Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899155229> ?p ?o ?g. }
- W2899155229 abstract "With the advent of advanced sequencing technology, studies of RNA viruses have shown that genetic diversity can contribute to both attenuation and virulence and the paradigm is that this is controlled by the error-prone RNA-dependent RNA polymerase (RdRp). Since wild-type yellow fever virus (YFV) strain Asibi has genetic diversity typical of a wild-type RNA virus, while 17D virus vaccine has limited diversity, it provides a unique opportunity to investigate RNA population theory in the context of a well-characterized live attenuated vaccine. Utilizing infectious clone-derived viruses, we show that genetic diversity of RNA viruses is complex and that multiple genes, including structural genes and NS2B and NS4B genes also contribute to genetic diversity. We suggest that the replication complex as a whole, rather than only RdRp, drives genetic diversity, at least for YFV." @default.
- W2899155229 created "2018-11-09" @default.
- W2899155229 creator A5001816949 @default.
- W2899155229 creator A5045786709 @default.
- W2899155229 creator A5052470692 @default.
- W2899155229 creator A5053933491 @default.
- W2899155229 creator A5064167258 @default.
- W2899155229 creator A5084228417 @default.
- W2899155229 date "2018-11-07" @default.
- W2899155229 modified "2023-09-29" @default.
- W2899155229 title "Structural and Nonstructural Genes Contribute to the Genetic Diversity of RNA Viruses" @default.
- W2899155229 cites W1031737100 @default.
- W2899155229 cites W1186520945 @default.
- W2899155229 cites W1785470120 @default.
- W2899155229 cites W1972928030 @default.
- W2899155229 cites W1978711639 @default.
- W2899155229 cites W1980523796 @default.
- W2899155229 cites W1980974151 @default.
- W2899155229 cites W1987253731 @default.
- W2899155229 cites W1994278598 @default.
- W2899155229 cites W1996824979 @default.
- W2899155229 cites W1997854511 @default.
- W2899155229 cites W1999464123 @default.
- W2899155229 cites W2000241775 @default.
- W2899155229 cites W2003574450 @default.
- W2899155229 cites W2008216856 @default.
- W2899155229 cites W2008922519 @default.
- W2899155229 cites W2020934094 @default.
- W2899155229 cites W2021948973 @default.
- W2899155229 cites W2030100825 @default.
- W2899155229 cites W2047550464 @default.
- W2899155229 cites W2050552757 @default.
- W2899155229 cites W2053085788 @default.
- W2899155229 cites W2057711709 @default.
- W2899155229 cites W2058741785 @default.
- W2899155229 cites W2060396584 @default.
- W2899155229 cites W2061241820 @default.
- W2899155229 cites W2064930197 @default.
- W2899155229 cites W2066713215 @default.
- W2899155229 cites W2074776659 @default.
- W2899155229 cites W2083870945 @default.
- W2899155229 cites W2087854601 @default.
- W2899155229 cites W2097088780 @default.
- W2899155229 cites W2097790240 @default.
- W2899155229 cites W2105382692 @default.
- W2899155229 cites W2111287018 @default.
- W2899155229 cites W2114361850 @default.
- W2899155229 cites W2123387190 @default.
- W2899155229 cites W2124437637 @default.
- W2899155229 cites W2130924724 @default.
- W2899155229 cites W2134851132 @default.
- W2899155229 cites W2148882270 @default.
- W2899155229 cites W2150640493 @default.
- W2899155229 cites W2156269187 @default.
- W2899155229 cites W2159093669 @default.
- W2899155229 cites W2161406362 @default.
- W2899155229 cites W2168197672 @default.
- W2899155229 cites W2239414039 @default.
- W2899155229 cites W2318914164 @default.
- W2899155229 cites W2324935422 @default.
- W2899155229 cites W2403926347 @default.
- W2899155229 cites W2461540377 @default.
- W2899155229 cites W2560953325 @default.
- W2899155229 cites W2594592790 @default.
- W2899155229 cites W2767325100 @default.
- W2899155229 cites W2772556009 @default.
- W2899155229 cites W763093762 @default.
- W2899155229 doi "https://doi.org/10.1128/mbio.01871-18" @default.
- W2899155229 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6212827" @default.
- W2899155229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30377281" @default.
- W2899155229 hasPublicationYear "2018" @default.
- W2899155229 type Work @default.
- W2899155229 sameAs 2899155229 @default.
- W2899155229 citedByCount "27" @default.
- W2899155229 countsByYear W28991552292019 @default.
- W2899155229 countsByYear W28991552292020 @default.
- W2899155229 countsByYear W28991552292021 @default.
- W2899155229 countsByYear W28991552292022 @default.
- W2899155229 countsByYear W28991552292023 @default.
- W2899155229 crossrefType "journal-article" @default.
- W2899155229 hasAuthorship W2899155229A5001816949 @default.
- W2899155229 hasAuthorship W2899155229A5045786709 @default.
- W2899155229 hasAuthorship W2899155229A5052470692 @default.
- W2899155229 hasAuthorship W2899155229A5053933491 @default.
- W2899155229 hasAuthorship W2899155229A5064167258 @default.
- W2899155229 hasAuthorship W2899155229A5084228417 @default.
- W2899155229 hasBestOaLocation W28991552291 @default.
- W2899155229 hasConcept C104317684 @default.
- W2899155229 hasConcept C144024400 @default.
- W2899155229 hasConcept C149923435 @default.
- W2899155229 hasConcept C151730666 @default.
- W2899155229 hasConcept C159047783 @default.
- W2899155229 hasConcept C2522874641 @default.
- W2899155229 hasConcept C2776449523 @default.
- W2899155229 hasConcept C2779174946 @default.
- W2899155229 hasConcept C2779343474 @default.
- W2899155229 hasConcept C2908647359 @default.
- W2899155229 hasConcept C41258723 @default.
- W2899155229 hasConcept C54355233 @default.
- W2899155229 hasConcept C60987743 @default.