Matches in SemOpenAlex for { <https://semopenalex.org/work/W2899215518> ?p ?o ?g. }
- W2899215518 abstract "T cells form adhesive contacts with antigen-presenting cells (APCs) as part of the normal surveillance process that occurs in lymph nodes and other tissues. Most of these adhesive interactions are formed by integrins that interact with ligands expressed on the surface of the APC. The interactive strength of integrins depends on their degree of membrane proximity as well as intracellular signals that dictate the conformation of the integrin. Integrins appear in different conformations that endow them with different affinities for their ligand(s). Integrin conformation and thus adhesive strength between the T cell and the APC is tuned by intracellular signals that are turned on by ligation of the T cell receptor and chemokine receptors. During the different stages of the process, integrins, the TCR and chemokine receptors may be interconnected by the actin cytoskeleton underneath the plasma membrane, forming a chemical and physical network that facilitates the spatiotemporal dynamics, positioning and function of these receptors and supports cell-cell adhesion during T cell activation, allowing it to perform its effector function." @default.
- W2899215518 created "2018-11-09" @default.
- W2899215518 creator A5042124020 @default.
- W2899215518 creator A5072788498 @default.
- W2899215518 creator A5074603864 @default.
- W2899215518 date "2018-10-30" @default.
- W2899215518 modified "2023-10-14" @default.
- W2899215518 title "Adhesive Interactions Delineate the Topography of the Immune Synapse" @default.
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