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- W2899214253 abstract "Cancer stem cells (CSCs) are potential platforms to high-throughput screen anti-cancer drugs. However, they are difficult to isolate from cancer cells. Therefore, we proposed to fabricate 3-D scaffolds for CSC enrichment. Alginate is a biocompatible polysaccharide with poor cell adhesion, whereas polycaprolactone (PCL) is relative cell adhesive. These two materials were coelectrospun as composite scaffolds. Cells collected from alginate and composite fibers demonstrated high stemness, epithelial-mesenchymal transition, invasion, drug resistance, and angiogenesis. Interestingly, cells collected from composite fibers with low ratio of PCL were significantly improved their CSC properties compared to those from pure alginate fibers because few PCL fibers spatially separated cell populations to concentrate CSCs. These results suggested that alginate fibers effectively enriched CSCs and composite fibers created an uneven microenvironment to regulate cell morphology and distribution, by which cell-cell interaction was thus manipulated. These tunable scaffolds are potential to isolate CSCs from different tissues to facilitate the cancer research." @default.
- W2899214253 created "2018-11-09" @default.
- W2899214253 creator A5030117116 @default.
- W2899214253 creator A5042961174 @default.
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- W2899214253 date "2019-02-01" @default.
- W2899214253 modified "2023-10-02" @default.
- W2899214253 title "The enrichment of cancer stem cells using composite alginate/polycaprolactone nanofibers" @default.
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- W2899214253 doi "https://doi.org/10.1016/j.carbpol.2018.10.087" @default.
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