FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899068409> ?p ?o ?g. }

• W2899068409 endingPage "389" @default.
• W2899068409 startingPage "379" @default.
• W2899068409 abstract "OBJECTIVES To determine the frequency of subtherapeutic exposure to intravenously administered β-lactam antibiotics in a cohort of cystic fibrosis (CF) patients who were treated for a pulmonary exacerbation, and its impact on pulmonary function. METHODS Nineteen CF patients between the ages of 5 and 21 years treated at Children's National Health System for a pulmonary exacerbation were followed between March 2015 and August 2016 in a prospective, longitudinal study. Pharmacokinetic modeling and minimum inhibitory concentrations (MICs) of the involved pathogens were used to determine therapeutic or subtherapeutic β-lactam antibiotic exposure based on the time the antibiotic concentration was above the MIC. Clinical outcomes were measured by spirometry values. RESULTS The 19 participants were treated with a total of 29 courses of antibiotics. The most common β-lactam antibiotics used in a treatment course were ceftazidime (62%) and meropenem (45%). There was no difference in age, CF genotype, or creatinine clearance between the 9 participants (47%) who reached therapeutic concentrations versus the 10 (53%) who did not. Those who achieved sufficiently high antibiotic exposure had more significant improvement of their pulmonary function tests. CONCLUSIONS We found that sufficient antibiotic exposure during treatment of CF pulmonary exacerbations was associated with improved pulmonary function. Moreover, it was impossible to predict, solely from the dosing regimen used, which patients were going to reach therapeutic β-lactam antibiotic serum concentrations. This suggests that CF patients may benefit from closer monitoring of their β-lactam exposure and bacterial MIC for optimal clinical outcomes." @default.
• W2899068409 created "2018-11-09" @default.
• W2899068409 creator A5002462952 @default.
• W2899068409 creator A5003492597 @default.
• W2899068409 creator A5034957799 @default.
• W2899068409 creator A5039413727 @default.
• W2899068409 creator A5039746362 @default.
• W2899068409 creator A5053154553 @default.
• W2899068409 creator A5055773244 @default.
• W2899068409 creator A5057776173 @default.
• W2899068409 creator A5058691830 @default.
• W2899068409 creator A5079176362 @default.
• W2899068409 date "2018-09-01" @default.
• W2899068409 modified "2023-10-14" @default.
• W2899068409 title "Relationship of Pulmonary Outcomes, Microbiology, and Serum Antibiotic Concentrations in Cystic Fibrosis Patients" @default.
• W2899068409 cites W1802199068 @default.
• W2899068409 cites W1965165402 @default.
• W2899068409 cites W1967571838 @default.
• W2899068409 cites W1977053518 @default.
• W2899068409 cites W1992444327 @default.
• W2899068409 cites W1996565956 @default.
• W2899068409 cites W1997569777 @default.
• W2899068409 cites W2015039953 @default.
• W2899068409 cites W2021319218 @default.
• W2899068409 cites W2023174165 @default.
• W2899068409 cites W2031470977 @default.
• W2899068409 cites W2046526279 @default.
• W2899068409 cites W2055741709 @default.
• W2899068409 cites W2071034664 @default.
• W2899068409 cites W2072098181 @default.
• W2899068409 cites W2079691262 @default.
• W2899068409 cites W2093274439 @default.
• W2899068409 cites W2096779618 @default.
• W2899068409 cites W2099449365 @default.
• W2899068409 cites W2101273248 @default.
• W2899068409 cites W2103884572 @default.
• W2899068409 cites W2113717321 @default.
• W2899068409 cites W2121066468 @default.
• W2899068409 cites W2123305940 @default.
• W2899068409 cites W2132649447 @default.
• W2899068409 cites W2140859239 @default.
• W2899068409 cites W2146292644 @default.
• W2899068409 cites W2151281235 @default.
• W2899068409 cites W2155069031 @default.
• W2899068409 cites W2207395464 @default.
• W2899068409 cites W2333398204 @default.
• W2899068409 cites W2552167663 @default.
• W2899068409 cites W4241884576 @default.
• W2899068409 doi "https://doi.org/10.5863/1551-6776-23.5.379" @default.
• W2899068409 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6213626" @default.
• W2899068409 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30429692" @default.
• W2899068409 hasPublicationYear "2018" @default.
• W2899068409 type Work @default.
• W2899068409 sameAs 2899068409 @default.
• W2899068409 citedByCount "6" @default.
• W2899068409 countsByYear W28990684092019 @default.
• W2899068409 countsByYear W28990684092021 @default.
• W2899068409 countsByYear W28990684092022 @default.
• W2899068409 countsByYear W28990684092023 @default.
• W2899068409 crossrefType "journal-article" @default.
• W2899068409 hasAuthorship W2899068409A5002462952 @default.
• W2899068409 hasAuthorship W2899068409A5003492597 @default.
• W2899068409 hasAuthorship W2899068409A5034957799 @default.
• W2899068409 hasAuthorship W2899068409A5039413727 @default.
• W2899068409 hasAuthorship W2899068409A5039746362 @default.
• W2899068409 hasAuthorship W2899068409A5053154553 @default.
• W2899068409 hasAuthorship W2899068409A5055773244 @default.
• W2899068409 hasAuthorship W2899068409A5057776173 @default.
• W2899068409 hasAuthorship W2899068409A5058691830 @default.
• W2899068409 hasAuthorship W2899068409A5079176362 @default.
• W2899068409 hasBestOaLocation W28990684092 @default.
• W2899068409 hasConcept C126322002 @default.
• W2899068409 hasConcept C2776042228 @default.
• W2899068409 hasConcept C2776938444 @default.
• W2899068409 hasConcept C2776968632 @default.
• W2899068409 hasConcept C2777014857 @default.
• W2899068409 hasConcept C2777637488 @default.
• W2899068409 hasConcept C2779375183 @default.
• W2899068409 hasConcept C2780333948 @default.
• W2899068409 hasConcept C501593827 @default.
• W2899068409 hasConcept C523546767 @default.
• W2899068409 hasConcept C54355233 @default.
• W2899068409 hasConcept C71924100 @default.
• W2899068409 hasConcept C75603125 @default.
• W2899068409 hasConcept C86803240 @default.
• W2899068409 hasConcept C89423630 @default.
• W2899068409 hasConcept C94665300 @default.
• W2899068409 hasConceptScore W2899068409C126322002 @default.
• W2899068409 hasConceptScore W2899068409C2776042228 @default.
• W2899068409 hasConceptScore W2899068409C2776938444 @default.
• W2899068409 hasConceptScore W2899068409C2776968632 @default.
• W2899068409 hasConceptScore W2899068409C2777014857 @default.
• W2899068409 hasConceptScore W2899068409C2777637488 @default.
• W2899068409 hasConceptScore W2899068409C2779375183 @default.
• W2899068409 hasConceptScore W2899068409C2780333948 @default.
• W2899068409 hasConceptScore W2899068409C501593827 @default.
• W2899068409 hasConceptScore W2899068409C523546767 @default.
• W2899068409 hasConceptScore W2899068409C54355233 @default.

• next