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- W2899100615 abstract "Mass spectrometry (MS) has become one of the most important analytical toolsemployed in the analysis of pharmaceuticals. This can most likely be attributedto the availability of new instrumentation and ionization techniques that can beused to help solve difficult bioanalytical problems associated with this field (18). Perhaps the best illustration of this occurrence is the development of electrospray (ESI) and related atmospheric-pressure ionization (API) techniques, ionspray (nebulizer-assisted API), turbo ionspray (thermally assisted API), andatmospheric pressure chemical ionization (APCI; nebulization coupled with corona discharge), for use in drug disposition studies. The terms ESI and ionspraytend to be used interchangeably in the literature. For the purpose of this review,the term API will be used to describe both ESI and ionspray. In recent yearsthere has been an unprecedented explosion in the use of instrumentation dedicatedto API/MS (4,6,8-14). API-based ionization techniques have now become themethod of choice for the analysis of pharmaceuticals and their metabolites. Thishas made thermospray (TSP), the predominant LC/MS technique during the1980s, obsolete (15). Numerous reports describing the utility of API/MS for pharmaceutical analysis have appeared in the literature over the last decade (7). The152 Belas and Blairincreased sensitivity that can be attained with API-based methodology, togetherwith the availability of robust instrumentation, has resulted in TSP being phasedout as a practical technique in pharmaceutical analysis. Thus, methodology basedon TSP ionization will not be discussed in detail in this review. The pharmaceutical industry has certainly been at the forefront of implementing API/MS, andthis, perhaps, reflects the utility of this technique for the analysis of pharmaceuticals. Several reviews have appeared recently concerning the use of MS in drugdisposition and pharmacokinetics (6,16-18)." @default.
- W2899100615 created "2018-11-09" @default.
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- W2899100615 date "2001-11-09" @default.
- W2899100615 modified "2023-09-25" @default.
- W2899100615 title "Mass Spectroscopy in Pharmaceutical Analysis" @default.
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- W2899100615 doi "https://doi.org/10.1201/9780203908389-7" @default.
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