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- W2899169666 abstract "Currently, transcranial hypophysectomy is infrequently used since the trans-sphenoidal approach isvery effective and less invasive. Prolactinomas represent one of the rarest indications for pituitarysurgery due to the spectacular effects of dopamine agonists as cabergoline. A 66-year-old femalepresented at age of 52 with headache, low blood pressure. The investigations revealedpanhypopituitarism, high prolactin and a large pituitary mass with obstructive hydrocephalus at theleft lateral ventricle. Transcranial surgery was performed through a right approach withoutcomplications. The pathological report confirmed a pituitary adenoma with intense cellularpleomorphism. A 29-year-old male was admitted at the age of 28 for severe headache, multipleepisodes of vomiting, and hypotension. Pituitary insufficiency and hyperprolactinemia werecorrelated to the presence of an intrasellar tumor of 2/2 cm with extension to the right cavernoussinus, optic chiasm. The pathological report confirmed a pituitary adenoma. Transcranial pituitarysurgery represents an option only in selected large macroprolactinomas. After procedure, a goodoutcome is expected despite the potential secondary eye field defects or pituitary insufficiencywhich needs medication. Sometime the panhypopituitarism caused first by the tumor itself persistsafter surgery (as in our first case) or it is corrected (as adrenal insufficiency in the second case).The presence of a residual prolactin producing tumor requires long term specific therapy withdopamine agonists." @default.
- W2899169666 created "2018-11-09" @default.
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- W2899169666 date "2016-03-10" @default.
- W2899169666 modified "2023-10-16" @default.
- W2899169666 title "LONG-TERM FOLLOW-UP AFTER TRANSCRANIAL HYPOPHYSECTOMY IN MACROPROLACTINOMAS" @default.
- W2899169666 doi "https://doi.org/10.33695/jss.v3i1.47" @default.
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