Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899199699> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2899199699 abstract "Backgrond: Functional gastrointestinal disorders (FGID) are chronic conditions characterized by symptoms for which no overt organic cause can be found. They affect up to 20% of western populations with evidence suggesting they are equally common in the Third World (Spiller 2005). Although symptoms are generally mild or moderate, a small subset of cases shows severe manifestations, i.e. nausea, vomiting, bloating, abdominal distension, intractable constipation and chronic pain, with such an intensity hampering normal feeding and compromising considerably patients’ quality of life. In addition, this subset of patients may also have recurrent intestinal sub-occlusive episodes, which occur in the absence of demonstrable mechanical causes, leading to numerous hospitalizations as well as useless and potentially harmful surgical interventions. This condition is referred to as chronic intestinal pseudo-obstruction (CIPO), a rare and intractable chronic digestive disease with symptoms and signs of intestinal obstruction without demonstrable mechanical cause. CIPO can result from derangements affecting the integrity of a variety of regulatory cells/tissues, i.e. smooth muscle cells, the interstitial cells of Cajal (ICC) (pace-makers of gut motility), and neurons (either intrinsic – the enteric nervous system- or extrinsic nerve pathways). Aims and experimental studies: The present thesis was conceived to provide a thorough account of the molecular defects underlying CIPO and highlight new strategies of neuro-epithelial protection to prevent enteric neurodegeneration. The experimental studies are based on genetic analysis of CIPO patients and characterization of RAD21 in the ENS of human and mouse intestine. Other studies are focus on 5-hydroxytryptamine-4 (5-HT4) receptor particularly studying whether the activation of colonic epithelial 5-HT4 protects against experimentally induced inflammation of the mouse colon.Conclusion: My thesis focuses on both mechanisms of neurodegeneration and neuro/epithelial protection as a paradigm to better understand both pathophysiology of severe conditions such as CIPO, and related targeted therapeutic options." @default.
- W2899199699 created "2018-11-09" @default.
- W2899199699 creator A5088831574 @default.
- W2899199699 date "2018-05-09" @default.
- W2899199699 modified "2023-09-23" @default.
- W2899199699 title "New Insights into Molecular Mechanisms of Enteric Neuro-Epithelial Pathology: From Damage to Protection" @default.
- W2899199699 doi "https://doi.org/10.6092/unibo/amsdottorato/8376" @default.
- W2899199699 hasPublicationYear "2018" @default.
- W2899199699 type Work @default.
- W2899199699 sameAs 2899199699 @default.
- W2899199699 citedByCount "0" @default.
- W2899199699 crossrefType "dissertation" @default.
- W2899199699 hasAuthorship W2899199699A5088831574 @default.
- W2899199699 hasConcept C126322002 @default.
- W2899199699 hasConcept C142724271 @default.
- W2899199699 hasConcept C201539569 @default.
- W2899199699 hasConcept C204232928 @default.
- W2899199699 hasConcept C2776956441 @default.
- W2899199699 hasConcept C2777439022 @default.
- W2899199699 hasConcept C2778769438 @default.
- W2899199699 hasConcept C2779134260 @default.
- W2899199699 hasConcept C2779422922 @default.
- W2899199699 hasConcept C2780852908 @default.
- W2899199699 hasConcept C2780955771 @default.
- W2899199699 hasConcept C2781112942 @default.
- W2899199699 hasConcept C3020479747 @default.
- W2899199699 hasConcept C60644358 @default.
- W2899199699 hasConcept C71924100 @default.
- W2899199699 hasConcept C86803240 @default.
- W2899199699 hasConcept C90924648 @default.
- W2899199699 hasConceptScore W2899199699C126322002 @default.
- W2899199699 hasConceptScore W2899199699C142724271 @default.
- W2899199699 hasConceptScore W2899199699C201539569 @default.
- W2899199699 hasConceptScore W2899199699C204232928 @default.
- W2899199699 hasConceptScore W2899199699C2776956441 @default.
- W2899199699 hasConceptScore W2899199699C2777439022 @default.
- W2899199699 hasConceptScore W2899199699C2778769438 @default.
- W2899199699 hasConceptScore W2899199699C2779134260 @default.
- W2899199699 hasConceptScore W2899199699C2779422922 @default.
- W2899199699 hasConceptScore W2899199699C2780852908 @default.
- W2899199699 hasConceptScore W2899199699C2780955771 @default.
- W2899199699 hasConceptScore W2899199699C2781112942 @default.
- W2899199699 hasConceptScore W2899199699C3020479747 @default.
- W2899199699 hasConceptScore W2899199699C60644358 @default.
- W2899199699 hasConceptScore W2899199699C71924100 @default.
- W2899199699 hasConceptScore W2899199699C86803240 @default.
- W2899199699 hasConceptScore W2899199699C90924648 @default.
- W2899199699 hasLocation W28991996991 @default.
- W2899199699 hasOpenAccess W2899199699 @default.
- W2899199699 hasPrimaryLocation W28991996991 @default.
- W2899199699 hasRelatedWork W1513588731 @default.
- W2899199699 hasRelatedWork W1661860966 @default.
- W2899199699 hasRelatedWork W1805824803 @default.
- W2899199699 hasRelatedWork W1931200414 @default.
- W2899199699 hasRelatedWork W1990723419 @default.
- W2899199699 hasRelatedWork W2010664054 @default.
- W2899199699 hasRelatedWork W2010843219 @default.
- W2899199699 hasRelatedWork W2042143933 @default.
- W2899199699 hasRelatedWork W2066311579 @default.
- W2899199699 hasRelatedWork W2118669156 @default.
- W2899199699 hasRelatedWork W2166024334 @default.
- W2899199699 hasRelatedWork W2336162664 @default.
- W2899199699 hasRelatedWork W2359436398 @default.
- W2899199699 hasRelatedWork W2396979806 @default.
- W2899199699 hasRelatedWork W2405565625 @default.
- W2899199699 hasRelatedWork W2513213841 @default.
- W2899199699 hasRelatedWork W2862060056 @default.
- W2899199699 hasRelatedWork W2891236476 @default.
- W2899199699 hasRelatedWork W91315217 @default.
- W2899199699 hasRelatedWork W2358102057 @default.
- W2899199699 isParatext "false" @default.
- W2899199699 isRetracted "false" @default.
- W2899199699 magId "2899199699" @default.
- W2899199699 workType "dissertation" @default.