FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899127703> ?p ?o ?g. }

• W2899127703 abstract "Identifying cancer biomarkers from transcriptomics data is of importance to cancer research. However, transcriptomics data are often complex and heterogeneous, which complicates the identification of cancer biomarkers in practice. Currently, the heterogeneity still remains a challenge for detecting subtle but consistent changes of gene expression in cancer cells.In this paper, we propose to adaptively capture the heterogeneity of expression across samples in a gene regulation space instead of in a gene expression space. Specifically, we transform gene expression profiles into gene regulation profiles and mathematically formulate gene regulation probabilities (GRPs)-based statistics for characterizing differential expression of genes between tumor and normal tissues. Finally, an unbiased estimator (aGRP) of GRPs is devised that can interrogate and adaptively capture the heterogeneity of gene expression. We also derived an asymptotical significance analysis procedure for the new statistic. Since no parameter needs to be preset, aGRP is easy and friendly to use for researchers without computer programming background. We evaluated the proposed method on both simulated data and real-world data and compared with previous methods. Experimental results demonstrated the superior performance of the proposed method in exploring the heterogeneity of expression for capturing subtle but consistent alterations of gene expression in cancer.Expression heterogeneity largely influences the performance of cancer biomarker identification from transcriptomics data. Models are needed that efficiently deal with the expression heterogeneity. The proposed method can be a standalone tool due to its capacity of adaptively capturing the sample heterogeneity and the simplicity in use.The source code of aGRP can be downloaded from https://github.com/hqwang126/aGRP ." @default.
• W2899127703 created "2018-11-09" @default.
• W2899127703 creator A5008840047 @default.
• W2899127703 creator A5051036701 @default.
• W2899127703 creator A5077599148 @default.
• W2899127703 creator A5088133476 @default.
• W2899127703 date "2018-11-03" @default.
• W2899127703 modified "2023-10-16" @default.
• W2899127703 title "Adaptively capturing the heterogeneity of expression for cancer biomarker identification" @default.
• W2899127703 cites W1763139064 @default.
• W2899127703 cites W1837170756 @default.
• W2899127703 cites W1982861440 @default.
• W2899127703 cites W2006547416 @default.
• W2899127703 cites W2015840454 @default.
• W2899127703 cites W2023898364 @default.
• W2899127703 cites W2031870285 @default.
• W2899127703 cites W2034564381 @default.
• W2899127703 cites W2039729161 @default.
• W2899127703 cites W2041993682 @default.
• W2899127703 cites W2042209114 @default.
• W2899127703 cites W2045568334 @default.
• W2899127703 cites W2056753605 @default.
• W2899127703 cites W2057929153 @default.
• W2899127703 cites W2059848727 @default.
• W2899127703 cites W2065817349 @default.
• W2899127703 cites W2079781075 @default.
• W2899127703 cites W2100305481 @default.
• W2899127703 cites W2114104545 @default.
• W2899127703 cites W2119034410 @default.
• W2899127703 cites W2126282808 @default.
• W2899127703 cites W2140141449 @default.
• W2899127703 cites W2142384696 @default.
• W2899127703 cites W2143754687 @default.
• W2899127703 cites W2148139839 @default.
• W2899127703 cites W2150778145 @default.
• W2899127703 cites W2152239989 @default.
• W2899127703 cites W2157795344 @default.
• W2899127703 cites W2161828876 @default.
• W2899127703 cites W2167784579 @default.
• W2899127703 cites W2172215633 @default.
• W2899127703 cites W2172358623 @default.
• W2899127703 cites W2179438025 @default.
• W2899127703 cites W2197589217 @default.
• W2899127703 cites W2252918338 @default.
• W2899127703 cites W2283341904 @default.
• W2899127703 cites W2288735625 @default.
• W2899127703 cites W2289109591 @default.
• W2899127703 cites W2395922439 @default.
• W2899127703 cites W2412882418 @default.
• W2899127703 cites W2475073020 @default.
• W2899127703 cites W2515462796 @default.
• W2899127703 cites W2526070630 @default.
• W2899127703 cites W2569105763 @default.
• W2899127703 cites W2573268273 @default.
• W2899127703 cites W2582016570 @default.
• W2899127703 cites W2588585220 @default.
• W2899127703 cites W2619486396 @default.
• W2899127703 cites W2765770547 @default.
• W2899127703 cites W2767931201 @default.
• W2899127703 cites W4294107304 @default.
• W2899127703 doi "https://doi.org/10.1186/s12859-018-2437-2" @default.
• W2899127703 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6215657" @default.
• W2899127703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30390627" @default.
• W2899127703 hasPublicationYear "2018" @default.
• W2899127703 type Work @default.
• W2899127703 sameAs 2899127703 @default.
• W2899127703 citedByCount "1" @default.
• W2899127703 countsByYear W28991277032022 @default.
• W2899127703 crossrefType "journal-article" @default.
• W2899127703 hasAuthorship W2899127703A5008840047 @default.
• W2899127703 hasAuthorship W2899127703A5051036701 @default.
• W2899127703 hasAuthorship W2899127703A5077599148 @default.
• W2899127703 hasAuthorship W2899127703A5088133476 @default.
• W2899127703 hasBestOaLocation W28991277031 @default.
• W2899127703 hasConcept C104317684 @default.
• W2899127703 hasConcept C105795698 @default.
• W2899127703 hasConcept C116834253 @default.
• W2899127703 hasConcept C121608353 @default.
• W2899127703 hasConcept C124101348 @default.
• W2899127703 hasConcept C150194340 @default.
• W2899127703 hasConcept C18431079 @default.
• W2899127703 hasConcept C185429906 @default.
• W2899127703 hasConcept C199360897 @default.
• W2899127703 hasConcept C2777306565 @default.
• W2899127703 hasConcept C33923547 @default.
• W2899127703 hasConcept C41008148 @default.
• W2899127703 hasConcept C54355233 @default.
• W2899127703 hasConcept C59822182 @default.
• W2899127703 hasConcept C70721500 @default.
• W2899127703 hasConcept C86803240 @default.
• W2899127703 hasConcept C90559484 @default.
• W2899127703 hasConcept C95371953 @default.
• W2899127703 hasConceptScore W2899127703C104317684 @default.
• W2899127703 hasConceptScore W2899127703C105795698 @default.
• W2899127703 hasConceptScore W2899127703C116834253 @default.
• W2899127703 hasConceptScore W2899127703C121608353 @default.
• W2899127703 hasConceptScore W2899127703C124101348 @default.
• W2899127703 hasConceptScore W2899127703C150194340 @default.
• W2899127703 hasConceptScore W2899127703C18431079 @default.
• W2899127703 hasConceptScore W2899127703C185429906 @default.

• next