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- W2899171603 abstract "Accumulating evidence indicates that the anti‑CD20 monoclonal antibody rituximab significantly improves the clinical prognosis of patients with non‑Hodgkin lymphoma and chronic lymphocytic leukemia. However, a number of patients relapse or fail to respond to rituximab. To further understand the cause of this, polymorphisms of FcγRIIIa were initially detected in healthy volunteers. Subsequently, the rituximab‑dependent natural killer (NK) cell‑mediated cytotoxicity of different FcγRIIIa genotypes was assessed by a cytotoxicity assay in vitro. Ultimately, the effect of human serum immunoglobulin (Ig) G and complement on rituximab‑dependent NK cell‑mediated cytotoxicity was evaluated in vitro. It was revealed that FcγRIIIa polymorphisms were associated with the antibody‑dependent cell‑mediated cytotoxicity (ADCC) of NK cells. In addition, the ADCC of NK cells with FcγRIIIa‑158 V/V was increased compared with that of FcγRIIIa‑158 V/F. The serum IgG and rituximab Fc segment was able to bind competitively with NK cell FcγRIIIa. It was observed that serum IgG inhibited, whereas complement enhanced rituximab‑induced NK‑cell mediated ADCC. Therefore, various agents administered synchronously with rituximab may modulate the efficacy of this agent and ultimately its toxicity against tumor cells." @default.
- W2899171603 created "2018-11-09" @default.
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- W2899171603 date "2018-10-29" @default.
- W2899171603 modified "2023-09-27" @default.
- W2899171603 title "Effects of complement and serum IgG on rituximab‑dependent natural killer cell‑mediated cytotoxicity against Raji cells" @default.
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- W2899171603 doi "https://doi.org/10.3892/ol.2018.9630" @default.
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