Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899174501> ?p ?o ?g. }
- W2899174501 endingPage "216" @default.
- W2899174501 startingPage "208" @default.
- W2899174501 abstract "Background Contact allergy to oxidized limonene, with hydroperoxides of limonene (Lim‐OOHs) as the main allergens, is common. However, high proportions of weak positive and doubtful patch test reactions have been reported. Objectives To determine the clinical relevance, elicitation threshold and dose‐response relationship of Lim‐OOHs in individuals with a positive or doubtful patch test reaction to standard Lim‐OOHs 0.3% pet. Methods A multicentre 3‐week double‐blind vehicle‐controlled repeated open application test (ROAT) study with a simulated fine fragrance containing Lim‐OOHs at 1260, 420 and 140 ppm, equal to a dose/area per application of Lim‐OOHs of 3.0, 0.99 and 0.33 μg/cm 2 , was performed. Results Among 11 subjects allergic to Lim‐OOHs, 11 (100%), 7 (64%), and 3 (27%), respectively, reacted to the applied doses. No reactions were seen in 17 healthy controls exposed to the highest dose. This difference in reactivity was statistically significant ( P < 0.0001). Among 13 subjects with doubtful patch test reactions to Lim‐OOHs, two (15%) had positive ROAT reactions to the highest Lim‐OOH dose applied ( P = 0.36 as compared with controls). Conclusions Contact allergy to Lim‐OOHs is of clinical relevance in patients with positive patch test reactions. A doubtful patch test reaction to Lim‐OOHs 0.3% pet. can be of clinical relevance." @default.
- W2899174501 created "2018-11-09" @default.
- W2899174501 creator A5003068681 @default.
- W2899174501 creator A5029653086 @default.
- W2899174501 creator A5042525152 @default.
- W2899174501 creator A5049430973 @default.
- W2899174501 creator A5064209161 @default.
- W2899174501 creator A5077648441 @default.
- W2899174501 creator A5089158736 @default.
- W2899174501 date "2018-12-12" @default.
- W2899174501 modified "2023-10-17" @default.
- W2899174501 title "Allergic contact dermatitis caused by hydroperoxides of limonene and dose‐response relationship—A repeated open application test (ROAT) study" @default.
- W2899174501 cites W1554982925 @default.
- W2899174501 cites W1565539247 @default.
- W2899174501 cites W1589472332 @default.
- W2899174501 cites W1906801702 @default.
- W2899174501 cites W1925826508 @default.
- W2899174501 cites W1981186227 @default.
- W2899174501 cites W1983887467 @default.
- W2899174501 cites W2000577812 @default.
- W2899174501 cites W2005463192 @default.
- W2899174501 cites W2010156224 @default.
- W2899174501 cites W2015237781 @default.
- W2899174501 cites W2022644173 @default.
- W2899174501 cites W2029016338 @default.
- W2899174501 cites W2053134332 @default.
- W2899174501 cites W2065290063 @default.
- W2899174501 cites W2069524902 @default.
- W2899174501 cites W2076480642 @default.
- W2899174501 cites W2097030810 @default.
- W2899174501 cites W2106957263 @default.
- W2899174501 cites W2109772062 @default.
- W2899174501 cites W2110358899 @default.
- W2899174501 cites W2141079808 @default.
- W2899174501 cites W2145748778 @default.
- W2899174501 cites W2170916865 @default.
- W2899174501 cites W2558661299 @default.
- W2899174501 cites W2613691229 @default.
- W2899174501 cites W2615223771 @default.
- W2899174501 cites W2743789832 @default.
- W2899174501 cites W2796234152 @default.
- W2899174501 cites W2805074791 @default.
- W2899174501 cites W2808887337 @default.
- W2899174501 cites W4292528167 @default.
- W2899174501 doi "https://doi.org/10.1111/cod.13168" @default.
- W2899174501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30378136" @default.
- W2899174501 hasPublicationYear "2018" @default.
- W2899174501 type Work @default.
- W2899174501 sameAs 2899174501 @default.
- W2899174501 citedByCount "35" @default.
- W2899174501 countsByYear W28991745012019 @default.
- W2899174501 countsByYear W28991745012020 @default.
- W2899174501 countsByYear W28991745012021 @default.
- W2899174501 countsByYear W28991745012022 @default.
- W2899174501 countsByYear W28991745012023 @default.
- W2899174501 crossrefType "journal-article" @default.
- W2899174501 hasAuthorship W2899174501A5003068681 @default.
- W2899174501 hasAuthorship W2899174501A5029653086 @default.
- W2899174501 hasAuthorship W2899174501A5042525152 @default.
- W2899174501 hasAuthorship W2899174501A5049430973 @default.
- W2899174501 hasAuthorship W2899174501A5064209161 @default.
- W2899174501 hasAuthorship W2899174501A5077648441 @default.
- W2899174501 hasAuthorship W2899174501A5089158736 @default.
- W2899174501 hasConcept C140764562 @default.
- W2899174501 hasConcept C16005928 @default.
- W2899174501 hasConcept C185592680 @default.
- W2899174501 hasConcept C203014093 @default.
- W2899174501 hasConcept C207480886 @default.
- W2899174501 hasConcept C2776056826 @default.
- W2899174501 hasConcept C2776134268 @default.
- W2899174501 hasConcept C2777278459 @default.
- W2899174501 hasConcept C2778091633 @default.
- W2899174501 hasConcept C2994354051 @default.
- W2899174501 hasConcept C2994436531 @default.
- W2899174501 hasConcept C3019149831 @default.
- W2899174501 hasConcept C3020497150 @default.
- W2899174501 hasConcept C31903555 @default.
- W2899174501 hasConcept C71924100 @default.
- W2899174501 hasConceptScore W2899174501C140764562 @default.
- W2899174501 hasConceptScore W2899174501C16005928 @default.
- W2899174501 hasConceptScore W2899174501C185592680 @default.
- W2899174501 hasConceptScore W2899174501C203014093 @default.
- W2899174501 hasConceptScore W2899174501C207480886 @default.
- W2899174501 hasConceptScore W2899174501C2776056826 @default.
- W2899174501 hasConceptScore W2899174501C2776134268 @default.
- W2899174501 hasConceptScore W2899174501C2777278459 @default.
- W2899174501 hasConceptScore W2899174501C2778091633 @default.
- W2899174501 hasConceptScore W2899174501C2994354051 @default.
- W2899174501 hasConceptScore W2899174501C2994436531 @default.
- W2899174501 hasConceptScore W2899174501C3019149831 @default.
- W2899174501 hasConceptScore W2899174501C3020497150 @default.
- W2899174501 hasConceptScore W2899174501C31903555 @default.
- W2899174501 hasConceptScore W2899174501C71924100 @default.
- W2899174501 hasFunder F4320323742 @default.
- W2899174501 hasIssue "4" @default.
- W2899174501 hasLocation W28991745011 @default.
- W2899174501 hasLocation W28991745012 @default.
- W2899174501 hasOpenAccess W2899174501 @default.