FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899090069> ?p ?o ?g. }

• W2899090069 endingPage "1092" @default.
• W2899090069 startingPage "1087" @default.
• W2899090069 abstract "Pneumocystis jirovecii pneumonia (PJP) is a rare but potentially fatal opportunistic infection; however, consensus varies around which conditions or medications confer a level of risk sufficient to justify antibiotic prophylaxis for PJP. We used electronic health record (EHR) data to assess the current patterns of PJP prophylaxis, PJP outcomes, and prophylaxis-related adverse events among patients with rheumatic diseases who were receiving high-risk immunosuppressant drugs.Data derive from the EHR of a large health system. We included new immunosuppressant users with diagnoses of vasculitis, myositis, or systemic lupus erythematosus. We calculated the proportion of patients who received PJP prophylaxis for each diagnosis and drug combination. We also calculated the number of PJP infections and the number of antibiotic adverse drug events (ADEs) per patient-year of exposure.We followed 316 patients for 23.2 + /- 14.2 months. Overall, 124 (39%) of patients received prophylactic antibiotics for PJP. At least 25% of patients with the highest risk conditions (e.g. vasculitis) or highest risk immunosuppressants (e.g. cyclophosphamide) did not receive PJP prophylaxis. We found no cases of PJP infection over 640 patient-years of follow up, including among those not receiving prophylaxis, and an overall incidence rate of ADEs of 2.2% per patient-year.PJP prophylaxis for patients with rheumatic conditions is inconsistent, with one quarter of patients who have high risk conditions or high risk immunosuppressants not receiving prophylaxis. However, given extremely low rates of PJP infection, but detectable ADEs to prophylactic antibiotics, our findings suggest that evidence to guide more personalized risk assessments are needed to inform PJP prophylaxis." @default.
• W2899090069 created "2018-11-09" @default.
• W2899090069 creator A5027451778 @default.
• W2899090069 creator A5037605693 @default.
• W2899090069 creator A5037692645 @default.
• W2899090069 creator A5038112278 @default.
• W2899090069 creator A5042754254 @default.
• W2899090069 creator A5044143803 @default.
• W2899090069 creator A5049006078 @default.
• W2899090069 creator A5050618420 @default.
• W2899090069 creator A5052786052 @default.
• W2899090069 creator A5067514695 @default.
• W2899090069 creator A5082959844 @default.
• W2899090069 date "2019-06-01" @default.
• W2899090069 modified "2023-10-09" @default.
• W2899090069 title "Pneumocystis jirovecii pneumonia (PJP) prophylaxis patterns among patients with rheumatic diseases receiving high-risk immunosuppressant drugs" @default.
• W2899090069 cites W153034056 @default.
• W2899090069 cites W1968696159 @default.
• W2899090069 cites W1976692122 @default.
• W2899090069 cites W2006217724 @default.
• W2899090069 cites W2059227619 @default.
• W2899090069 cites W2064364188 @default.
• W2899090069 cites W2078553534 @default.
• W2899090069 cites W2095621848 @default.
• W2899090069 cites W2103791151 @default.
• W2899090069 cites W2120185140 @default.
• W2899090069 cites W2124483143 @default.
• W2899090069 cites W2124791110 @default.
• W2899090069 cites W2129168200 @default.
• W2899090069 cites W2132048017 @default.
• W2899090069 cites W2137392619 @default.
• W2899090069 cites W2272630733 @default.
• W2899090069 cites W2317827786 @default.
• W2899090069 cites W2528297397 @default.
• W2899090069 cites W2563968543 @default.
• W2899090069 cites W2569129473 @default.
• W2899090069 cites W2607650379 @default.
• W2899090069 cites W2654839484 @default.
• W2899090069 cites W2735470854 @default.
• W2899090069 cites W2766715376 @default.
• W2899090069 cites W2792737741 @default.
• W2899090069 cites W2811004238 @default.
• W2899090069 cites W81624332 @default.
• W2899090069 doi "https://doi.org/10.1016/j.semarthrit.2018.10.018" @default.
• W2899090069 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6499720" @default.
• W2899090069 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30449650" @default.
• W2899090069 hasPublicationYear "2019" @default.
• W2899090069 type Work @default.
• W2899090069 sameAs 2899090069 @default.
• W2899090069 citedByCount "34" @default.
• W2899090069 countsByYear W28990900692019 @default.
• W2899090069 countsByYear W28990900692020 @default.
• W2899090069 countsByYear W28990900692021 @default.
• W2899090069 countsByYear W28990900692022 @default.
• W2899090069 countsByYear W28990900692023 @default.
• W2899090069 crossrefType "journal-article" @default.
• W2899090069 hasAuthorship W2899090069A5027451778 @default.
• W2899090069 hasAuthorship W2899090069A5037605693 @default.
• W2899090069 hasAuthorship W2899090069A5037692645 @default.
• W2899090069 hasAuthorship W2899090069A5038112278 @default.
• W2899090069 hasAuthorship W2899090069A5042754254 @default.
• W2899090069 hasAuthorship W2899090069A5044143803 @default.
• W2899090069 hasAuthorship W2899090069A5049006078 @default.
• W2899090069 hasAuthorship W2899090069A5050618420 @default.
• W2899090069 hasAuthorship W2899090069A5052786052 @default.
• W2899090069 hasAuthorship W2899090069A5067514695 @default.
• W2899090069 hasAuthorship W2899090069A5082959844 @default.
• W2899090069 hasBestOaLocation W28990900692 @default.
• W2899090069 hasConcept C120665830 @default.
• W2899090069 hasConcept C121332964 @default.
• W2899090069 hasConcept C126322002 @default.
• W2899090069 hasConcept C197934379 @default.
• W2899090069 hasConcept C2777914695 @default.
• W2899090069 hasConcept C2778602436 @default.
• W2899090069 hasConcept C2781232998 @default.
• W2899090069 hasConcept C501593827 @default.
• W2899090069 hasConcept C61511704 @default.
• W2899090069 hasConcept C71924100 @default.
• W2899090069 hasConcept C86803240 @default.
• W2899090069 hasConcept C89423630 @default.
• W2899090069 hasConceptScore W2899090069C120665830 @default.
• W2899090069 hasConceptScore W2899090069C121332964 @default.
• W2899090069 hasConceptScore W2899090069C126322002 @default.
• W2899090069 hasConceptScore W2899090069C197934379 @default.
• W2899090069 hasConceptScore W2899090069C2777914695 @default.
• W2899090069 hasConceptScore W2899090069C2778602436 @default.
• W2899090069 hasConceptScore W2899090069C2781232998 @default.
• W2899090069 hasConceptScore W2899090069C501593827 @default.
• W2899090069 hasConceptScore W2899090069C61511704 @default.
• W2899090069 hasConceptScore W2899090069C71924100 @default.
• W2899090069 hasConceptScore W2899090069C86803240 @default.
• W2899090069 hasConceptScore W2899090069C89423630 @default.
• W2899090069 hasIssue "6" @default.
• W2899090069 hasLocation W28990900691 @default.
• W2899090069 hasLocation W28990900692 @default.
• W2899090069 hasLocation W28990900693 @default.
• W2899090069 hasLocation W28990900694 @default.
• W2899090069 hasOpenAccess W2899090069 @default.

• next