Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899189234> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2899189234 endingPage "164" @default.
- W2899189234 startingPage "140" @default.
- W2899189234 abstract "Introduction: Human parvovirus B19 (B19V) is small non-enveloped, single-stranded DNA virus belong to genus Erythrovirus. B19V can cause erythema infectiosum (fifth disease), oligoarthritis, hydrops fetalis and a plastic crisis in patients with sickle cell anemia. A variety of vaccine strategies have been employed targeting immune responses. However their results were controversy with a limiting in availability of viral antigen. Since B19V replicates predominantly in erythroid progenitor cells of human bone marrow, this makes a peptide-based vaccines a promising strategy for development of vaccine against B19V with less allergenic and reactogenic responses. The aim of the present study was to design an efficient multi-epitope vaccine for human B19 virus using VP1 glycoprotein. Material and method: Thirty six sequences of VP1 glycoprotein were retrieved from NCBI database in December 2017 and aligned to determine the conservancy between the retrieved strains. The IEDB different analysis resources were used to predict epitopes that could act as promising peptides vaccine against parvovirus B19. The predicted epitopes were further assessed for population coverage against the whole world population. Results: The epitopes 214-PEVP-217, 675-GLHQPPP-681 and 554-SLRPGPVSQPYH-565 were found to be the most potential epitopes against B cells. For the T cell three epitopes namely 155-FRYSQLAKL-163, 302-CTISPIMGY-310 and 316-YLDFNALNL-324 showed high affinity to MHC-I alleles. The epitopes (core) 155-FRYSQLAKL-163, 438-FYVLEHSSF-446 and 404-WVYFPPQYA-412 showed high affinity to interact with MHC-II alleles. 155-FRYSQLAKL-163 and 438-FYVLEHSSF-446 showed high coverage for whole world population with percentage of 99.73% and 94.85% respectively. Conclusion: This study proposed eight epitopes for B and T cells that could be a powerful multi epitope vaccine against B19V. Particular concern directed towards the epitope 155-FRYSQLAKL-163 which demonstrated merits by reacting efficiently with both MHC-I and MHC-II alleles. Clinical trial is required to proof the efficacy of these epitopes as promising candidate vaccine against parvovirus B19." @default.
- W2899189234 created "2018-11-09" @default.
- W2899189234 creator A5029605964 @default.
- W2899189234 creator A5047635665 @default.
- W2899189234 creator A5072603571 @default.
- W2899189234 date "2018-08-14" @default.
- W2899189234 modified "2023-09-24" @default.
- W2899189234 title "Multi Epitope Peptide Vaccine against Human Parvovirus B19 Using Immuno-Informatics Approaches" @default.
- W2899189234 doi "https://doi.org/10.12691/ajmr-6-4-3" @default.
- W2899189234 hasPublicationYear "2018" @default.
- W2899189234 type Work @default.
- W2899189234 sameAs 2899189234 @default.
- W2899189234 citedByCount "1" @default.
- W2899189234 countsByYear W28991892342022 @default.
- W2899189234 crossrefType "journal-article" @default.
- W2899189234 hasAuthorship W2899189234A5029605964 @default.
- W2899189234 hasAuthorship W2899189234A5047635665 @default.
- W2899189234 hasAuthorship W2899189234A5072603571 @default.
- W2899189234 hasConcept C147483822 @default.
- W2899189234 hasConcept C159047783 @default.
- W2899189234 hasConcept C195616568 @default.
- W2899189234 hasConcept C203014093 @default.
- W2899189234 hasConcept C2522874641 @default.
- W2899189234 hasConcept C2776789287 @default.
- W2899189234 hasConcept C2779630601 @default.
- W2899189234 hasConcept C2780868878 @default.
- W2899189234 hasConcept C2908647359 @default.
- W2899189234 hasConcept C71924100 @default.
- W2899189234 hasConcept C86803240 @default.
- W2899189234 hasConcept C99454951 @default.
- W2899189234 hasConceptScore W2899189234C147483822 @default.
- W2899189234 hasConceptScore W2899189234C159047783 @default.
- W2899189234 hasConceptScore W2899189234C195616568 @default.
- W2899189234 hasConceptScore W2899189234C203014093 @default.
- W2899189234 hasConceptScore W2899189234C2522874641 @default.
- W2899189234 hasConceptScore W2899189234C2776789287 @default.
- W2899189234 hasConceptScore W2899189234C2779630601 @default.
- W2899189234 hasConceptScore W2899189234C2780868878 @default.
- W2899189234 hasConceptScore W2899189234C2908647359 @default.
- W2899189234 hasConceptScore W2899189234C71924100 @default.
- W2899189234 hasConceptScore W2899189234C86803240 @default.
- W2899189234 hasConceptScore W2899189234C99454951 @default.
- W2899189234 hasIssue "4" @default.
- W2899189234 hasLocation W28991892341 @default.
- W2899189234 hasOpenAccess W2899189234 @default.
- W2899189234 hasPrimaryLocation W28991892341 @default.
- W2899189234 hasRelatedWork W2467611713 @default.
- W2899189234 hasRelatedWork W2515664676 @default.
- W2899189234 hasRelatedWork W2515750158 @default.
- W2899189234 hasRelatedWork W2616333630 @default.
- W2899189234 hasRelatedWork W2794304452 @default.
- W2899189234 hasRelatedWork W2801936632 @default.
- W2899189234 hasRelatedWork W2889690902 @default.
- W2899189234 hasRelatedWork W2921641121 @default.
- W2899189234 hasRelatedWork W2924345057 @default.
- W2899189234 hasRelatedWork W2978537494 @default.
- W2899189234 hasRelatedWork W2979846970 @default.
- W2899189234 hasRelatedWork W2982142737 @default.
- W2899189234 hasRelatedWork W3008914528 @default.
- W2899189234 hasRelatedWork W3011391388 @default.
- W2899189234 hasRelatedWork W3011505661 @default.
- W2899189234 hasRelatedWork W3015314967 @default.
- W2899189234 hasRelatedWork W3105235567 @default.
- W2899189234 hasRelatedWork W3121401640 @default.
- W2899189234 hasRelatedWork W3121970976 @default.
- W2899189234 hasRelatedWork W3174809309 @default.
- W2899189234 hasVolume "6" @default.
- W2899189234 isParatext "false" @default.
- W2899189234 isRetracted "false" @default.
- W2899189234 magId "2899189234" @default.
- W2899189234 workType "article" @default.