Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899190122> ?p ?o ?g. }
- W2899190122 endingPage "554" @default.
- W2899190122 startingPage "543" @default.
- W2899190122 abstract "Abstract The central nervous system (CNS) comprises of neurons, which are responsible for impulse transmission, and glial cells, which surround neurons providing protection and nutrition. Glial cells are categorized into astrocytes, oligodendrocytes, microglial cells, and ependymal cells. Tumors forming from glial cells are called gliomas, and they are classified accordingly into astrocytomas, oligodendrogliomas, and ependymomas. Gliomas are characterized by high mortality rates and degree of malignancy, heterogeneity, and resistance to treatment. Among the molecular players implicated in glioma pathogenesis are members of the fibroblast growth factor (FGF) superfamily as well as their receptors (FGFRs). In the present study, we provide a review of the literature on the role of FGFs and FGFRs in glioma pathogenesis. We also demonstrate that FGFs, and particularly FGF1 and FGF2, bear a variety of mutations in gliomas, while FGFRs are also crucially involved. In fact, several studies show that in gliomas, FGFRs bear mutations, mainly in the tyrosine kinase domains. Specifically, it appears that FGFR1-TACC1 and FGFR3-TACC3 fusions are common in these receptors. A better understanding of the mutations and the molecular players involved in glioma formation will benefit the scientific community, leading to the development of more effective and innovative therapeutic approaches." @default.
- W2899190122 created "2018-11-09" @default.
- W2899190122 creator A5063661834 @default.
- W2899190122 creator A5071164036 @default.
- W2899190122 date "2018-10-31" @default.
- W2899190122 modified "2023-10-01" @default.
- W2899190122 title "The role of fibroblast growth factors and their receptors in gliomas: the mutations involved" @default.
- W2899190122 cites W1644276928 @default.
- W2899190122 cites W1916497314 @default.
- W2899190122 cites W1954061878 @default.
- W2899190122 cites W1967946279 @default.
- W2899190122 cites W1972994807 @default.
- W2899190122 cites W1977838764 @default.
- W2899190122 cites W1980217021 @default.
- W2899190122 cites W1983326868 @default.
- W2899190122 cites W1984275052 @default.
- W2899190122 cites W1985186813 @default.
- W2899190122 cites W2005036868 @default.
- W2899190122 cites W2008550171 @default.
- W2899190122 cites W2014061811 @default.
- W2899190122 cites W2021808464 @default.
- W2899190122 cites W2027239974 @default.
- W2899190122 cites W2031611126 @default.
- W2899190122 cites W2033290922 @default.
- W2899190122 cites W2035743945 @default.
- W2899190122 cites W2047955471 @default.
- W2899190122 cites W2048383480 @default.
- W2899190122 cites W2050226347 @default.
- W2899190122 cites W2054195724 @default.
- W2899190122 cites W2070640008 @default.
- W2899190122 cites W2081069777 @default.
- W2899190122 cites W2086405823 @default.
- W2899190122 cites W2093472725 @default.
- W2899190122 cites W2098466520 @default.
- W2899190122 cites W2101808673 @default.
- W2899190122 cites W2110108339 @default.
- W2899190122 cites W2115298717 @default.
- W2899190122 cites W2117692326 @default.
- W2899190122 cites W2122892477 @default.
- W2899190122 cites W2123400942 @default.
- W2899190122 cites W2125115942 @default.
- W2899190122 cites W2132438476 @default.
- W2899190122 cites W2134885863 @default.
- W2899190122 cites W2148468292 @default.
- W2899190122 cites W2152914442 @default.
- W2899190122 cites W2161376894 @default.
- W2899190122 cites W2263522623 @default.
- W2899190122 cites W2263837770 @default.
- W2899190122 cites W2275588483 @default.
- W2899190122 cites W2300922880 @default.
- W2899190122 cites W2461970819 @default.
- W2899190122 cites W2496496144 @default.
- W2899190122 cites W2518206830 @default.
- W2899190122 cites W2518279154 @default.
- W2899190122 cites W2539131576 @default.
- W2899190122 cites W2552066014 @default.
- W2899190122 cites W2554189289 @default.
- W2899190122 cites W2573726465 @default.
- W2899190122 cites W2586662902 @default.
- W2899190122 cites W2588606270 @default.
- W2899190122 cites W2600434382 @default.
- W2899190122 cites W2610333434 @default.
- W2899190122 cites W2610403529 @default.
- W2899190122 cites W2612175024 @default.
- W2899190122 cites W2736166172 @default.
- W2899190122 cites W2745391459 @default.
- W2899190122 cites W2760574659 @default.
- W2899190122 cites W2760729576 @default.
- W2899190122 cites W2766662961 @default.
- W2899190122 cites W2770550238 @default.
- W2899190122 cites W2782136376 @default.
- W2899190122 cites W2784179116 @default.
- W2899190122 cites W2791795801 @default.
- W2899190122 cites W2793742848 @default.
- W2899190122 cites W2799384061 @default.
- W2899190122 cites W2883461604 @default.
- W2899190122 cites W2951541013 @default.
- W2899190122 cites W4250212224 @default.
- W2899190122 cites W2547127934 @default.
- W2899190122 doi "https://doi.org/10.1515/revneuro-2018-0051" @default.
- W2899190122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30379640" @default.
- W2899190122 hasPublicationYear "2018" @default.
- W2899190122 type Work @default.
- W2899190122 sameAs 2899190122 @default.
- W2899190122 citedByCount "6" @default.
- W2899190122 countsByYear W28991901222020 @default.
- W2899190122 countsByYear W28991901222021 @default.
- W2899190122 countsByYear W28991901222022 @default.
- W2899190122 countsByYear W28991901222023 @default.
- W2899190122 crossrefType "journal-article" @default.
- W2899190122 hasAuthorship W2899190122A5063661834 @default.
- W2899190122 hasAuthorship W2899190122A5071164036 @default.
- W2899190122 hasConcept C101544691 @default.
- W2899190122 hasConcept C169760540 @default.
- W2899190122 hasConcept C170493617 @default.
- W2899190122 hasConcept C2778227246 @default.
- W2899190122 hasConcept C49418065 @default.
- W2899190122 hasConcept C502942594 @default.