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• W2899190832 abstract "We study how initial conditions of the Hodgkin-Huxley model affect the dynamics of simulated neurons. We systematically vary the amplitudes of depolarization currents in order to bring neuron dynamics to stable equilibrium. Our results demonstrate that simulated neurons can have spontaneous spiking or a silent state, depending on the initial conditions. We propose the methodology to study the circumstances under which Purkinje cells transit between hyperpolarized quiescent state (down state) and a depolarized spiking state (up state). We show that results derived using the Hodgkin-Huxley methodology should be carefully analyzed before suggesting a direct relevance to neuroprosthetic implants." @default.
• W2899190832 created "2018-11-09" @default.
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• W2899190832 date "2018-07-01" @default.
• W2899190832 modified "2023-10-16" @default.
• W2899190832 title "Bistability in Hodgkin-Huxley-type equations" @default.
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• W2899190832 doi "https://doi.org/10.1109/embc.2018.8513233" @default.
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• W2899190832 hasPublicationYear "2018" @default.
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