 @default.
- W2899052968 hasConcept C71924100 @default.
- W2899052968 hasConcept C74774607 @default.
- W2899052968 hasConceptScore W2899052968C142724271 @default.
- W2899052968 hasConceptScore W2899052968C178790620 @default.
- W2899052968 hasConceptScore W2899052968C179998833 @default.
- W2899052968 hasConceptScore W2899052968C185592680 @default.
- W2899052968 hasConceptScore W2899052968C204787440 @default.
- W2899052968 hasConceptScore W2899052968C2780400988 @default.
- W2899052968 hasConceptScore W2899052968C2780471494 @default.
- W2899052968 hasConceptScore W2899052968C2780527577 @default.
- W2899052968 hasConceptScore W2899052968C43617362 @default.
- W2899052968 hasConceptScore W2899052968C4725764 @default.
- W2899052968 hasConceptScore W2899052968C71924100 @default.
- W2899052968 hasConceptScore W2899052968C74774607 @default.
- W2899052968 hasFunder F4320321390 @default.
- W2899052968 hasLocation W28990529681 @default.
- W2899052968 hasLocation W28990529682 @default.
- W2899052968 hasOpenAccess W2899052968 @default.
- W2899052968 hasPrimaryLocation W28990529681 @default.
- W2899052968 hasRelatedWork W1588095382 @default.
- W2899052968 hasRelatedWork W1974970751 @default.
- W2899052968 hasRelatedWork W1980331802 @default.
- W2899052968 hasRelatedWork W2018671480 @default.
- W2899052968 hasRelatedWork W2058639927 @default.
- W2899052968 hasRelatedWork W2063013405 @default.
- W2899052968 hasRelatedWork W2129872829 @default.
- W2899052968 hasRelatedWork W2376531500 @default.
- W2899052968 hasRelatedWork W92794636 @default.
- W2899052968 hasRelatedWork W2524959782 @default.
- W2899052968 hasVolume "1104" @default.
- W2899052968 isParatext "false" @default.
- W2899052968 isRetracted "false" @default.
- W2899052968 magId "2899052968" @default.
- W2899052968 workType "article" @default.