Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899124231> ?p ?o ?g. }
- W2899124231 abstract "While genetic advances have successfully defined part of the complexity in Parkinson's disease (PD), the clinical characterization of phenotypes remains challenging. Therapeutic trials and cohort studies typically include patients with earlier disease stages and exclude comorbidities, thus ignoring a substantial part of the real-world PD population. To account for these limitations, we implemented the Luxembourg PD study as a comprehensive clinical, molecular and device-based approach including patients with typical PD and atypical parkinsonism, irrespective of their disease stage, age, comorbidities, or linguistic background. To provide a large, longitudinally followed, and deeply phenotyped set of patients and controls for clinical and fundamental research on PD, we implemented an open-source digital platform that can be harmonized with international PD cohort studies. Our interests also reflect Luxembourg-specific areas of PD research, including vision, gait, and cognition. This effort is flanked by comprehensive biosampling efforts assuring high quality and sustained availability of body liquids and tissue biopsies. We provide evidence for the feasibility of such a cohort program with deep phenotyping and high quality biosampling on parkinsonism in an environment with structural specificities and alert the international research community to our willingness to collaborate with other centers. The combination of advanced clinical phenotyping approaches including device-based assessment will create a comprehensive assessment of the disease and its variants, its interaction with comorbidities and its progression. We envision the Luxembourg Parkinson's study as an important research platform for defining early diagnosis and progression markers that translate into stratified treatment approaches." @default.
- W2899124231 created "2018-11-09" @default.
- W2899124231 creator A5005612416 @default.
- W2899124231 creator A5007123367 @default.
- W2899124231 creator A5019462993 @default.
- W2899124231 creator A5025368869 @default.
- W2899124231 creator A5026277687 @default.
- W2899124231 creator A5026688752 @default.
- W2899124231 creator A5029934888 @default.
- W2899124231 creator A5035408516 @default.
- W2899124231 creator A5039992310 @default.
- W2899124231 creator A5050345786 @default.
- W2899124231 creator A5052812633 @default.
- W2899124231 creator A5057016468 @default.
- W2899124231 creator A5057705571 @default.
- W2899124231 creator A5058911104 @default.
- W2899124231 creator A5064019707 @default.
- W2899124231 creator A5065419751 @default.
- W2899124231 creator A5066411180 @default.
- W2899124231 creator A5066832631 @default.
- W2899124231 creator A5067744605 @default.
- W2899124231 creator A5071418525 @default.
- W2899124231 creator A5072348026 @default.
- W2899124231 creator A5075842572 @default.
- W2899124231 creator A5083629625 @default.
- W2899124231 creator A5088017410 @default.
- W2899124231 creator A5088100702 @default.
- W2899124231 creator A5091086774 @default.
- W2899124231 date "2018-10-29" @default.
- W2899124231 modified "2023-10-10" @default.
- W2899124231 title "The Luxembourg Parkinson’s Study: A Comprehensive Approach for Stratification and Early Diagnosis" @default.
- W2899124231 cites W1561072761 @default.
- W2899124231 cites W1581756795 @default.
- W2899124231 cites W1749720796 @default.
- W2899124231 cites W1803103211 @default.
- W2899124231 cites W1822429118 @default.
- W2899124231 cites W1920030402 @default.
- W2899124231 cites W1932846562 @default.
- W2899124231 cites W1964869491 @default.
- W2899124231 cites W1966760295 @default.
- W2899124231 cites W1970298138 @default.
- W2899124231 cites W1973052762 @default.
- W2899124231 cites W1975629634 @default.
- W2899124231 cites W1976628879 @default.
- W2899124231 cites W1984590571 @default.
- W2899124231 cites W1988494453 @default.
- W2899124231 cites W1990600948 @default.
- W2899124231 cites W1992104307 @default.
- W2899124231 cites W1992476268 @default.
- W2899124231 cites W1997756463 @default.
- W2899124231 cites W2003603265 @default.
- W2899124231 cites W2006957728 @default.
- W2899124231 cites W2008560062 @default.
- W2899124231 cites W2009889181 @default.
- W2899124231 cites W2016109926 @default.
- W2899124231 cites W2023603827 @default.
- W2899124231 cites W2026772921 @default.
- W2899124231 cites W2045659058 @default.
- W2899124231 cites W2048878685 @default.
- W2899124231 cites W2054322764 @default.
- W2899124231 cites W2061840776 @default.
- W2899124231 cites W2063127941 @default.
- W2899124231 cites W2073844807 @default.
- W2899124231 cites W2077789683 @default.
- W2899124231 cites W2093274439 @default.
- W2899124231 cites W2103193738 @default.
- W2899124231 cites W2104608657 @default.
- W2899124231 cites W2106922104 @default.
- W2899124231 cites W2112455323 @default.
- W2899124231 cites W2113749773 @default.
- W2899124231 cites W2116426292 @default.
- W2899124231 cites W2125766898 @default.
- W2899124231 cites W2126008330 @default.
- W2899124231 cites W2131434127 @default.
- W2899124231 cites W2136557657 @default.
- W2899124231 cites W2141459724 @default.
- W2899124231 cites W2148969844 @default.
- W2899124231 cites W2155299862 @default.
- W2899124231 cites W2156013560 @default.
- W2899124231 cites W2157270502 @default.
- W2899124231 cites W2177664723 @default.
- W2899124231 cites W2207405009 @default.
- W2899124231 cites W2252956084 @default.
- W2899124231 cites W2276416625 @default.
- W2899124231 cites W2296350496 @default.
- W2899124231 cites W2329665940 @default.
- W2899124231 cites W2330640534 @default.
- W2899124231 cites W2336519295 @default.
- W2899124231 cites W2338815822 @default.
- W2899124231 cites W2346559312 @default.
- W2899124231 cites W2399600693 @default.
- W2899124231 cites W2439967726 @default.
- W2899124231 cites W2466556386 @default.
- W2899124231 cites W2499433065 @default.
- W2899124231 cites W2510630870 @default.
- W2899124231 cites W2518103242 @default.
- W2899124231 cites W2533946049 @default.
- W2899124231 cites W2559682960 @default.
- W2899124231 cites W2589875191 @default.
- W2899124231 cites W2605481883 @default.