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• W2899154426 abstract "The caffeine metabolic ratio is an established marker for cytochrome P450 ( CYP ) 1A2 activity. Optimal sample size calculation for clinical pharmacokinetic xenobiotic–caffeine interaction studies requires robust estimates of interindividual and intraindividual variation in this ratio. Compared with interindividual variation, factors contributing to intraindividual variation are less defined. An exploratory analysis involving healthy nonsmoking non‐naïve caffeine drinkers (1–3 cups/day; 12 men, 12 women) administered caffeine (160 mg) on five occasions evaluated the effects of CYP 1A2 induction status (based on genotype) and other factors on intraindividual variation in CYP 1A2 activity. Results were compared with those from previous studies. Regardless of whether a hyperinducer ( CYP 1A2*1A/*1F or CYP 1A2*1F/*1F ) or normal metabolizer ( CYP 1A2*1A/*1A , CYP 1A2*1C/*1F , or CYP 1A2*1C*1F/*1C*1F ), sex, age, oral contraceptive use by women, and smoking status, intraindividual variation was ≤30%. A value of 30% is proposed for optimal design of pharmacokinetic xenobiotic–caffeine interaction studies. Prospective studies are needed for confirmation." @default.
• W2899154426 created "2018-11-09" @default.
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• W2899154426 date "2018-11-26" @default.
• W2899154426 modified "2023-10-17" @default.
• W2899154426 title "Effects of Common <i><scp>CYP</scp>1A2</i> Genotypes and Other Key Factors on Intraindividual Variation in the Caffeine Metabolic Ratio: An Exploratory Analysis" @default.
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• W2899154426 doi "https://doi.org/10.1111/cts.12598" @default.
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