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• W2899130888 abstract "Microfold cells (M cells) are specialized intestinal epithelial cells that initiate mucosal immune responses. These unique phagocytic epithelial cells are specialized for the transfer of a broad range of particulate antigens and microorganisms across the follicle-associated epithelium (FAE) into the gut-associated lymphoid tissue (GALT) by a process termed transcytosis. The molecular basis of antigen uptake by M cells has been gradually identified in the last decade. Active sampling of intestinal antigen initiates regulated immune responses that ensure intestinal homeostasis. The delivery of luminal substances across the intestinal epithelium to the immune system is a critical event in immune surveillance resulting in tolerance to dietary antigens and immunity to pathogens (e.g., bacteria, viruses, and parasites) and their toxins. Several specialized mechanisms transport luminal antigen across the gut epithelium. Discovery of M cell-specific receptors are of great interest, which could act as molecular tags for targeted delivery oral vaccine to M cells. Recent studies demonstrated that M cells utilize several receptors to recognize and transport specific luminal antigens. Vaccination through the mucosal immune system can induce effective systemic immune responses simultaneously with mucosal immunity. How this process is regulated is largely unknown. This review aims to show a new understanding of the factors that influence the development and function of M cells; to show the molecules expressed on M cells which appear to be used as immunosurveillance receptors to sample pathogenic microorganisms in the gut; to note how certain pathogens appear to exploit M cells to inject the host; and, finally, how this knowledge is used to specifically target antigens to M cells to attempt to improve the efficacy of mucosal vaccines. Recently, substantial progress has been made in our understanding of the factors that influence the development and function of M cells." @default.
• W2899130888 created "2018-11-09" @default.
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• W2899130888 date "2018-11-01" @default.
• W2899130888 modified "2023-09-26" @default.
• W2899130888 title "M CELLS ARE THE IMPORTANT POST IN THE INITIATION OF IMMUNE RESPONSE IN INTESTINE" @default.
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• W2899130888 cites W1777407783 @default.
• W2899130888 cites W1897082935 @default.
• W2899130888 cites W1903553077 @default.
• W2899130888 cites W1955079753 @default.
• W2899130888 cites W1968106422 @default.
• W2899130888 cites W1968291110 @default.
• W2899130888 cites W1969564240 @default.
• W2899130888 cites W1975414229 @default.
• W2899130888 cites W1982603620 @default.
• W2899130888 cites W1991043494 @default.
• W2899130888 cites W1998392341 @default.
• W2899130888 cites W1999235506 @default.
• W2899130888 cites W2001712372 @default.
• W2899130888 cites W2003111539 @default.
• W2899130888 cites W2005665370 @default.
• W2899130888 cites W2015086458 @default.
• W2899130888 cites W2016388804 @default.
• W2899130888 cites W2021920348 @default.
• W2899130888 cites W2024406183 @default.
• W2899130888 cites W2025853891 @default.
• W2899130888 cites W2032470192 @default.
• W2899130888 cites W2035376519 @default.
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• W2899130888 cites W2060961202 @default.
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• W2899130888 cites W2061840254 @default.
• W2899130888 cites W2076218911 @default.
• W2899130888 cites W2080648518 @default.
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• W2899130888 cites W2109325879 @default.
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• W2899130888 cites W2116339721 @default.
• W2899130888 cites W2116912890 @default.
• W2899130888 cites W2130079153 @default.
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• W2899130888 doi "https://doi.org/10.15789/2220-7619-2018-3-263-272" @default.
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