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- W2899085061 abstract "Alloimmunization to red blood cells (RBCs) may result in fetal anemia prior to 20 weeks gestation. The question as to whether early commencement of antenatal treatment with high-dose intravenous immunoglobulins (IVIG) may prevent or at least delay the development of fetal anemia in the presence of alloantibodies to RBCs is highly relevant.Here we describe a patient with high-titer anti-K and two other severely affected pregnant women with a history of recurrent pregnancy loss due to high-titer anti-D or anti-D plus anti-C. Early commencement of treatment with IVIG (1 g/kg/week) resulted in prevention of intrauterine transfusion (IUT) in the former two cases, and in a significant delay of development of fetal anemia in the remaining case (26 weeks gestation).Based on our findings and of previously published cases, early initiation of treatment of severely alloimmunized women with IVIG (1 g/kg/week) could potentially improve the outcome of fetuses at risk." @default.
- W2899085061 created "2018-11-09" @default.
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- W2899085061 creator A5086899484 @default.
- W2899085061 date "2018-01-01" @default.
- W2899085061 modified "2023-10-14" @default.
- W2899085061 title "Efficacy of Antenatal Intravenous Immunoglobulin Treatment in Pregnancies at High Risk due to Alloimmunization to Red Blood Cells" @default.
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- W2899085061 doi "https://doi.org/10.1159/000490154" @default.
- W2899085061 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6288630" @default.
- W2899085061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30574060" @default.
- W2899085061 hasPublicationYear "2018" @default.
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