Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899100906> ?p ?o ?g. }
- W2899100906 endingPage "1231" @default.
- W2899100906 startingPage "1213" @default.
- W2899100906 abstract "Inflammatory bowel disease (IBD) is characterised by substantial heterogeneity in treatment response. With an expanding number of therapeutic agents, identifying optimal treatment at the patient level remains a major challenge.To systematically review the available literature on predictive biomarkers of therapeutic response in IBD.An electronic literature search was performed on 30 January 2018 using MEDLINE, EMBASE and the Cochrane Library. Retrospective, prospective, uncontrolled and controlled studies reporting on biomarkers predicting therapeutic response in paediatric and adult IBD populations were eligible for inclusion. The methodological quality of the included studies was assessed using the QUIPS tool. Due to anticipated heterogeneity and limited data, a qualitative, rather than quantitative, assessment was planned.Of the 10 638 citations identified, 92 articles met the inclusion criteria. Several potential DNA, mRNA and protein markers were evaluated as predictive biomarkers. Most studies focused on predicting response to anti-TNF agents. Substantial between-study heterogeneity was identified with respect to both the biomarkers studied and the definition of response. None of the included studies received a low risk of bias rating for all six domains. Currently, none of the biomarkers is sufficiently predictive for clinical use.The search for predictive biomarkers is still in its infancy and current evidence is limited. Future research efforts should take into account the high patient heterogeneity within prospective trials with objective response assessment. Predictive models will most likely comprise a combination of several molecular markers from integrated omics-levels and clinical characteristics." @default.
- W2899100906 created "2018-11-09" @default.
- W2899100906 creator A5009248924 @default.
- W2899100906 creator A5031911307 @default.
- W2899100906 creator A5039473882 @default.
- W2899100906 creator A5043362945 @default.
- W2899100906 creator A5055840412 @default.
- W2899100906 creator A5057899912 @default.
- W2899100906 creator A5069015142 @default.
- W2899100906 date "2018-10-30" @default.
- W2899100906 modified "2023-10-17" @default.
- W2899100906 title "Systematic review: predictive biomarkers of therapeutic response in inflammatory bowel disease-personalised medicine in its infancy" @default.
- W2899100906 cites W1530709545 @default.
- W2899100906 cites W1585033336 @default.
- W2899100906 cites W1877806169 @default.
- W2899100906 cites W1881351027 @default.
- W2899100906 cites W1888714951 @default.
- W2899100906 cites W1911418949 @default.
- W2899100906 cites W1927464939 @default.
- W2899100906 cites W1944754896 @default.
- W2899100906 cites W1976817865 @default.
- W2899100906 cites W1984490593 @default.
- W2899100906 cites W1985701112 @default.
- W2899100906 cites W1987542399 @default.
- W2899100906 cites W1997475166 @default.
- W2899100906 cites W2007776780 @default.
- W2899100906 cites W2017466857 @default.
- W2899100906 cites W2021283722 @default.
- W2899100906 cites W2022122363 @default.
- W2899100906 cites W2030063014 @default.
- W2899100906 cites W2043046430 @default.
- W2899100906 cites W2044177835 @default.
- W2899100906 cites W2059306250 @default.
- W2899100906 cites W2059452572 @default.
- W2899100906 cites W2063418390 @default.
- W2899100906 cites W2065603426 @default.
- W2899100906 cites W2068804563 @default.
- W2899100906 cites W2069485958 @default.
- W2899100906 cites W2073375483 @default.
- W2899100906 cites W2074293953 @default.
- W2899100906 cites W2075309439 @default.
- W2899100906 cites W2079185331 @default.
- W2899100906 cites W2081084809 @default.
- W2899100906 cites W2081277484 @default.
- W2899100906 cites W2082977560 @default.
- W2899100906 cites W2084426523 @default.
- W2899100906 cites W2088874765 @default.
- W2899100906 cites W2088905520 @default.
- W2899100906 cites W2094230091 @default.
- W2899100906 cites W2094778049 @default.
- W2899100906 cites W2096433986 @default.
- W2899100906 cites W2100757339 @default.
- W2899100906 cites W2107153099 @default.
- W2899100906 cites W2110468876 @default.
- W2899100906 cites W2113444727 @default.
- W2899100906 cites W2117414671 @default.
- W2899100906 cites W2121569640 @default.
- W2899100906 cites W2122814783 @default.
- W2899100906 cites W2126807394 @default.
- W2899100906 cites W2129558176 @default.
- W2899100906 cites W2133914856 @default.
- W2899100906 cites W2138641630 @default.
- W2899100906 cites W2142327347 @default.
- W2899100906 cites W2144771260 @default.
- W2899100906 cites W2145162151 @default.
- W2899100906 cites W2145245891 @default.
- W2899100906 cites W2146509435 @default.
- W2899100906 cites W2147650285 @default.
- W2899100906 cites W2149170290 @default.
- W2899100906 cites W2161661686 @default.
- W2899100906 cites W2162013416 @default.
- W2899100906 cites W2168654564 @default.
- W2899100906 cites W2171655564 @default.
- W2899100906 cites W2183869328 @default.
- W2899100906 cites W2231837895 @default.
- W2899100906 cites W2274605499 @default.
- W2899100906 cites W2276951042 @default.
- W2899100906 cites W2287623168 @default.
- W2899100906 cites W2288611159 @default.
- W2899100906 cites W2299349192 @default.
- W2899100906 cites W2301536592 @default.
- W2899100906 cites W2314144203 @default.
- W2899100906 cites W2319702696 @default.
- W2899100906 cites W2326234107 @default.
- W2899100906 cites W2329969699 @default.
- W2899100906 cites W2330655337 @default.
- W2899100906 cites W2333191876 @default.
- W2899100906 cites W2339869242 @default.
- W2899100906 cites W2340922368 @default.
- W2899100906 cites W2342554589 @default.
- W2899100906 cites W2398327881 @default.
- W2899100906 cites W2413587463 @default.
- W2899100906 cites W2416252838 @default.
- W2899100906 cites W2468996569 @default.
- W2899100906 cites W2469091829 @default.
- W2899100906 cites W2472319783 @default.
- W2899100906 cites W2479623580 @default.
- W2899100906 cites W2519618731 @default.