Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899197889> ?p ?o ?g. }
- W2899197889 endingPage "C153" @default.
- W2899197889 startingPage "C135" @default.
- W2899197889 abstract "As part of the neurovascular unit, the blood-brain barrier (BBB) is a unique, dynamic regulatory boundary that limits and regulates the exchange of molecules, ions, and cells between the blood and the central nervous system. Disruption of the BBB plays an important role in the development of neurological dysfunction in ischemic stroke. Blood-borne substances and cells have restricted access to the brain due to the presence of tight junctions between the endothelial cells of the BBB. Following stroke, there is loss of BBB tight junction integrity, leading to increased paracellular permeability, which results in vasogenic edema, hemorrhagic transformation, and increased mortality. Thus, understanding principal mediators and molecular mechanisms involved in BBB disruption is critical for the development of novel therapeutics to treat ischemic stroke. This review discusses the current knowledge of how neuroinflammation contributes to BBB damage in ischemic stroke. Specifically, we provide an updated overview of the role of cytokines, chemokines, oxidative and nitrosative stress, adhesion molecules, matrix metalloproteinases, and vascular endothelial growth factor as well as the role of different cell types in the regulation of BBB permeability in ischemic stroke." @default.
- W2899197889 created "2018-11-09" @default.
- W2899197889 creator A5001458728 @default.
- W2899197889 creator A5037978001 @default.
- W2899197889 creator A5049745844 @default.
- W2899197889 creator A5064044893 @default.
- W2899197889 date "2019-02-01" @default.
- W2899197889 modified "2023-10-16" @default.
- W2899197889 title "Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke" @default.
- W2899197889 cites W109974507 @default.
- W2899197889 cites W1482195692 @default.
- W2899197889 cites W1505588706 @default.
- W2899197889 cites W1513845930 @default.
- W2899197889 cites W1514513302 @default.
- W2899197889 cites W1523932090 @default.
- W2899197889 cites W1544105159 @default.
- W2899197889 cites W1582972890 @default.
- W2899197889 cites W1594425991 @default.
- W2899197889 cites W1619234695 @default.
- W2899197889 cites W1667686291 @default.
- W2899197889 cites W1697537733 @default.
- W2899197889 cites W1773656017 @default.
- W2899197889 cites W1778136690 @default.
- W2899197889 cites W1826355858 @default.
- W2899197889 cites W1843199965 @default.
- W2899197889 cites W1946941723 @default.
- W2899197889 cites W1955736456 @default.
- W2899197889 cites W1957113176 @default.
- W2899197889 cites W1963766511 @default.
- W2899197889 cites W1963873817 @default.
- W2899197889 cites W1965658881 @default.
- W2899197889 cites W1966841015 @default.
- W2899197889 cites W1967081185 @default.
- W2899197889 cites W1968057097 @default.
- W2899197889 cites W1968199365 @default.
- W2899197889 cites W1968940085 @default.
- W2899197889 cites W1969182835 @default.
- W2899197889 cites W1970341486 @default.
- W2899197889 cites W1971213778 @default.
- W2899197889 cites W1971556924 @default.
- W2899197889 cites W1972408244 @default.
- W2899197889 cites W1972696524 @default.
- W2899197889 cites W1973338533 @default.
- W2899197889 cites W1973393911 @default.
- W2899197889 cites W1975361661 @default.
- W2899197889 cites W1975400014 @default.
- W2899197889 cites W1975941571 @default.
- W2899197889 cites W1978356252 @default.
- W2899197889 cites W1979390430 @default.
- W2899197889 cites W1979812793 @default.
- W2899197889 cites W1980276519 @default.
- W2899197889 cites W1981425827 @default.
- W2899197889 cites W1981921279 @default.
- W2899197889 cites W1982542349 @default.
- W2899197889 cites W1985221375 @default.
- W2899197889 cites W1985402737 @default.
- W2899197889 cites W1985455477 @default.
- W2899197889 cites W1987177757 @default.
- W2899197889 cites W1987197699 @default.
- W2899197889 cites W1988333213 @default.
- W2899197889 cites W1988551550 @default.
- W2899197889 cites W1989060870 @default.
- W2899197889 cites W1989737822 @default.
- W2899197889 cites W1990136719 @default.
- W2899197889 cites W1990985572 @default.
- W2899197889 cites W1991063980 @default.
- W2899197889 cites W1991156617 @default.
- W2899197889 cites W1991705223 @default.
- W2899197889 cites W1992633183 @default.
- W2899197889 cites W1992981081 @default.
- W2899197889 cites W1994159589 @default.
- W2899197889 cites W1995446848 @default.
- W2899197889 cites W1996024251 @default.
- W2899197889 cites W1996347218 @default.
- W2899197889 cites W1997595168 @default.
- W2899197889 cites W1997776983 @default.
- W2899197889 cites W1997871462 @default.
- W2899197889 cites W1997878733 @default.
- W2899197889 cites W1999288895 @default.
- W2899197889 cites W2000351290 @default.
- W2899197889 cites W2001552996 @default.
- W2899197889 cites W2004159587 @default.
- W2899197889 cites W2004239325 @default.
- W2899197889 cites W2005675003 @default.
- W2899197889 cites W2006632378 @default.
- W2899197889 cites W2008809619 @default.
- W2899197889 cites W2010461736 @default.
- W2899197889 cites W2010462844 @default.
- W2899197889 cites W2011349107 @default.
- W2899197889 cites W2012610329 @default.
- W2899197889 cites W2014848130 @default.
- W2899197889 cites W2015085032 @default.
- W2899197889 cites W2015541518 @default.
- W2899197889 cites W2015615473 @default.
- W2899197889 cites W2015831317 @default.
- W2899197889 cites W2016575029 @default.
- W2899197889 cites W2017172546 @default.
- W2899197889 cites W2017174153 @default.