FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899100296> ?p ?o ?g. }

• W2899100296 endingPage "627" @default.
• W2899100296 startingPage "619" @default.
• W2899100296 abstract "Polysaccharides comprise the major bioactive components in Momordica charantia L. We here synthesized and characterized a novel M. charantia polysaccharide‑chromium (III) complex (MCPIIaC) and assessed its anti-diabetic effects in mice with streptozotocin (STZ)-induced diabetes mellitus (DM) and its mechanism underlying hypoglycemia. MCPIIaC is a novel polysaccharide‑chromium (III) complex containing 14.68% elemental chromium. A Fourier transform infrared (FTIR) spectrogram experiment showed that the chromium ions are linked to the polysaccharide's hydroxyl groups. Combined circular dichroism (CD) and atomic force microscopy (AFM) analyses indicated that after linking with chromium ions, the flexibility of the three-dimensional structure of the polysaccharide increased. After the treatment of MCPIIaC for four weeks, the mice with STZ-induced DM exhibited significantly lower fasting blood glucose levels and body weight, whereas higher insulin levels and antioxidant enzyme activity than in the diabetic group. Optimal effects were obtained with a dosage of 30 mg MCPIIaC/kg body weight. Histological analysis indicated that MCPIIaC alleviated the oxidative tissue damage in STZ-lesioned mice. An acute toxicity experiment indicated that MCPIIaC was safe at a dose of 1500 mg/kg. These results suggest that MCPIIaC might be an excellent candidate hypoglycemic agent for the prevention of diabetes." @default.
• W2899100296 created "2018-11-09" @default.
• W2899100296 creator A5003260737 @default.
• W2899100296 creator A5020926070 @default.
• W2899100296 creator A5050505087 @default.
• W2899100296 creator A5074734978 @default.
• W2899100296 date "2019-02-01" @default.
• W2899100296 modified "2023-09-30" @default.
• W2899100296 title "Preparation of a Momordica charantia L. polysaccharide‑chromium (III) complex and its anti-hyperglycemic activity in mice with streptozotocin-induced diabetes" @default.
• W2899100296 cites W1224486700 @default.
• W2899100296 cites W1966821310 @default.
• W2899100296 cites W1967380963 @default.
• W2899100296 cites W1968834637 @default.
• W2899100296 cites W1976904942 @default.
• W2899100296 cites W1982559741 @default.
• W2899100296 cites W1988806841 @default.
• W2899100296 cites W1999652145 @default.
• W2899100296 cites W2006366211 @default.
• W2899100296 cites W2024583092 @default.
• W2899100296 cites W2030026837 @default.
• W2899100296 cites W2036227669 @default.
• W2899100296 cites W2040157836 @default.
• W2899100296 cites W2049210029 @default.
• W2899100296 cites W2052840029 @default.
• W2899100296 cites W2053430176 @default.
• W2899100296 cites W2059739241 @default.
• W2899100296 cites W2070885153 @default.
• W2899100296 cites W2086082646 @default.
• W2899100296 cites W2118465930 @default.
• W2899100296 cites W2135678446 @default.
• W2899100296 cites W2140304913 @default.
• W2899100296 cites W2143506710 @default.
• W2899100296 cites W2151716122 @default.
• W2899100296 cites W2340042701 @default.
• W2899100296 cites W2404356588 @default.
• W2899100296 cites W2409583355 @default.
• W2899100296 cites W2461462491 @default.
• W2899100296 cites W2574107018 @default.
• W2899100296 cites W2780285979 @default.
• W2899100296 cites W2796963507 @default.
• W2899100296 cites W2802059847 @default.
• W2899100296 cites W2802116732 @default.
• W2899100296 cites W4293247451 @default.
• W2899100296 doi "https://doi.org/10.1016/j.ijbiomac.2018.10.200" @default.
• W2899100296 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30391593" @default.
• W2899100296 hasPublicationYear "2019" @default.
• W2899100296 type Work @default.
• W2899100296 sameAs 2899100296 @default.
• W2899100296 citedByCount "36" @default.
• W2899100296 countsByYear W28991002962019 @default.
• W2899100296 countsByYear W28991002962020 @default.
• W2899100296 countsByYear W28991002962021 @default.
• W2899100296 countsByYear W28991002962022 @default.
• W2899100296 countsByYear W28991002962023 @default.
• W2899100296 crossrefType "journal-article" @default.
• W2899100296 hasAuthorship W2899100296A5003260737 @default.
• W2899100296 hasAuthorship W2899100296A5020926070 @default.
• W2899100296 hasAuthorship W2899100296A5050505087 @default.
• W2899100296 hasAuthorship W2899100296A5074734978 @default.
• W2899100296 hasConcept C100817775 @default.
• W2899100296 hasConcept C126322002 @default.
• W2899100296 hasConcept C134018914 @default.
• W2899100296 hasConcept C178790620 @default.
• W2899100296 hasConcept C185592680 @default.
• W2899100296 hasConcept C2778004101 @default.
• W2899100296 hasConcept C2778686829 @default.
• W2899100296 hasConcept C2779280383 @default.
• W2899100296 hasConcept C2779306644 @default.
• W2899100296 hasConcept C511782168 @default.
• W2899100296 hasConcept C55493867 @default.
• W2899100296 hasConcept C555293320 @default.
• W2899100296 hasConcept C556039675 @default.
• W2899100296 hasConcept C71924100 @default.
• W2899100296 hasConcept C98274493 @default.
• W2899100296 hasConceptScore W2899100296C100817775 @default.
• W2899100296 hasConceptScore W2899100296C126322002 @default.
• W2899100296 hasConceptScore W2899100296C134018914 @default.
• W2899100296 hasConceptScore W2899100296C178790620 @default.
• W2899100296 hasConceptScore W2899100296C185592680 @default.
• W2899100296 hasConceptScore W2899100296C2778004101 @default.
• W2899100296 hasConceptScore W2899100296C2778686829 @default.
• W2899100296 hasConceptScore W2899100296C2779280383 @default.
• W2899100296 hasConceptScore W2899100296C2779306644 @default.
• W2899100296 hasConceptScore W2899100296C511782168 @default.
• W2899100296 hasConceptScore W2899100296C55493867 @default.
• W2899100296 hasConceptScore W2899100296C555293320 @default.
• W2899100296 hasConceptScore W2899100296C556039675 @default.
• W2899100296 hasConceptScore W2899100296C71924100 @default.
• W2899100296 hasConceptScore W2899100296C98274493 @default.
• W2899100296 hasFunder F4320321001 @default.
• W2899100296 hasLocation W28991002961 @default.
• W2899100296 hasLocation W28991002962 @default.
• W2899100296 hasOpenAccess W2899100296 @default.
• W2899100296 hasPrimaryLocation W28991002961 @default.
• W2899100296 hasRelatedWork W1983641721 @default.
• W2899100296 hasRelatedWork W1995071802 @default.
• W2899100296 hasRelatedWork W2003485540 @default.
• W2899100296 hasRelatedWork W2011709829 @default.

• next