Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899151115> ?p ?o ?g. }
- W2899151115 endingPage "5089" @default.
- W2899151115 startingPage "5083" @default.
- W2899151115 abstract "DKK1 is an antagonist of the Wnt signaling pathway that has various roles in human physiology. Notably, aberrant DKK1 expression is observed in several cancers. In this retrospective study, we assessed the association between DKK1 expression levels and head and neck squamous cell carcinoma (HNSCC) and its prognostic value.Using RNA-seq data from HNSCC tumors (N=520) and adjacent normal tissue (N=44) in The Cancer Genome Atlas, we evaluated DKK1 expression levels. Additionally, we evaluated the association of DKK1 expression levels and pathophysiological features of patients with HNSCC and the value of DKK1 expression for prediction of overall survival (OS). We also explored the correlation between DKK1 expression and methylation of its promoter in HNSCC.DKK1 expression was significantly upregulated in HNSCC compared with normal tissues. Moreover, DKK1 expression was significantly associated with smoking, alcohol abuse, sex, human papillomavirus status, tumor site, tumor invasion, and pathologic stage in HNSCC patients. Kaplan-Meier curves showed that high DKK1 expression was correlated with inferior OS. In addition, univariate and multivariate analyses showed that elevated DKK1 expression was an independent prognostic factor for poor OS (HR: 1.85, 95% CI: 1.31-2.62, P<0.001). Regression analysis identified a strong negative correlation between DKK1 expression and methylation of its promoter.These findings support the hypothesis that elevated DKK1 expression is modulated via methylation of its promoter and indicate that DKK1 expression is a highly informative prognostic biomarker for patients with HNSCC." @default.
- W2899151115 created "2018-11-09" @default.
- W2899151115 creator A5010710133 @default.
- W2899151115 creator A5021845548 @default.
- W2899151115 creator A5025095425 @default.
- W2899151115 creator A5050292476 @default.
- W2899151115 creator A5050400737 @default.
- W2899151115 creator A5058188181 @default.
- W2899151115 creator A5088910746 @default.
- W2899151115 date "2018-10-01" @default.
- W2899151115 modified "2023-09-23" @default.
- W2899151115 title "Elevated <em>DKK1</em> expression is an independent unfavorable prognostic indicator of survival in head and neck squamous cell carcinoma" @default.
- W2899151115 cites W1483209550 @default.
- W2899151115 cites W1898960514 @default.
- W2899151115 cites W1966638197 @default.
- W2899151115 cites W1971085650 @default.
- W2899151115 cites W1971820657 @default.
- W2899151115 cites W1981646010 @default.
- W2899151115 cites W1984178544 @default.
- W2899151115 cites W2016412105 @default.
- W2899151115 cites W2017653601 @default.
- W2899151115 cites W2043536378 @default.
- W2899151115 cites W2046893938 @default.
- W2899151115 cites W2067758224 @default.
- W2899151115 cites W2086309022 @default.
- W2899151115 cites W2110435930 @default.
- W2899151115 cites W2117286343 @default.
- W2899151115 cites W2141024484 @default.
- W2899151115 cites W2145078756 @default.
- W2899151115 cites W2146685970 @default.
- W2899151115 cites W2158485828 @default.
- W2899151115 cites W2171982488 @default.
- W2899151115 cites W2288651793 @default.
- W2899151115 cites W2411509802 @default.
- W2899151115 cites W2414471948 @default.
- W2899151115 cites W2535284666 @default.
- W2899151115 cites W2570618306 @default.
- W2899151115 cites W2588762023 @default.
- W2899151115 cites W2607019549 @default.
- W2899151115 cites W2623583310 @default.
- W2899151115 cites W2742323676 @default.
- W2899151115 cites W2748132935 @default.
- W2899151115 cites W2781525129 @default.
- W2899151115 cites W2791931142 @default.
- W2899151115 cites W2793740197 @default.
- W2899151115 cites W2800413612 @default.
- W2899151115 cites W2805068318 @default.
- W2899151115 cites W2906821152 @default.
- W2899151115 doi "https://doi.org/10.2147/cmar.s177043" @default.
- W2899151115 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6215925" @default.
- W2899151115 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30464608" @default.
- W2899151115 hasPublicationYear "2018" @default.
- W2899151115 type Work @default.
- W2899151115 sameAs 2899151115 @default.
- W2899151115 citedByCount "18" @default.
- W2899151115 countsByYear W28991511152019 @default.
- W2899151115 countsByYear W28991511152020 @default.
- W2899151115 countsByYear W28991511152021 @default.
- W2899151115 countsByYear W28991511152022 @default.
- W2899151115 countsByYear W28991511152023 @default.
- W2899151115 crossrefType "journal-article" @default.
- W2899151115 hasAuthorship W2899151115A5010710133 @default.
- W2899151115 hasAuthorship W2899151115A5021845548 @default.
- W2899151115 hasAuthorship W2899151115A5025095425 @default.
- W2899151115 hasAuthorship W2899151115A5050292476 @default.
- W2899151115 hasAuthorship W2899151115A5050400737 @default.
- W2899151115 hasAuthorship W2899151115A5058188181 @default.
- W2899151115 hasAuthorship W2899151115A5088910746 @default.
- W2899151115 hasBestOaLocation W28991511151 @default.
- W2899151115 hasConcept C104317684 @default.
- W2899151115 hasConcept C121608353 @default.
- W2899151115 hasConcept C126322002 @default.
- W2899151115 hasConcept C137620995 @default.
- W2899151115 hasConcept C142724271 @default.
- W2899151115 hasConcept C143998085 @default.
- W2899151115 hasConcept C150194340 @default.
- W2899151115 hasConcept C190727270 @default.
- W2899151115 hasConcept C204232928 @default.
- W2899151115 hasConcept C2776530083 @default.
- W2899151115 hasConcept C2776833033 @default.
- W2899151115 hasConcept C2777491412 @default.
- W2899151115 hasConcept C2781197716 @default.
- W2899151115 hasConcept C33288867 @default.
- W2899151115 hasConcept C502942594 @default.
- W2899151115 hasConcept C55493867 @default.
- W2899151115 hasConcept C62478195 @default.
- W2899151115 hasConcept C71924100 @default.
- W2899151115 hasConcept C86803240 @default.
- W2899151115 hasConceptScore W2899151115C104317684 @default.
- W2899151115 hasConceptScore W2899151115C121608353 @default.
- W2899151115 hasConceptScore W2899151115C126322002 @default.
- W2899151115 hasConceptScore W2899151115C137620995 @default.
- W2899151115 hasConceptScore W2899151115C142724271 @default.
- W2899151115 hasConceptScore W2899151115C143998085 @default.
- W2899151115 hasConceptScore W2899151115C150194340 @default.
- W2899151115 hasConceptScore W2899151115C190727270 @default.
- W2899151115 hasConceptScore W2899151115C204232928 @default.
- W2899151115 hasConceptScore W2899151115C2776530083 @default.