FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899199192> ?p ?o ?g. }

• W2899199192 endingPage "e2018067" @default.
• W2899199192 startingPage "e2018067" @default.
• W2899199192 abstract "Systemic autoinflammatory disorders (SAIDs) are inherited defects of innate immunity characterized by recurrent sterile inflammatory attacks involving skin, joints, serosal membranes, gastrointestinal tube and other tissues, which recur with variable rhythmicity and display reactive amyloidosis as a potential long-term complication. Dysregulated inflammasome activity leading to overproduction of many proinflammatory cytokines, such as interleukin-1 (IL-1), and delayed shutdown of inflammation are considered crucial pathogenic keys in the vast majority of SAIDs. Progresses of cellular biology have partially clarified the mechanisms behind monogenic SAIDs, such as familial Mediterranean fever, tumor necrosis factor receptor-associated periodic syndrome, cryopyrin-associated periodic syndrome, mevalonate kinase deficiency, hereditary pyogenic diseases, idiopathic granulomatous diseases and defects of the ubiquitin-proteasome pathway, whereas little is clarified for the polygenic SAIDs, such as periodic fever, aphthous stomatitis, pharyngitis and cervical adenopathy (PFAPA) syndrome. The puzzle of symptomatic febrile attacks recurring over time in children requires evaluating the mixture of clinical data, inflammatory parameters in different disease phases, therapeutic efficacy of specific drugs such as colchicine, corticosteroids or IL-1 antagonists, and genotype analysis in selected cases. Long-term history of periodic fevers should also need to rule out chronic infections and malignancies. This review is conceived as a practical template for a proper classification of children with recurring fevers and includes tips useful for the diagnostic approach to SAIDs, focusing on the specific acute painful symptoms and blood manifestations encountered in childhood." @default.
• W2899199192 created "2018-11-09" @default.
• W2899199192 creator A5058658304 @default.
• W2899199192 date "2018-10-30" @default.
• W2899199192 modified "2023-09-30" @default.
• W2899199192 title "THE BROAD-RANGING PANORAMA OF SYSTEMIC AUTOINFLAMMATORY DISORDERS WITH SPECIFIC FOCUS ON ACUTE PAINFUL SYMPTOMS AND HEMATOLOGIC MANIFESTATIONS IN CHILDREN" @default.
• W2899199192 cites W101803744 @default.
• W2899199192 cites W120733472 @default.
• W2899199192 cites W165920092 @default.
• W2899199192 cites W1769657025 @default.
• W2899199192 cites W179204766 @default.
• W2899199192 cites W1795749572 @default.
• W2899199192 cites W1932681486 @default.
• W2899199192 cites W1964034086 @default.
• W2899199192 cites W1966359368 @default.
• W2899199192 cites W1968540198 @default.
• W2899199192 cites W1977164682 @default.
• W2899199192 cites W1977554771 @default.
• W2899199192 cites W1980442164 @default.
• W2899199192 cites W1980705501 @default.
• W2899199192 cites W1981021218 @default.
• W2899199192 cites W1984037289 @default.
• W2899199192 cites W1984821014 @default.
• W2899199192 cites W1985383819 @default.
• W2899199192 cites W1986292712 @default.
• W2899199192 cites W1989504008 @default.
• W2899199192 cites W1992058869 @default.
• W2899199192 cites W1995197668 @default.
• W2899199192 cites W1996460626 @default.
• W2899199192 cites W2007315205 @default.
• W2899199192 cites W2008033277 @default.
• W2899199192 cites W2010920001 @default.
• W2899199192 cites W2017851980 @default.
• W2899199192 cites W2024396521 @default.
• W2899199192 cites W2025137288 @default.
• W2899199192 cites W2027596014 @default.
• W2899199192 cites W2028733973 @default.
• W2899199192 cites W2030929506 @default.
• W2899199192 cites W2035871745 @default.
• W2899199192 cites W2044925316 @default.
• W2899199192 cites W2061264362 @default.
• W2899199192 cites W2063675796 @default.
• W2899199192 cites W206403293 @default.
• W2899199192 cites W2064915342 @default.
• W2899199192 cites W2071556127 @default.
• W2899199192 cites W2073492215 @default.
• W2899199192 cites W2078640226 @default.
• W2899199192 cites W2083278536 @default.
• W2899199192 cites W2086147112 @default.
• W2899199192 cites W2086559156 @default.
• W2899199192 cites W2088254488 @default.
• W2899199192 cites W2090008242 @default.
• W2899199192 cites W2092264647 @default.
• W2899199192 cites W2096156278 @default.
• W2899199192 cites W2101548148 @default.
• W2899199192 cites W2102151747 @default.
• W2899199192 cites W2108581377 @default.
• W2899199192 cites W2112585290 @default.
• W2899199192 cites W2121837801 @default.
• W2899199192 cites W2127005697 @default.
• W2899199192 cites W2140276493 @default.
• W2899199192 cites W2140398687 @default.
• W2899199192 cites W2147116928 @default.
• W2899199192 cites W2152624985 @default.
• W2899199192 cites W2159386336 @default.
• W2899199192 cites W2162089651 @default.
• W2899199192 cites W2167120554 @default.
• W2899199192 cites W2169001554 @default.
• W2899199192 cites W2170936782 @default.
• W2899199192 cites W2182694720 @default.
• W2899199192 cites W2253325073 @default.
• W2899199192 cites W2284005203 @default.
• W2899199192 cites W2319906249 @default.
• W2899199192 cites W2326861977 @default.
• W2899199192 cites W2331395777 @default.
• W2899199192 cites W2405226129 @default.
• W2899199192 cites W2407551672 @default.
• W2899199192 cites W2416106144 @default.
• W2899199192 cites W2418840180 @default.
• W2899199192 cites W2510683315 @default.
• W2899199192 cites W2510750944 @default.
• W2899199192 cites W2527759663 @default.
• W2899199192 cites W2534735969 @default.
• W2899199192 cites W2548885112 @default.
• W2899199192 cites W2569807093 @default.
• W2899199192 cites W2591843498 @default.
• W2899199192 cites W2593754097 @default.
• W2899199192 cites W2601204912 @default.
• W2899199192 cites W2612174350 @default.
• W2899199192 cites W2622121047 @default.
• W2899199192 cites W2735482357 @default.
• W2899199192 cites W2742590969 @default.
• W2899199192 cites W2743361461 @default.
• W2899199192 cites W2747670675 @default.
• W2899199192 cites W2748385947 @default.
• W2899199192 cites W2767454393 @default.
• W2899199192 cites W2771848945 @default.
• W2899199192 cites W2778714551 @default.

• next