FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899187179> ?p ?o ?g. }

• W2899187179 endingPage "3809" @default.
• W2899187179 startingPage "3800" @default.
• W2899187179 abstract "Approximately 6.3 million bone fractures occur annually in the United States, resulting in considerable morbidity, deterioration in quality of life, loss of productivity and wages, and sometimes death (e.g., hip fractures). Although anabolic and antiresorptive agents have been introduced for treatment of osteoporosis, no systemically administered drug has been developed to accelerate the fracture-healing process. To address this need, we have undertaken to target a bone anabolic agent selectively to fracture surfaces in order to concentrate the drug’s healing power directly on the fracture site. We report here that conjugation of dasatinib to a bone fracture-homing oligopeptide via a releasable linker reduces fractured femur healing times in mice by ∼60% without causing overt off-target toxicity or remodeling of nontraumatized bones. Thus, achievement of healthy bone density, normal bone volume, and healthy bone mechanical properties at the fracture site is realized after only 3–4 weeks in dasatinib-targeted mice, but it requires ∼8 weeks in PBS-treated controls. We conclude that targeting of dasatinib to bone fracture surfaces can significantly accelerate the healing process at dasatinib concentrations that are known to be safe in oncological applications." @default.
• W2899187179 created "2018-11-09" @default.
• W2899187179 creator A5012446734 @default.
• W2899187179 creator A5014120936 @default.
• W2899187179 creator A5020223005 @default.
• W2899187179 creator A5028852072 @default.
• W2899187179 creator A5068062942 @default.
• W2899187179 creator A5072966635 @default.
• W2899187179 creator A5088752165 @default.
• W2899187179 date "2018-10-31" @default.
• W2899187179 modified "2023-09-24" @default.
• W2899187179 title "Bone-Fracture-Targeted Dasatinib-Oligoaspartic Acid Conjugate Potently Accelerates Fracture Repair" @default.
• W2899187179 cites W1480870442 @default.
• W2899187179 cites W1542330291 @default.
• W2899187179 cites W1968353260 @default.
• W2899187179 cites W1975953388 @default.
• W2899187179 cites W1976883253 @default.
• W2899187179 cites W1983978481 @default.
• W2899187179 cites W1984743383 @default.
• W2899187179 cites W1988586881 @default.
• W2899187179 cites W1988622995 @default.
• W2899187179 cites W1988837817 @default.
• W2899187179 cites W1989631152 @default.
• W2899187179 cites W1994855451 @default.
• W2899187179 cites W2000170431 @default.
• W2899187179 cites W2006585716 @default.
• W2899187179 cites W2011350479 @default.
• W2899187179 cites W2013300935 @default.
• W2899187179 cites W2015423024 @default.
• W2899187179 cites W2049953991 @default.
• W2899187179 cites W2052914763 @default.
• W2899187179 cites W2053910616 @default.
• W2899187179 cites W2055664745 @default.
• W2899187179 cites W2059650971 @default.
• W2899187179 cites W2066749771 @default.
• W2899187179 cites W2076587628 @default.
• W2899187179 cites W2083328029 @default.
• W2899187179 cites W2086859574 @default.
• W2899187179 cites W2093395043 @default.
• W2899187179 cites W2096425957 @default.
• W2899187179 cites W2101155756 @default.
• W2899187179 cites W2122118178 @default.
• W2899187179 cites W2124167914 @default.
• W2899187179 cites W2153676930 @default.
• W2899187179 cites W2155671766 @default.
• W2899187179 cites W2159651819 @default.
• W2899187179 cites W2161143036 @default.
• W2899187179 cites W2170744486 @default.
• W2899187179 cites W2290466312 @default.
• W2899187179 cites W2292105952 @default.
• W2899187179 cites W2327381249 @default.
• W2899187179 cites W2335178464 @default.
• W2899187179 cites W2344240164 @default.
• W2899187179 cites W2436450428 @default.
• W2899187179 cites W2439930002 @default.
• W2899187179 cites W2530388020 @default.
• W2899187179 cites W2561669056 @default.
• W2899187179 cites W2565573303 @default.
• W2899187179 cites W2574245894 @default.
• W2899187179 cites W2765797682 @default.
• W2899187179 cites W2767402465 @default.
• W2899187179 cites W2778990341 @default.
• W2899187179 cites W2792392055 @default.
• W2899187179 cites W2800472668 @default.
• W2899187179 cites W3021861218 @default.
• W2899187179 cites W4254310590 @default.
• W2899187179 cites W996178345 @default.
• W2899187179 doi "https://doi.org/10.1021/acs.bioconjchem.8b00660" @default.
• W2899187179 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30380292" @default.
• W2899187179 hasPublicationYear "2018" @default.
• W2899187179 type Work @default.
• W2899187179 sameAs 2899187179 @default.
• W2899187179 citedByCount "15" @default.
• W2899187179 countsByYear W28991871792018 @default.
• W2899187179 countsByYear W28991871792019 @default.
• W2899187179 countsByYear W28991871792020 @default.
• W2899187179 countsByYear W28991871792021 @default.
• W2899187179 countsByYear W28991871792022 @default.
• W2899187179 crossrefType "journal-article" @default.
• W2899187179 hasAuthorship W2899187179A5012446734 @default.
• W2899187179 hasAuthorship W2899187179A5014120936 @default.
• W2899187179 hasAuthorship W2899187179A5020223005 @default.
• W2899187179 hasAuthorship W2899187179A5028852072 @default.
• W2899187179 hasAuthorship W2899187179A5068062942 @default.
• W2899187179 hasAuthorship W2899187179A5072966635 @default.
• W2899187179 hasAuthorship W2899187179A5088752165 @default.
• W2899187179 hasConcept C126322002 @default.
• W2899187179 hasConcept C141071460 @default.
• W2899187179 hasConcept C170033053 @default.
• W2899187179 hasConcept C170493617 @default.
• W2899187179 hasConcept C185592680 @default.
• W2899187179 hasConcept C2776541429 @default.
• W2899187179 hasConcept C2779329777 @default.
• W2899187179 hasConcept C2779536868 @default.
• W2899187179 hasConcept C2780554211 @default.
• W2899187179 hasConcept C2911223091 @default.
• W2899187179 hasConcept C42362537 @default.
• W2899187179 hasConcept C71924100 @default.

• next