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- W2899179634 abstract "Persicae semen was used as folk remedy for regulating pulmonary inflammatory diseases in traditional oriental medicine. In the prersent study, we investigated whether prunasin, erucic acid or daucosterol derived from Persicae semen affects airway MUC5AC mucin gene expression and production, induced by phorbol 12-myristate 13-acetate (PMA) or epi-dermal growth factor (EGF) from NCI-H292 cells. Confluent cells were pretreated with each agent for 30 min and then stim-ulated with PMA or EGF for 24h. The MUC5AC mucin gene expression was measured by RT-PCR (Reverse Transcription-Polymerase Chain Reaction). Production of MUC5AC mucin protein was measured by enzyme-linked immunosorbent assay (ELISA). The results were as follows: (1) Erucic acid inhibited the gene expression and production of MUC5AC mucin from NCI-H292 cells; (2) Daucosterol also inhibited the gene expression and production of MUC5AC mucin from NCI-H292 cells. This result suggests that erucic acid or daucosterol can inhibit the production and gene expression of mucin induced by PMA or EGF, through directly acting on airway epithelial cells." @default.
- W2899179634 created "2018-11-09" @default.
- W2899179634 creator A5021284354 @default.
- W2899179634 date "2018-08-30" @default.
- W2899179634 modified "2023-10-16" @default.
- W2899179634 title "Effects of Natural Products Derived from Persicae Semen including Daucosterol on gene Expression and Production of Respiratory Mucin induced by Growth Factor and Phorbol Ester" @default.
- W2899179634 doi "https://doi.org/10.17480/psk.2018.62.4.284" @default.
- W2899179634 hasPublicationYear "2018" @default.
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