Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899193772> ?p ?o ?g. }
- W2899193772 abstract "Norepinephrine (NE) signaling has a key role in white adipose tissue (WAT) functions, including lipolysis, free fatty acid liberation and, under certain conditions, conversion of white into brite (brown-in-white) adipocytes. However, acute effects of NE stimulation have not been described at the transcriptional network level. We used RNA-seq to uncover a broad transcriptional response. The inference of protein-protein and protein-DNA interaction networks allowed us to identify a set of immediate-early genes (IEGs) with high betweenness, validating our approach and suggesting a hierarchical control of transcriptional regulation. In addition, we identified a transcriptional regulatory network with IEGs as master regulators, including HSF1 and NFIL3 as novel NE-induced IEG candidates. Moreover, a functional enrichment analysis and gene clustering into functional modules suggest a crosstalk between metabolic, signaling, and immune responses. Altogether, our network biology approach explores for the first time the immediate-early systems level response of human adipocytes to acute sympathetic activation, thereby providing a first network basis of early cell fate programs and crosstalks between metabolic and transcriptional networks required for proper WAT function." @default.
- W2899193772 created "2018-11-09" @default.
- W2899193772 creator A5002808509 @default.
- W2899193772 creator A5034258386 @default.
- W2899193772 creator A5048756693 @default.
- W2899193772 creator A5059342168 @default.
- W2899193772 creator A5073008608 @default.
- W2899193772 creator A5078915802 @default.
- W2899193772 creator A5087546848 @default.
- W2899193772 date "2018-11-03" @default.
- W2899193772 modified "2023-10-18" @default.
- W2899193772 title "Norepinephrine triggers an immediate-early regulatory network response in primary human white adipocytes" @default.
- W2899193772 cites W1078890791 @default.
- W2899193772 cites W1527449024 @default.
- W2899193772 cites W1561757844 @default.
- W2899193772 cites W1562427827 @default.
- W2899193772 cites W1573089314 @default.
- W2899193772 cites W1677560495 @default.
- W2899193772 cites W1718233288 @default.
- W2899193772 cites W1810629227 @default.
- W2899193772 cites W1834426811 @default.
- W2899193772 cites W1921041368 @default.
- W2899193772 cites W1923854859 @default.
- W2899193772 cites W1973042766 @default.
- W2899193772 cites W1979026577 @default.
- W2899193772 cites W1981018568 @default.
- W2899193772 cites W1981243279 @default.
- W2899193772 cites W1985569332 @default.
- W2899193772 cites W1992062845 @default.
- W2899193772 cites W1993702356 @default.
- W2899193772 cites W2007222211 @default.
- W2899193772 cites W2010104326 @default.
- W2899193772 cites W2012347983 @default.
- W2899193772 cites W2023650135 @default.
- W2899193772 cites W2023960671 @default.
- W2899193772 cites W2027753197 @default.
- W2899193772 cites W2030036012 @default.
- W2899193772 cites W2031600325 @default.
- W2899193772 cites W2039236418 @default.
- W2899193772 cites W2039751039 @default.
- W2899193772 cites W2042461504 @default.
- W2899193772 cites W2046642142 @default.
- W2899193772 cites W2053809576 @default.
- W2899193772 cites W2060474003 @default.
- W2899193772 cites W2060501224 @default.
- W2899193772 cites W2075561913 @default.
- W2899193772 cites W2080942463 @default.
- W2899193772 cites W2083602312 @default.
- W2899193772 cites W2088089995 @default.
- W2899193772 cites W2092320751 @default.
- W2899193772 cites W2095403534 @default.
- W2899193772 cites W2095495840 @default.
- W2899193772 cites W2097203581 @default.
- W2899193772 cites W2098457930 @default.
- W2899193772 cites W2099988909 @default.
- W2899193772 cites W2100755177 @default.
- W2899193772 cites W2101494964 @default.
- W2899193772 cites W2103912979 @default.
- W2899193772 cites W2107038109 @default.
- W2899193772 cites W2107281049 @default.
- W2899193772 cites W2107359522 @default.
- W2899193772 cites W2107863336 @default.
- W2899193772 cites W2108517818 @default.
- W2899193772 cites W2109840033 @default.
- W2899193772 cites W2110645284 @default.
- W2899193772 cites W2111336104 @default.
- W2899193772 cites W2111823238 @default.
- W2899193772 cites W2112016110 @default.
- W2899193772 cites W2114821999 @default.
- W2899193772 cites W2116023900 @default.
- W2899193772 cites W2116424563 @default.
- W2899193772 cites W2119114096 @default.
- W2899193772 cites W2124132231 @default.
- W2899193772 cites W2127410541 @default.
- W2899193772 cites W2132358997 @default.
- W2899193772 cites W2132695367 @default.
- W2899193772 cites W2132870280 @default.
- W2899193772 cites W2136170412 @default.
- W2899193772 cites W2138207763 @default.
- W2899193772 cites W2138973294 @default.
- W2899193772 cites W2144409619 @default.
- W2899193772 cites W2149119575 @default.
- W2899193772 cites W2150318080 @default.
- W2899193772 cites W2152135248 @default.
- W2899193772 cites W2156673166 @default.
- W2899193772 cites W2159675211 @default.
- W2899193772 cites W2163480486 @default.
- W2899193772 cites W2172338503 @default.
- W2899193772 cites W2172557341 @default.
- W2899193772 cites W2175705580 @default.
- W2899193772 cites W2179438025 @default.
- W2899193772 cites W2190430248 @default.
- W2899193772 cites W2273877888 @default.
- W2899193772 cites W2287163002 @default.
- W2899193772 cites W2291246210 @default.
- W2899193772 cites W2297104511 @default.
- W2899193772 cites W2302666737 @default.
- W2899193772 cites W2329247039 @default.
- W2899193772 cites W2349918789 @default.
- W2899193772 cites W2518168071 @default.