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- W2899207699 abstract "Abstract To investigate the function of the duck enteritis virus (DEV) tegument protein US10, we generated US10 deletion and revertant mutants (ΔUS10 and US10FRT) via two-step RED recombination based on an infectious BAC clone of DEV CHv-BAC-G (BAC-G). In multistep growth kinetic analyses, ΔUS10 showed an approximately 100-fold reduction in viral titer, while the genome copies decreased only 4-fold compared to those of BAC-G. In one-step growth kinetic analyses, there were no significant differences in genome copies among BAC-G, ΔUS10 and US10FRT, but ΔUS10 still showed a 5- to 20-fold reduction in viral titer, and the replication defect of ΔUS10 was partially reversed by infection of US10-expressing cells. The transcription levels of Mx, OASL, IL-4, IL-6 and IL-10 in ΔUS10-infected duck embryo fibroblasts (DEFs) were significantly upregulated, while TLR3 was downregulated compared with those in BAC-G-infected DEFs. Taken together, these data indicated that US10 is vital for DEV replication and is associated with transcription of some immunity genes." @default.
- W2899207699 created "2018-11-09" @default.
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- W2899207699 date "2018-11-07" @default.
- W2899207699 modified "2023-10-14" @default.
- W2899207699 title "US10 Protein Is Crucial but not Indispensable for Duck Enteritis Virus Infection in Vitro" @default.
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- W2899207699 doi "https://doi.org/10.1038/s41598-018-34503-7" @default.
- W2899207699 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6220328" @default.
- W2899207699 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30405139" @default.
- W2899207699 hasPublicationYear "2018" @default.
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