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- W2899059923 abstract "Lambda interferons (IFNλs, type III IFNs or interleukins-28/29) were described fifteen years ago as novel cytokines sharing structural and functional homology with IL-10 and type I IFNs, respectively. IFNλs engage a unique receptor complex comprising IFNLR1 and IL10R2, nevertheless they share signaling cascade and many functions with type I IFNs, questioning their possible non-redundant roles and overall biological importance. Here, we review the latest evidence establishing the primacy of IFNλs in front line protection at anatomical barriers, mediating antiviral immunity before type I IFNs. We also discuss their emerging role in regulating inflammation and limiting host damage, a major difference to type I IFNs. IFNλs come thus to light as dual function cytokines mediating antiviral immunity and damage control." @default.
- W2899059923 created "2018-11-09" @default.
- W2899059923 creator A5008592883 @default.
- W2899059923 creator A5050715964 @default.
- W2899059923 creator A5071817729 @default.
- W2899059923 date "2019-02-01" @default.
- W2899059923 modified "2023-10-11" @default.
- W2899059923 title "Lambda interferons come to light: dual function cytokines mediating antiviral immunity and damage control" @default.
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- W2899059923 doi "https://doi.org/10.1016/j.coi.2018.10.007" @default.
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- W2899059923 hasPublicationYear "2019" @default.
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