Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899211111> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2899211111 endingPage "5" @default.
- W2899211111 startingPage "5" @default.
- W2899211111 abstract "Objective: The present research work aims at describing the formulation and evaluation of the ocular delivery system of moxifloxacin hydrochloride (MH) based on the concept of ion sensitive in situ gelations.Methods: In situ gel was prepared by a hot method using 0.6% of gelrite, 0.25% hydroxypropylmethylcellulose (HPMC K4M) and 0.023% tamarind gum as bioadhesive polymers for sustained drug release. Optimization was done by Box Behnken Design with different concentration of gelrite (X1), HPMC K4M (X2) and tamarind gum (X3) as independent variables. In situ gel was optimized based on mucoadhesion index (Y1), Gel strength (Y2) and in vitro drug release (Y3). Influence of the quantitative variable on the dependent variable was predicted by a polynomial equation.Results: Infrared spectroscopy excluded any interaction between drug and excipients. The selected independent variables significantly influenced the responses and were able to sustain the drug release. The prepared gel with a pH of 6.8 to 7.4 exhibited non-newtonian flow with no ocular irritation. The formulation remained stable with no change in pH and viscosity after 30 d of stability study.Conclusion: Thus, moxifloxacin hydrochloride (MH) in situ gel is a viable alternative to a conventional delivery system with the properties of sustained drug release, prolonged ocular retention, and improved corneal penetration." @default.
- W2899211111 created "2018-11-09" @default.
- W2899211111 creator A5001571521 @default.
- W2899211111 creator A5034660650 @default.
- W2899211111 creator A5036011872 @default.
- W2899211111 creator A5046215706 @default.
- W2899211111 creator A5072951064 @default.
- W2899211111 creator A5090086560 @default.
- W2899211111 date "2018-12-01" @default.
- W2899211111 modified "2023-10-16" @default.
- W2899211111 title "NEWER OPHTHALMIC IN SITU GEL OF MOXIFLOXACIN HYDROCHLORIDE: OPTIMIZATION USING BOX BEHNKEN STATISTICAL DESIGN" @default.
- W2899211111 cites W1963734752 @default.
- W2899211111 cites W1967267374 @default.
- W2899211111 cites W1981687383 @default.
- W2899211111 cites W1987457008 @default.
- W2899211111 cites W1993647000 @default.
- W2899211111 cites W2012245891 @default.
- W2899211111 cites W2086606866 @default.
- W2899211111 cites W2088187401 @default.
- W2899211111 cites W2093372703 @default.
- W2899211111 cites W2102530041 @default.
- W2899211111 cites W2134307459 @default.
- W2899211111 cites W2152411700 @default.
- W2899211111 cites W2253625110 @default.
- W2899211111 cites W2501273893 @default.
- W2899211111 cites W2590921512 @default.
- W2899211111 cites W2614357744 @default.
- W2899211111 cites W2767864205 @default.
- W2899211111 cites W2800210354 @default.
- W2899211111 cites W2816834148 @default.
- W2899211111 cites W2188317043 @default.
- W2899211111 doi "https://doi.org/10.22159/ijpps.2018v10i12.26979" @default.
- W2899211111 hasPublicationYear "2018" @default.
- W2899211111 type Work @default.
- W2899211111 sameAs 2899211111 @default.
- W2899211111 citedByCount "2" @default.
- W2899211111 countsByYear W28992111112019 @default.
- W2899211111 countsByYear W28992111112023 @default.
- W2899211111 crossrefType "journal-article" @default.
- W2899211111 hasAuthorship W2899211111A5001571521 @default.
- W2899211111 hasAuthorship W2899211111A5034660650 @default.
- W2899211111 hasAuthorship W2899211111A5036011872 @default.
- W2899211111 hasAuthorship W2899211111A5046215706 @default.
- W2899211111 hasAuthorship W2899211111A5072951064 @default.
- W2899211111 hasAuthorship W2899211111A5090086560 @default.
- W2899211111 hasBestOaLocation W28992111111 @default.
- W2899211111 hasConcept C136229726 @default.
- W2899211111 hasConcept C150077022 @default.
- W2899211111 hasConcept C170295934 @default.
- W2899211111 hasConcept C178790620 @default.
- W2899211111 hasConcept C185592680 @default.
- W2899211111 hasConcept C192562407 @default.
- W2899211111 hasConcept C2776634624 @default.
- W2899211111 hasConcept C2777822432 @default.
- W2899211111 hasConcept C2779820397 @default.
- W2899211111 hasConcept C2780020223 @default.
- W2899211111 hasConcept C43617362 @default.
- W2899211111 hasConcept C71924100 @default.
- W2899211111 hasConceptScore W2899211111C136229726 @default.
- W2899211111 hasConceptScore W2899211111C150077022 @default.
- W2899211111 hasConceptScore W2899211111C170295934 @default.
- W2899211111 hasConceptScore W2899211111C178790620 @default.
- W2899211111 hasConceptScore W2899211111C185592680 @default.
- W2899211111 hasConceptScore W2899211111C192562407 @default.
- W2899211111 hasConceptScore W2899211111C2776634624 @default.
- W2899211111 hasConceptScore W2899211111C2777822432 @default.
- W2899211111 hasConceptScore W2899211111C2779820397 @default.
- W2899211111 hasConceptScore W2899211111C2780020223 @default.
- W2899211111 hasConceptScore W2899211111C43617362 @default.
- W2899211111 hasConceptScore W2899211111C71924100 @default.
- W2899211111 hasIssue "12" @default.
- W2899211111 hasLocation W28992111111 @default.
- W2899211111 hasOpenAccess W2899211111 @default.
- W2899211111 hasPrimaryLocation W28992111111 @default.
- W2899211111 hasRelatedWork W2098879162 @default.
- W2899211111 hasRelatedWork W2101059745 @default.
- W2899211111 hasRelatedWork W2130026714 @default.
- W2899211111 hasRelatedWork W2248335811 @default.
- W2899211111 hasRelatedWork W2337589616 @default.
- W2899211111 hasRelatedWork W2365528462 @default.
- W2899211111 hasRelatedWork W2497738621 @default.
- W2899211111 hasRelatedWork W2556712958 @default.
- W2899211111 hasRelatedWork W2996866042 @default.
- W2899211111 hasRelatedWork W3217388380 @default.
- W2899211111 hasVolume "10" @default.
- W2899211111 isParatext "false" @default.
- W2899211111 isRetracted "false" @default.
- W2899211111 magId "2899211111" @default.
- W2899211111 workType "article" @default.